Paulo José Garcia de Lemos Trigueiros de Martel
Professor auxiliar
Faculdade de Ciências e Tecnologia
Subsistema
Docentes Universitário
Unidade ID externa
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Paulo José Martel. Completed the Doutoramento in Protein Electrostatics: Theory, Methods and Applications in 2006/06/01 by Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica and Licenciatura in Bioquímica in 1988 by Universidade de Lisboa Faculdade de Ciências. Is Assistant Professor in Universidade do Algarve - Campus de Gambelas. Published 24 articles in journals. Has 4 section(s) of books and 2 book(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Biophysics and Exact Sciences with emphasis on Computer and Information Sciences with emphasis on Bioinformatics. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Bioinformatics; Machine Learning ; Computational Biology ; Molecular Modelling; Computer-Aided Drug Design; Protein molecular modelling; Biomolecular Modelling; Protein Electrostatics; Molecular Dynamics; Structural Bioinformatics; Structural Modelling; Computational Drug Design; .
Atividades
Atividades
2018 - Presente. Outro júri / avaliação. Member of evaluation panel for Agência Nacional de Informação (ANI) research grants.. Agência Nacional de Inovação SA.
2010 - 2015. Orientação. Optimization of Molecular Dynamics Simulation Code and Applications to Biomolecular Systems.Computational Biochemisry (Doutoramento). Orientador de David Malcolm Bowman.
2004 - 2014. Membro de comissão. As Scientific Coordinator of CBMR, I was in charge of scientific and administrative coordination and steering of CBME activities. CBMR was research center in University of the Algarve ranked as "very good" by the Portuguese Science Foundation, with around 30 PIs at its peak and activities covering a range of subjects in Biomedical Research including Cancer, Regeneration, Developmental Biology, Biotech, Microbiology, Cognitive Sciences, Molecular Toxicology, Nanotech, Computational Biology, Bioinformatics and Molecular Modelling. . Coordenador. Universidade do Algarve Centro de Investigação em Biomedicina.
2013 - Presente. Membro de comissão. Member of the Scientific Committee for Neurosciences Scientific Prizes of Santa Casa da Misericórdia de Lisboa. Duties including evaluatio of grant progress reports and counselling an all issues related with prize regulations and management of applications. . Consultor. Santa Casa da Misericórdia de Lisboa.
Projetos
Projetos
2012/02 - 2015/10. Alternative splicing and its impact on molecular networks during stem cell differentiation.
2012/02 - 2015/04. A Biophysical Approach to Oxidative Protein Folding in the ER: Relative Importance of Ero1 and Prdx4 alternative pathways.
2009/01 - 2012/12. Thermodynamic Signature of the Pregnane Xenobiotic Receptor Activation by Quartz Crystal Microbalance with Heat Conduction Calorimetry.
2009/01 - 2012/06. Biomolecular Engineering Approches for in vitro Production of Self Assembly Viral Nanoparticles.
2005/04 - 2008/06. Theoretical and Experimental Studies of Enzyme Conformation, Energetics and Dynamics of CYP3A4.
2003 - 2005. Relationship between CYP3A4 gene polymorphisms, protein structure and activity in disease setting.
2002 - 2004. Structure and function of elicitins and their role in the infection of the cork oak by Phytophthora cinnamomi.
2001 - 2003. Molecular modelling of bacterial redox proteins: methodology and applications.
2000 - 2002. Structure-function relationships of serine hydrolases in non-conventional solvents.
1996 - 1998. Molecular modelling of electron-transfer proteins.
Produções
Martins, A.M.; Latham, J.A.; Martel, P.J.; Barr, I.; Iavarone, A.T.; Klinman, J.P.. 2019. "A two-component protease in Methylorubrum extorquens with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone". Journal of Biological Chemistry, 294 (41): 15025-15036. https://doi.org/10.1074/jbc.RA119.009684
Marques, C.L.; Fernández, I.; Viegas, M.N.; Cox, C.J.; Martel, P.; Rosa, J.; Cancela, M.L.; Laizé, V.. 2016. "Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: Molecular and evolutionary perspectives". Cellular and Molecular Life Sciences, 73 (4): 841-857. https://doi.org/10.1007/s00018-015-2024-x
Marques CL; Fernández I; Viegas MN; Cox CJ; Martel P; Rosa J; Cancela ML; Laizé V. 2015. "Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.". http://europepmc.org/abstract/med/26341094
Varanda CM; Machado M; Martel P; Nolasco G; Clara MI; Félix MR. 2015. "Correction: Genetic Diversity of the Coat Protein of Olive Mild Mosaic Virus (OMMV) and Tobacco Necrosis Virus D (TNV-D) Isolates and Its Structural Implications.". https://doi.org/10.1371/journal.pone.0128171
Silva G; Lima FP; Martel P; Castilho R. 2014. "Thermal adaptation and clinal mitochondrial DNA variation of European anchovy.". https://doi.org/10.1098/rspb.2014.1093
Varanda CM; Machado M; Martel P; Nolasco G; Clara MI; Félix MR. 2014. "Genetic diversity of the coat protein of Olive mild mosaic virus (OMMV) and Tobacco necrosis virus D (TNV-D) isolates and its structural implications.". https://doi.org/10.1371/journal.pone.0110941
Freedman, Holly; Martel, Paulo; Cruzeiro, Leonor. 2011. "Mixed quantum-classical dynamics of an amide-I vibrational excitation in a protein alpha-helix (vol 82, 174308, 2010)". Physical Review B, 84 (13). https://doi.org/10.1103/PhysRevB.84.139902
Teixeira VH; Ribeiro V; Martel PJ. 2010. "Analysis of binding modes of ligands to multiple conformations of CYP3A4.". https://doi.org/10.1016/j.bbapap.2010.06.008
Freedman, Holly; Martel, Paulo; Cruzeiro, Leonor. 2010. "Mixed quantum-classical dynamics of an amide-I vibrational excitation in a protein alpha-helix". Physical Review B, 82 (17). https://doi.org/10.1103/PhysRevB.82.174308
Tiago T; Martel P; Gutiérrez-Merino C; Aureliano M. 2007. "Binding modes of decavanadate to myosin and inhibition of the actomyosin ATPase activity.". https://doi.org/10.1016/j.bbapap.2007.02.004
Rodrigues ML; Archer M; Martel P; Miranda S; Thomaz M; Enguita FJ; Baptista RP; et al. 2006. "Crystal structures of the free and sterol-bound forms of beta-cinnamomin.". https://doi.org/10.1016/j.bbapap.2005.09.008
Laizé V; Martel P; Viegas CS; Price PA; Cancela ML. 2005. "Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates.". https://doi.org/10.1074/jbc.M500257200
Rodrigues ML; Archer M; Martel P; Jacquet A; Cravador A; Carrondo MA. 2002. "Structure of beta-cinnamomin, a protein toxic to some plant species.". https://doi.org/10.1107/S0907444902010107
Martel, P. J.; Rodrigues, L.; Cravador, A.. 2002. "Electrostatic calculations on fungal elicitins". Abstracts of Papers of the American Chemical Society, 223: C72-C72. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000176296801804&KeyUID=WOS:000176296801804
Baptista AM; Martel PJ; Soares CM. 1999. "Simulation of electron-proton coupling with a Monte Carlo method: application to cytochrome c3 using continuum electrostatics.". https://doi.org/10.1016/S0006-3495(99)77452-7
Martel PJ; Soares CM; Baptista AM; Fuxreiter M; Náray-Szabó G; Louro RO; Carrondo MA. 1999. "Comparative redox and pKa calculations on cytochrome c3 from several Desulfovibrio species using continuum electrostatic methods.". https://doi.org/10.1007/s007750050291
Soares CM; Martel PJ; Mendes J; Carrondo MA. 1998. "Molecular dynamics simulation of cytochrome c3: studying the reduction processes using free energy calculations.". https://doi.org/10.1016/S0006-3495(98)77882-8
Sebastião MJ; Martel P; Baptista A; Petersen SB; Cabral JM; Aires-Barros MR. 1997. "Predicting the partition coefficients of a recombinant cutinase in polyethylene glycol/phosphate aqueous two-phase systems.". https://doi.org/10.1002/(SICI)1097-0290(19971105)56:3<248::AID-BIT2>3.0.CO;2-J
Baptista AM; Martel PJ; Petersen SB. 1997. "Simulation of protein conformational freedom as a function of pH: constant-pH molecular dynamics using implicit titration.". https://doi.org/10.1002/(SICI)1097-0134(199704)27:4<523::AID-PROT6>3.3.CO;2-9
Soares, C. M.; Martel, P. J.; Carrondo, M. A.. 1997. "Theoretical studies on the redox-Bohr effect in cytochrome c(3) from Desulfovibrio vulgaris Hildenborough". Journal of Biological Inorganic Chemistry, 2 (6): 714-727. https://doi.org/10.1007/s007750050188
Petersen MT; Martel P; Petersen EI; Drabløs F; Petersen SB. 1997. "Surface and electrostatics of cutinases.". https://doi.org/10.1016/S0076-6879(97)84009-8
Baptista, A.M.; Martel, P.J.; Petersen, S.B.. 1997. "Simulation of protein conformational freedom as a function of pH: Constant-pH molecular dynamics using implicit titration". Proteins: Structure, Function and Genetics, 27 (4): 523-544. https://doi.org/10.1002/(SICI)1097-0134(199704)27:4<523::AID-PROT6>3.0.CO;2-B
Martel, P.J.; Baptista, A.; Petersen, S.B.. 1996. Protein Electrostatics. Vol. 2. https://doi.org/10.1016/S1387-2656(08)70016-4
Baptista, A.; Brautaset, T.; Drabløs, F.; Martel, P.; Valla, S.; Petersen, S.B.. 1995. "Electrostatic studies of carbohydrate active enzymes". 181-204. Vol. 10. https://doi.org/10.1016/S0921-0423(06)80103-6
Baptista, A.; Brautaset, T.; Drablos, F.; Martel, P.; Valla, S.; Petersen, S. B.. 1995. "Electrostatic studies of carbohydrate active enzymes". Editado por Petersen, S. B.; Svensson, B.; Pedersen, S., 181-204. Vol. 10. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:A1995BE87L00015&KeyUID=WOS:A1995BE87L00015
Anthonsen, H.W.; Baptista, A.; Drabløs, F.; Martel, P.; Petersen, S.B.; Sebastião, M.; Vaz, L.. 1995. Lipases and esterases: A review of their sequences, structure and evolution. Vol. 1. https://doi.org/10.1016/S1387-2656(08)70056-5
Martel, Paulo. 1994. "Protein Engineering". Suiça.
Anthonsen HW; Baptista A; Drabløs F; Martel P; Petersen SB. 1994. "The blind watchmaker and rational protein engineering.". https://doi.org/10.1016/0168-1656(94)90152-X
Pires MJ; Martel P; Baptista A; Petersen SB; Willson RC; Cabral JM. 1994. "Improving protein extraction yield in reversed micellar systems through surface charge engineering.". https://doi.org/10.1002/bit.260440702
Martel, Paulo. 1991. "Electrostatics of proteins". Estados Unidos.
