Silhueta de pessoa indiferenciada

Ana Grenha

Professor auxiliar
Faculdade de Ciências e Tecnologia
Centro de Ciências do Mar
Subsistema
Docentes Universitário
Unidade ID
Centro de Ciências do Mar
Unidade ID externa
Instituto de Investigação do Medicamento (iMed.ULisboa)
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Ana Margarida Moutinho Grenha is Assistant Professor at the Universidade do Algarve, Faculdade de Ciências e Tecnologia. Published 45 artigos in peer-reviewed journals mainly in the area of Pharmaceutics/Drug Delivery and Materials Science. She has published 7 book chapters and served as Guest Editor of two special issues. She authored 1 patent and has one provisional patent request. Has experience as coordinator and participant of research projects with competitive funding at national level, as well as experience in student supervision, 3 PhD students concluded (3 ongoing) and 13 MSc students concluded. Acts in the field of Health Sciences, with enphasis on Pharmaceutical Technology - Drug Delivery. In her Ciência Vitae CV the most frequent words in the context of scientific outputs are: Lung delivery; Pulmonary delivery; Drug delivery; Microparticles; Inhalable carriers; Nanoparticles; Spray-drying; Drug targeting; Polysaccharides.

Atividades

Atividades
2019/04. Entrevista (jornal / revista). Artigo de opinião na revista Visão Saúde, sob o título "Estamos perto de tratar a tuberculose com alfarroba, crustáceos e algas?". Visão Saúde.
2018/02/21 - Presente. Entrevista / Programa (rádio / tv). Participação no programa da Rádio Universitária do Algarve "Projetoscópio". Aplicações da goma de alfarroba na área da saúde.
2017/12. Entrevista (jornal / revista). Artigo de divulgação na Deco Proteste - Teste Saúde, com a reportagem "Investigação em Biomedicina". Deco Proteste - Teste Saúde.
2017/10/21 - Presente. Entrevista / Programa (rádio / tv). Participação no programa "Os dias do futuro", rádio Antena 1

. A goma de alfarroba como material promissor.
2017/09/21 - Presente. Entrevista / Programa (rádio / tv). Participação no programa "90 segundos de ciência", da rádio Antena 1

. Alfarroba algarvia pode ajudar a tratar tuberculose.
2021/12. Júri de grau académico. Biopharmaceutical formulations for dry powder inhalers. Arguente principal. Diana Alexandra Santana da Silva Fernandes (Doutoramento). Universidade de Lisboa Faculdade de Farmácia.
2021/12/08 - 2021/12/10. Arbitragem científica em conferência. Drug Delivery to the Lungs - DDL 2021.
2021/06. Júri de grau académico. Bioaccesibilidad de elementos inorgánicos en leguminosas y potitos ecológicos de base vegetal. Presidente do júri. Ana María Ramírez Ojeda (Doutoramento). Universidad de Córdoba.
2021/06/29. Apresentação oral de trabalho. Inhalable therapies - Fostering new applications in respiratory disease treatment. 8th BiotechHealth Annual Symposium: Biotech Talks - The Future is Now. University of Porto (Porto, Portugal).
2021/03. Júri de grau académico. Quality-by-design approach for the development of lipid-based nanosystems for anti-mycobacterial therapy. Arguente. Helena Rouco Taboada (Doutoramento). Universidade de Santiago de Compostela.
2018/10/01 - 2021/02/28. Orientação. Application of algae-based biomaterials for the preparation of particulate systems for the mucosal delivery of bioactive substances . Orientador de Noelia Flórez Fernández (pos-doc).
2020/12. Apresentação oral de trabalho. Konjac glucomannan microcarriers and macrophages: a promising interaction in lung diseases treatment. Drug Delivery to the Lungs Christmas Lectures – virtual format. Drug Delivery to the Lungs Conference.
2019/09 - 2020/12. Orientação. Synthesis of locust bean gum cationic derivatives for nanoparticles production by polyelectrolyte complexation.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Coorientador de Miguel Viegas Rodrigues.
2019/09 - 2020/12. Orientação. Application of experimental design in the preparation of chitosan/carrageenan nanoparticles by polyelectrolytic complexation: Study of the effect of salt addition.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Orientador de Inês Rocheta de Almeida Vasques da Silva.
2020/12/09 - 2020/12/11. Arbitragem científica em conferência. DDL Christmas Lectures. Aerosol Society.
2020/01/29 - 2020/12/11. Organização de evento. Drug Delivery to the Lungs (DDL) Christmas Lectures (2020). The Aerosol Society.
2020/11. Apresentação oral de trabalho. Terapêutica inalável da tuberculose: Um alinhamento da via de administração do fármaco com a via de infeção / Ihnalable therapy of tuberculosis: Matching the delivery route with the infection route. 36º Congresso de Pneumologia. Sociedade Portuguesa de Pneumologia (Albufeira, Portugal).
2020/02 - 2020/07. Arbitragem científica em conferência. Controlled Release Society Annual Meeting and Exposition. Controlled Release Society.
2020/07 - Presente. Orientação. Unveiling the potential of fucoidan-containing extracts of Laminaria ochroleuca as biomaterial composing the matrix of polyelectrolyte complexes.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Orientador de Carolina Afonso.
2020/04/03. Júri de grau académico. Drug encapsulation and controlled release via stimuli responsive nano and micro structured polymeric materials. Arguente. Nieves Iglesias Blanco (Doutoramento). Universidad de Sevilla.
2020/02. Júri de grau académico. Diseño de sistemas nanoparticulares lipídicos para co-administración de teofilina y ciprofloxacino en el tratamiento de la fibrosis quística. Arguente principal. María Oliva Guerra Morillo (Doutoramento). Universidad de Sevilla Facultad de Farmacia.
2020/01 - 2020/01. Arbitragem científica em conferência. Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS). Santiago de Compostela.
2014/01 - 2019/12. Orientação. Development of polysaccharide-based carriers for pulmonary tuberculosis therapy. Orientador de Susana Isabel Guerreiro Rodrigues.
2019/12/11 - 2019/12/13. Organização de evento. Organisation of the conference "Drug Delivery to the Lungs: DDL2019" (2019). The Aerosol Society.
2019/12/11 - 2019/12/13. Arbitragem científica em conferência. Drug Delivery to the Lungs 2019. Aerosol Society.
2019/09 - Presente. Orientação. Lipid nanocapsules as drug carriers.Mestrado em Oncobiologia (Mestrado). Orientador de Emanuel Duarte (pending defence only).
2019/09. Apresentação oral de trabalho. Inhalable therapy of pulmonary tuberculosis mediated by polysaccharide microparticles. 22nd International Symposium on Microencapsulation.
2019/09 - 2019/09. Arbitragem científica em conferência. 22nd International Symposium on Microencapsulation. Fundação Osvaldo Cruz.
2019/09. Júri de grau académico. Marine microalgae as sources of bioactive compounds with anti-inflammatory action . Arguente principal. Kovan Mohammed Ismael (Mestrado). Universidade do Algarve.
2019/02 - 2019/07. Orientação. Preparação e caracterização de nanopartículas de Fucoidano e Quitosano formadas por complexação polieletrolítica.Licenciatura em Ciências Biomédicas (Licenciatura/Bacharelato). Orientador de Rafaela Silvestre.
2015/09 - 2019/05. Membro de comissão. Comissão de auto-avaliação do curso de Ciências Farmacêuticas da Universidade do Algarve, encarregue de preparar o processo de acreditação do curso de Ciências Farmacêuticas junto da A3ES. Considerado como tempo da atividade o tempo desde início da preparação do relatório de auto-avaliação até receção da decisão da A3ES.. Membro. Universidade do Algarve.
2013/09 - 2019/02. Orientação. Nano and microparticles as carriers for alveolar macrophage targeting in pulmonary tuberculosis therapy.Doutoramento em Ciências Biomédicas (Doutoramento). Orientador.
2019/01. Júri de grau académico. Microencapsulated human albumin nanoparticles for drug delivery to the lungs. Arguente. Ayasha Patel (Doutoramento). King's College London.
2019/01. Apresentação oral de trabalho. Rifabutin formulations with improved therapeutic effect in murine tuberculosis model of infection: Influence of the administration route. 14th Spanish Society of Pharmaceutics and Pharmaceutical Technology Meeting.
2018/12 - 2018/12. Arbitragem científica em conferência. Drug Delivery to the Lungs 2018. Aerosol Society.
2018/06. Júri de grau académico. Establishment of a three-dimensional in vitro model of air-blood barrier to assess the translocation of nanoparticles targeted to the lung. Arguente principal. Ana Margarida Costa (Doutoramento). Universidade do Porto Faculdade de Farmácia.
2018/03 - Presente. Orientação. Study of the impact of dry powder insufflation over respiratory epithelial cells.Doutoramento em Medicina Regenerativa (Doutoramento). Orientador de Jorge Filipe Pontes.
2018/03. Júri de grau académico. Extraction and Purification of Bioactive Compounds from Sargassum muticum. Arguente principal. Noelia Flórez Fernández (Doutoramento). Universidade de Vigo - Campus Ourense.
2018/02. Apresentação oral de trabalho. Polysaccharide nanoparticles: Unveiling applications in mucosal drug delivery. nanoPT2018 International Conference.
2018/01 - 2018/01. Arbitragem científica em conferência. Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS). Universidade de Coimbra, Portugal.
2018/01 - Presente. Membro de associação. European Respiratory Society. Membro associado.
2018/01 - Presente. Membro de associação. Sociedade Portuguesa de Pneumologia. Membro associado.
2017/09 - 2017/09. Arbitragem científica em conferência. 21st International Symposium on Microencapsulation. Faro, Portugal.
2017/09/27 - 2017/09/29. Organização de evento. Organisation of the 21st International Symposium on Microencapsulation, passed in testimony at the previous conference in Boston (2017). Universidade do Algarve.
2017/07. Apresentação oral de trabalho. Inhalable therapy of pulmonary tuberculosis mediated by polysaccharide microparticles. Global Conference on Pharmaceutics and Drug Delivery Systems.
2017/06. Apresentação oral de trabalho. Inhalable dry powders for pulmonary tuberculosis therapy. Workshop on Innovative Drug Delivery. Université Lyon 1 (Lyon, França).
2017/06. Apresentação oral de trabalho. Inhalable dry powders for pulmonary tuberculosis therapy. Workshop on Innovative Drug Delivery. Université Claude Bérnard 1 (Lyon, França).
2017/03 - Presente. Orientação. Konjac glucomannan microcarriers: an application in the treatment of pulmonary tuberculosis.Doutoramento em Ciências Biomédicas (Doutoramento). Orientador de Filipa Raquel Horta Guerreiro (pending defence).
2017/03. Júri de grau académico. SLN spray drying in tuberculosis treatment. Arguente. Diana Gaspar (Doutoramento). Universidade de Lisboa Faculdade de Farmácia.
2015 - 2016. Orientação. Chitosan/dextran sulfate nanoparticles: stability evaluation and assessment of the effect of different acidic media on nanoparticle preparation.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Orientador de Jorge Filipe Pontes.
2016/12. Júri de grau académico. Characterization of the effect of cartilage acidic protein (CRTAC) on human monocytes THP-1 cells . Arguente principal. André Coelho (Mestrado). Universidade do Algarve.
2016/11 - Presente. Comissão de avaliação. Comissão de Avaliação Externa da A3ES ( Agência de Avaliação e Acreditação do Ensino Superior)
External evaluation comission from A3ES (the Portuguese Agency for Evaluation and Accreditation of Higher Education).
2016/06. Júri de grau académico. Enhancement of non-viral transfection efficiency with nuclear localization signal peptides. Arguente principal. Joana Morais (Mestrado). Universidade do Algarve.
2016/04. Júri de grau académico. Efeito da microgravidade simulada em fibroblastos de pele humana. Arguente. Patricia Bellicanta (Mestrado). Pontifícia Universidade Católica do Rio Grande do Sul.
2014 - 2015. Orientação. Microencapsulation of antitubercular drugs for application in tuberculosis treatment. Orientador.
2014 - 2015. Orientação. Spray-dried microparticles aimed at pulmonary delivery of antitubercular drugs. Orientador.
2014 - 2015. Orientação. Locust bean gum-based microparticles for pulmonary delivery of antibiotics. Orientador.
2015/12. Júri de grau académico. Combination of nano and microcarriers for stem cell therapy of Huntington's disease: new regenerative medicine strategy. Arguente principal. Emilie André (Doutoramento). Université d'Angers;Universidade de Santiago de Compostela.
2015/07. Júri de grau académico. Towards a new approach to phenylketonuria treatment: stabilization of phenylalanine hydroxylase using nanobiomaterials. Arguente. Paulo Roque Lino (Doutoramento). Universidade de Lisboa Faculdade de Farmácia.
2015/01 - Presente. Orientação. Inhalable natural polymeric microparticles for pulmonary tuberculosis therapy.Doutoramento em Ciências Biomédicas (Doutoramento). Orientador de Flavia Musacchio (pending defence only).
2013 - 2014. Orientação. Polymeric microparticles for local pulmonary drug delivery.Mestrado em Ciências Biomédicas (Mestrado). Orientador.
2013 - 2014. Orientação. Development of locust bean gum nanoparticles for protein delivery. Orientador.
2013/12. Júri de grau académico. Synthesis and evaluation of polymer nanoparticles for delivery in RPE cells. Arguente principal. Diogo Bitoque (Mestrado). Universidade do Algarve.
2013/03. Júri de grau académico. Effects of active pharmaceutical ingredients in mussel mytilus galloprovincialis. Vogal. Maria Margarida Ramos González Rey (Doutoramento). Universidade do Algarve.
2011 - 2012. Orientação. Encapsulamento de aminoácidos hidrolisados em lipossomas.Mestrado em Biotecnologia (Mestrado). Orientador.
2011 - 2012. Orientação. Desenvolvimento de sistemas nanoparticulados de fucoidan/quitosano para administração de proteínas por vias mucosas. Orientador.
2012/05. Apresentação oral de trabalho. Polysaccharide-based nanoparticles for nasal and pulmonary delivery of biopharmaceuticals. II Conference ShareBiotech: New approaches in biopharmaceutical delivery and building networks in biotechnology.
2012/02. Apresentação oral de trabalho. Polysaccharides as flexible materials for nanoparticles formulation aimed at mucosal protein delivery. 2nd World Congress on Pharmaceutics and Novel Drug Delivery Systems.
2011/12. Júri de grau académico. Synthesis of polymer nanoparticles sensitive to pH for DNA delivery in intracellular environment. Arguente principal. Eduardo Lopes (Mestrado). Universidade do Algarve.
2011/09. Júri de grau académico. Self-assembled nanoparticles as new smart contrast agents for magnetic resonance imaging. Arguente. Sonia N. Alqadi (Doutoramento). Universidade de Santiago de Compostela.
2011/01 - 2011/07. Orientação. Improving nutrition of fish larvae using innovative microencapsulation techniques. Orientador de Wilson Pinto (post-doc).
2011/01. Júri de grau académico. Self-assembled nanoparticles as new smart contrast agents for magnetic resonance imaging. Arguente principal. Teresa Simão (Mestrado). Universidade do Algarve.
2009 - 2010. Orientação. Caracterização das propriedades da goma de alfarroba de relevância para aplicação farmacêutica. Orientador de Marita Dionísio.
2005 - Presente. Membro de associação. Spanish Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS) . Membro associado.

Projetos

Projetos
2022/04/01 - 2024/03/31. GERMROS: The imprinting characteristics of spermatogonia antioxidant capacity and their role in oxidative stress tolerance, Projetos em todos os domínios científicos. Investigador. Centro de Ciências do Mar.
2021/04/01 - 2023/03/31. NUTRISAFE - Exploring a novel and sustainable sea-based diet supplement to promote longevity and quality of life in a pandemic era, Programa Operacional CRESC Algarve 2020. Investigador. Centro de Ciências do Mar; Universidade do Algarve.
2019/01 - 2021/12. NANOSPEED - Nanoencapsulation of drugs using biopolymers with specific abilities for drug delivery, Programa Pessoa. Investigador responsável. Centro de Ciências do Mar.
2013/04/01 - 2015/12/31. Fighting TB: Development of microparticulate systems for alveolar macrophage targeting in tuberculosis therapy. Investigador responsável. Universidade do Algarve.
2012/01 - 2014/12. ZEBRAFEEDS - Development of reference diets for the padronisation of zebra fish nutrition in biomedical studies, QREN SI I&DT. Investigador. Centro de Ciências do Mar.
2011/01 - 2013/12. miPS and hiPS - Reprogramming mice and human adult cells. Investigador. Universidade do Algarve.
2010/01 - 2013/12. NanoPulmoGen - Sistemas nanotransportadores microencapsulados para liberación pulmonar de material genético, Marco del Plan Nacional de I+D+I 2009. Outra. Universidade de Santiago de Compostela - Faculdade de Farmácia.
2010/01/01 - 2013/07. Development of non-viral vectors for ocular gene therapy, 3599-PPCDT. Investigador. Universidade do Algarve.
2010/01/01 - 2013/06/30. EncapsDevice – Development of polymeric nanosctructures for nasal and pulmonary delivery of peptides and proteins. Investigador responsável. Universidade do Algarve.
2010/09/01 - 2013/01/31. MICALA - Development of a microencapsulated feed for fish larvae, QREN I&DT Co-Promoção 2010-2012. Investigador responsável. Universidade do Algarve.
2010/01 - 2012/12. Nanotransportadores microencapsulados para administración pulmonar de material genético. Outra. Universidade de Santiago de Compostela - Faculdade de Farmácia.

Produções

Greque Morais, Etiele; Pontes, JF; Grenha, Ana; Varela, Joao; Barreira, Luísa. 2022. "Microalgae applications in nanotechnology: an outstanding tool for nanocompounds synthesis and bioproducts obtention". Vol. 10. Apple Academic Press/CRC Press.
Grenha, Ana; Rodrigues, Susana; Pereira, Filipa; Alves, Ana Bernardina Cotrim Dias; Guerreiro, Filipa. 2022. "Processo para a produção de micropartículas de polissacáridos direcionadas para os macrófagos alveolares, obtenção das micropartículas e uso das mesmas". Portugal. Concedida/Emitida.
Grenha, Ana; Bebianno, MJ; Rocha, TL; Pontes, JF; Amaral, AC. 2021. "Potential ecotoxicological risk of nanopharmaceuticals in the aquatic environment". Em Environmental Impact of Nanopharmaceuticals, 289-317. Vol. 2. Springer.
Grenha, Ana; Noelia Flórez-Fernández; Maria Dolores Torres; Domínguez, Herminia. 2021. Formulation of polymeric nanoparticles using a bioactive extract of the invasive brown seaweed Sargassum muticum. Em 1st Greenering International Conference (virtual format).
Susana Rodrigues; Ludmylla Cunha; Julia Kollan; Paul Robert Neumann; Ana M. Rosa da Costa; Lea Ann Dailey; Grenha, Ana. 2021. "Biological evaluation of chondroitin sulfate microparticles aimed at pulmonary tuberculosis therapy". European Journal of Pharmaceutics and Biopharmaceutics, 163: 171-178.
Annalisa Rosso; Yves Chevalier; Jacqueline Sidi-Boumedine; Grenha, Ana; Filipa Guerreiro; Adem Gharsallaoui; Veronica La Padula; et al. 2021. "Nanocomposite sponges for enhancing intestinal residence time following oral administration". Journal of Controlled Release, 333: 579-592.
Flórez-Fernández, Noelia; Álvarez-Viñas, M; Torres, MD; Domínguez, Herminia; Grenha, Ana. 2021. Exploring the ability to produce polymeric nanoparticles using extracts obtained from Chondrus crispus. Em Seaweed for Health.
Grenha, Ana; Flórez-Fernández, Noelia; Afonso, Carolina; Guerreiro, Filipa Raquel Horta; Pontes, Jorge Filipe Rodrigues; Torres, MD; Domínguez, Herminia. 2021. Antiproliferative effect of the extracts obtained from Himanthalia elongata and their ability to produce polymeric nanoparticles. Em CINBIO Conference.
Guerreiro, Filipa Raquel Horta; Swedrowska, Magda; Patel, R; Flórez-Fernández, Noelia; Torres, MD; Rosa da Costa, AM; Forbes, Ben; Grenha, Ana. 2021. "Engineering of konjac glucomannan into respirable microparticles for delivery of antitubercular drugs".
2021. "Prototype of dry powder aerosolisation device for in vitro assays".
Pontes, Jorge F.; Diogo, Hermínio; Conceição, Eusébio; Musacchio, Flavia; Borges dos Santos, Rui M.; Grenha, Ana. 2021. "Development of a prototype of an aerosolization device for dry powders to improve in vitro cell-based assays in the context of lung delivery". Trabalho apresentado em Drug Delivery to the Lungs 2021, Reino Unido,dezembro, 2021.
Pontes; Grenha. 2020. "Multifunctional Nanocarriers for Lung Drug Delivery". Nanomaterials, 10 (2). https://doi.org/10.3390/nano10020183
Grenha, Ana; Alves, Ana D.; Guerreiro, Filipa; Pinho, Jacinta; Simões, Sandra; Almeida, António José; Gaspar, Maria Manuela. 2020. "Inhalable locust bean gum microparticles co-associating isoniazid and rifabutin: Therapeutic assessment in a murine model of tuberculosis infection". European Journal of Pharmaceutics and Biopharmaceutics, 147: 38-44. https://doi.org/10.1016/j.ejpb.2019.11.009
Guerreiro, Filipa Raquel Horta; Swedrowska, M; Rosa da Costa, Ana M.; Forbes, Ben; Grenha, Ana. 2020. Aerodynamic characterisation of konjac glucomannan microcarriers targeted to the alveolar region through inhalation. Em Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), XIII Spanish-Portuguese Conference on Controlled Drug Delivery.
Pontes, Jorge Filipe Rodrigues; Braz, Luis; Rosa da Costa, Ana M; Almouazen, E; Lollo, Giovanna; Grenha, Ana. 2020. Stability evaluation of sulphated locust bean gum-coated lipid nanocapsules. Em Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), XIII Spanish-Portuguese Conference on Controlled Drug Delivery.
Rodrigues; da Costa; Flórez-Fernández; Torres; Faleiro; Buttini; Grenha. 2020. "Inhalable Spray-Dried Chondroitin Sulphate Microparticles: Effect of Different Solvents on Particle Properties and Drug Activity". Polymers, 12 (2). https://doi.org/10.3390/polym12020425
Flórez-Fernández, Noelia; Pontes, Jorge F.; Domínguez, Herminia; Grenha, Ana. 2020. Evaluation of nanosystems based on biopolymers: Fucoidan from the edible brown seaweed Laminaria japonica and chitosan. Em Spanish-Portuguese Local Chapter of the Controlled Release Society (SPLC-CRS), XIII Spanish-Portuguese Conference on Controlled Drug Delivery.
Noelia Flórez-Fernández; Milena Álvarez-Viñas; Filipa Guerreiro; María Dolores Torres; Ana Grenha; Herminia Domínguez. 2020. "Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles". Marine Drugs, 18 (7): 336-336. https://doi.org/10.3390/md18070336
Susana Rodrigues; Ludmylla Cunha; João Rico; Ana M. Rosa da Costa; António J. Almeida; M. Leonor Faleiro; Francesca Buttini; Ana Grenha. 2020. "Carrageenan from red algae: an application in the development of inhalable tuberculosis therapy targeting the macrophages". Drug Delivery and Translational Research. https://doi.org/10.1007/s13346-020-00799-0
Grenha, Ana; Noelia Flórez-Fernández; Maria Dolores Torres; Luis Braz; EP Loret; Herminia Domínguez. 2020. "Seaweed and Sea Anemones Proteins as a Source of New Pharmaceutical Active Principles". Em Marine Niche: Applications in Pharmaceutical Sciences, 203-219. Springer Singapore.
Grenha, Ana; Jorge F. Pontes; Emanuel Duarte; Flórez-Fernández, Noelia; Joao Rico; Joana Cruz; Giovanna Lollo; Domínguez, Herminia. 2020. Fucoidan-coated lipid nanocapsules encapsulating a model drug for lung drug delivery. Em Drug Delivery to the Lungs Christmas Lectures (virtual format).
Pontes, JF; Duarte, Emanuel; Flórez-Fernández, Noelia; Rico, João André Martins; Cruz Silva, Joana; Lollo, G; Domínguez, Herminia; Grenha, Ana. 2020. "Fucoidan-coated lipid nanocapsules encapsulating a model drug for lung drug delivery". Trabalho apresentado em Drug Delivery to the Lungs - DDL 2020, apresentado por Pontes, Jorge F., Reino Unido,dezembro, 2020.
Guerreiro, Filipa; Pontes, Jorge F.; Rosa da Costa, Ana M.; Grenha, Ana. 2019. "Spray-drying of konjac glucomannan to produce microparticles for an application as antitubercular drug carriers". Powder Technology, 342: 246-252. https://doi.org/10.1016/j.powtec.2018.09.068
Cunha, Ludmylla; Rodrigues, Susana; Rosa da Costa, Ana M.; Faleiro, Leonor; Buttini, Francesca; Grenha, Ana. 2019. "Inhalable chitosan microparticles for simultaneous delivery of isoniazid and rifabutin in lung tuberculosis treatment". Drug Development and Industrial Pharmacy, 45 (8): 1313-1320. https://doi.org/10.1080/03639045.2019.1608231
Grenha, Ana. 2019. "Multifunctional Nanocarriers for Drug Delivery". Nanomaterials. https://www.mdpi.com/journal/nanomaterials/special_issues/Nanocarrier_Drug
Pontes, Jorge Filipe Rodrigues; Braz, Luis; Guerreiro, Filipa Raquel Horta; Rosa da Costa, Ana M; Almouazen, E; Lollo, Giovanna; Grenha, Ana. 2019. Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carrier. Em DDL30-2019 Drug Delivery to the Lungs Conference. https://doi.org/10.2118/198789-ms
Guerreiro, Filipa Raquel Horta; Swedrowska, M; Rosa da Costa, Ana M; Grenha, Ana; Forbes, Ben. 2019. Konjac glucomannan-based microcarriers to target macrophage. Em DDL30-2019 Drug Delivery to the Lungs Conference.
Grenha, Ana; Pontes, Jorge F.; Braz, Luis; Rosa da Costa, Ana M; Almouazen, E; Lollo, Giovanna. 2019. Development of nanocapsules using a locust bean gum sulfate derivative. Em 22nd International Symposium on Microencapsulation.
Jorge F. Pontes; Luis Braz; Filipa Guerreiro; Ana M. Rosa da Costa; Grenha, Ana; Giovanna Lollo; Eyad Almouazen. 2019. "Sulphated locust bean gum-coated lipid nanocapsules as potential lung delivery carriers". Trabalho apresentado em Drug Delivery to the Lungs - DDL 2019, apresentado por Jorge F. Pontes, Reino Unido,dezembro, 2019, A15-A15.
Filipa Guerreiro; Magda Swedrowska; AM Rosa da Costa; Ben Forbes; Grenha, Ana. 2019. "In vitro behaviour of konjac glucomannan microparticles aimed at pulmonary tuberculosis therapy". Trabalho apresentado em Drug Delivery to the Lungs - DDL 2019, apresentado por Filipa Guerreiro, Reino Unido,dezembro, 2019, A12-A12.
Braz, Luis; Grenha, Ana; Corvo, Marta C.; Lourenço, João Paulo; Ferreira, Domingos; Sarmento, Bruno; Rosa da Costa, Ana M.. 2018. "Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles". Carbohydrate Polymers, 181: 974-985. https://doi.org/10.1016/j.carbpol.2017.11.052
Roberto, V. P.; Martins, G.; Pereira, A.; Rodrigues, S.; Grenha, A.; Pinto, W.; Cancela, M. L.; Dias, J.; Gavaia, P. J.. 2018. "Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio
(Hamilton, 1822) larvae: From morphological analysis to osteogenic markers". Journal of Applied Ichthyology, 34 (2): 512-523. https://doi.org/10.1111/jai.13664
Cunha, Ludmylla; Rodrigues, Susana; Rosa da Costa, Ana; Faleiro, M; Buttini, Francesca; Grenha, Ana. 2018. "Inhalable Fucoidan Microparticles Combining Two Antitubercular Drugs with Potential Application in Pulmonary Tuberculosis Therapy". Polymers, 10 (6). https://doi.org/10.3390/polym10060636
Cunha, Ludmylla; Rosa da Costa, Ana M.; Lourenço, João P.; Buttini, Francesca; Grenha, Ana. 2018. "Spray-dried fucoidan microparticles for pulmonary delivery of antitubercular drugs". Journal of Microencapsulation, 35 (4): 392-405. https://doi.org/10.1080/02652048.2018.1513089
Braz, Luis; Raimundo, Pedro; Rosa da Costa, Ana M; Grenha, Ana. 2018. Locust Bean Gum-only nanoparticles for mucosal protein delivery. Em CRS Annual Meeeting and Exposition.
Pontes, Jorge F.; Cordeiro, Clara; Grenha, Ana. 2018. Design of experiments to study the stability of chitosan/dextran sulfate (CS/DS) nanoparticles. Em CRS Annual Meeting and Exposition.
Guerreiro, Filipa Raquel Horta; Rosa da Costa, Ana M; Faleiro, Maria Leonor; Grenha, Ana. 2018. Uptake of konjac glucomannan microparticles by macrophage-like cells for an application in tuberculosis therapy. Em CRS Annual Meeting and Exposition.
Grenha, Ana. 2017. "Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery.". Molecular pharmaceutics, 14 (9): 2977-2990. https://doi.org/10.1021/acs.molpharmaceut.7b00169
Grenha, Ana. 2017. "Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles.". International journal of pharmaceutics, 529 (1-2): 433-441. https://doi.org/10.1016/j.ijpharm.2017.06.088
Braz L; Grenha A; Ferreira D; Rosa da Costa AM; Gamazo C; Sarmento B. 2017. "Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization.". International Journal of Biological Macromolecules, 96: 786-797. https://doi.org/10.1016/j.ijbiomac.2016.12.076
Guerreiro, Filipa; Rosa da Costa, AM; Faleiro, ML; Grenha, Ana. 2017. Konjac glucomannan-based microcarriers to target macrophages. Em DDL28-2017 Drug Delivery to the Lungs Conference.
Rodrigues, Susana; Rosa da Costa, AM; Buttini, Francesca; Grenha, Ana. 2017. Chondroitin sulphate microparticles: Application in macrophage targeting for tuberculosis treatment. Em DDL28-2017 Drug Delivery to the Lungs Conference.
Araújo, Nuna; Viegas, CSB; Pontes, JF; Magalhães, J; Blanco, FJ; Macedo, AL; Grenha, Ana; Simes, DC. 2017. Nano-encapsulation of GLA-rich protein (GRP) and potential added value as a therapeutic agent for osteoarthritis. Em 21st International Symposium on Microencapsulation.
Gaspar, MM; Nave, M; Simões, Sandra; Almeida, AJ; Alves, AB; Grenha, Ana. 2017. . Improved therapeutic effect of rifabutin/isoniazid microparticles for the treatment of tuberculosis following pulmonary administration. Em 21st International Symposium on Microencapsulation.
Grenha, Ana; Pontes, JF; Cordeiro, C. 2017. Chitosan/dextran sulfate (CS/DS) nanoparticles: Stability evaluation using factorial design. Em 21st International Symposium on Microencapsulation.
Musacchio, Flavia; Guerreiro, Filipa; Cruz, Rui; Grenha, Ana. 2017. Spray-drying optimization to produce xanthan gum microparticles. Em 21st International Symposium on Microencapsulation.
Guerreiro, Filipa; Rosa da Costa, AM; Faleiro, ML; Grenha, A.. 2017. Cytotoxic evaluation and macrophage activation ability of konjac glucomannan microparticles. Em 21st International Symposium on Microencapsulation.
Rodrigues, Susana; Rosa da Costa, AM; Buttini, Francesca; Grenha, Ana. 2017. Starch/carrageenan microparticles for lung delivery of antitubercular drugs. Em 21st International Symposium on Microencapsulation.
Cunha, Ludmylla Costa; Rodrigues, Susana; Rosa da Costa, AM; Buttini, Francesca; Grenha, Ana. 2017. Inhalable fucoidan microparticles as tool in tuberculosis therapy. Em 21st International Symposium on Microencapsulation.
Filipa Guerreiro; Ana M. Rosa da Costa; M. Leonor Faleiro; Grenha, Ana. 2017. "Konjac glucomannan microparticles for antitubercular drug delivery by inhalation". Trabalho apresentado em Drug Delivery to the Lungs, apresentado por Filipa Guerreiro, Edinburgh, Reino Unido,dezembro, 2017, A27-A28.
Susana Rodrigues; Francesca Buttini; Lea Ann Dailey; ML Faleiro; AM Rosa da Costa; Grenha, Ana. 2017. "Chondroitin sulphate microparticles as antitubercular drug carriers". Trabalho apresentado em Drug Delivery to the Lungs - DDL2017, apresentado por Susana Rodrigues, Edinburgh, Reino Unido,dezembro, 2017, A27-A27.
Cunha L; Grenha A. 2016. "Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications.". Marine Drugs, 14 (3). https://doi.org/10.3390/md14030042
Ana Alves; Joana Cavaco; Filipa Guerreiro; João Lourenço; Ana Rosa da Costa; Ana Grenha. 2016. "Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles". Molecules, 21 (6): 702-702. https://doi.org/10.3390/molecules21060702
Dionísio M; Braz L; Corvo M; Lourenço JP; Grenha A; Rosa da Costa AM. 2016. "Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation.". International Journal of Biological Macromolecules, 86: 129-138. https://doi.org/10.1016/j.ijbiomac.2016.01.054
Grenha, Ana; Alves,AB; Rodrigues, Susana; Pereira, Filpa; Cunha, Ludmylla Costa; Guerreiro, Filipa. 2016. "Process for producing polysaccharide microparticles for alveolar macrophages targeting, microparticles obtained therein and use thereof WO 2016/174573". Portugal. Pendente.
Cunha, Ludmylla Costa; Rosa da Costa, AM; Grenha, Ana. 2016. "Inhalable chitosan microparticles as tools in tuberculosis therapy". Trabalho apresentado em Drug Delivery to the Lungs - DDL2016, Edimburgh, Reino Unido,dezembro, 2016, A15-A15.
Musacchio, Flavia; Grenha, Ana. 2016. "Dextran sulfate microparticles encapsulating isoniazid and/or rifabutin as carriers for pulmonary tuberculosis therapy". Trabalho apresentado em Drug Delivery to the Lungs - DDL2016, Edimburgh, Reino Unido,dezembro, 2016, A20-A21.
Rodrigues, Susana; Rosa da Costa, AM; Grenha, Ana. 2016. "Chondroitin sulphate microparticles for tuberculosis treatment: A way to target macrophages". Trabalho apresentado em Drug Delivery to the Lungs - DDL2016, Reino Unido,dezembro, 2016, A21-A22.
Susana Rodrigues; Clara Cordeiro; Begoña Seijo; Carmen Remuñán-López; Ana Grenha. 2015. "Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation". Carbohydrate Polymers, 123: 369-380. https://doi.org/10.1016/j.carbpol.2015.01.048
Rodrigues, S.; Cardoso, L.; da Costa, A.M.R.; Grenha, A.. 2015. "Biocompatibility and stability of polysaccharide polyelectrolyte complexes aimed at respiratory delivery". Materials, 8 (9): 5647-5670. https://doi.org/10.3390/ma8095268
dos Santos MA; Grenha A. 2015. "Polysaccharide nanoparticles for protein and Peptide delivery: exploring less-known materials.". Advances in Protein Chemistry and Structural Biology, 98: 223-261. https://doi.org/10.1016/bs.apcsb.2014.11.003
Rodrigues S; Grenha A. 2015. "Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy.". Current Pharmaceutical Design, 21 (33): 4869-4887. https://doi.org/10.2174/1381612821666150820103910
Grenha A. 2015. "Editorial: Exploring the Role of Polysaccharides in Drug Delivery.". Current Pharmaceutical Design, 21 (33). https://doi.org/10.2174/1381612821999150903143853
Grenha, Ana. 2015. "Exploring the role of polysaccharides in drug delivery". Current Pharmaceutical Design, 21 (33). https://www.ingentaconnect.com/content/ben/cpd/2015/00000021/00000033;jsessionid=51gfj8m9v424v.x-ic-live-03
Perestrelo AR; Grenha A; Rosa da Costa AM; Belo JA. 2014. "Locust bean gum as an alternative polymeric coating for embryonic stem cell culture.". Materials Science and Engineering C, 40: 336-344. https://doi.org/10.1016/j.msec.2014.04.022
Nunes, R.; Rodrigues, S.; Pasko, P.; Tyszka-Czochara, M.; Grenha, A.; De Carvalho, I.S.. 2014. "Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection". Industrial Crops and Products, 52: 99-104. https://doi.org/10.1016/j.indcrop.2013.10.015
Almeida, A.J.; Grenha, A.. 2014. "Technosphere®: An inhalation system for pulmonary delivery of biopharmaceuticals". Em Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Vol. 9781461495. https://doi.org/10.1007/978-1-4614-9524-6_22
Grenha A; Rodrigues S. 2013. "Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery.". Therapeutic Delivery, 4 (11). https://doi.org/10.4155/tde.13.99
Costa, H.; Grenha, A.. 2013. "Natural carriers for application in tuberculosis treatment". Journal of Microencapsulation, 30 (3): 295-306. https://doi.org/10.3109/02652048.2012.726283
Al-Qadi, S.; Grenha, A.; Remuñán-López, C.. 2012. "Chitosan and its derivatives as nanocarriers for siRNA delivery". Journal of Drug Delivery Science and Technology, 22 (1): 29-42. https://doi.org/10.1016/S1773-2247(12)50003-1
Grenha, A.. 2012. "Chitosan nanoparticles: A survey of preparation methods". Journal of Drug Targeting, 20 (4): 291-300. https://doi.org/10.3109/1061186X.2011.654121
Rodrigues, S.; Costa, A.M.R.D.; Grenha, A.. 2012. "Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios". Carbohydrate Polymers, 89 (1): 282-289. https://doi.org/10.1016/j.carbpol.2012.03.010
Dionísio, M.; Grenha, A.. 2012. "Locust bean gum: Exploring its potential for biopharmaceutical applications". Journal of Pharmacy and Bioallied Sciences, 4 (3): 175-185. https://doi.org/10.4103/0975-7406.99013
Rodrigues S; Dionísio M; López CR; Grenha A. 2012. "Biocompatibility of chitosan carriers with application in drug delivery.". Journal of Functional Biomaterials, 3: 615-641. https://doi.org/10.3390/jfb3030615
Al-Qadi, S.; Grenha, A.; Carrión-Recio, D.; Seijo, B.; Remuñán-López, C.. 2012. "Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations". Journal of Controlled Release, 157 (3): 383-390. https://doi.org/10.1016/j.jconrel.2011.08.008
Al-Qadi, S.; Grenha, A.; Remuñán-López, C.. 2012. "Chitosan-Based Systems for Mucosal Delivery of Biopharmaceuticals". Chitosan-Based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics, 181-209. https://doi.org/10.1002/9781119962977.ch11
Grenha, A.. 2012. "Systemic delivery of biopharmaceuticals: Parenteral forever?". Journal of Pharmacy and Bioallied Sciences, 4 (2). https://doi.org/10.4103/0975-7406.94807
Grenha, Ana. 2012. "Chitosan-based systems for biopharmaceuticals mucosal delivery". Em Chitosan-based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics. New York, Estados Unidos: John Wiley and Sons.
Grenha, A.. 2011. "The era of nanomedicine". Journal of Pharmacy and Bioallied Sciences, 3 (2). https://doi.org/10.4103/0975-7406.80757
Al-Qadi, S.; Grenha, A.; Remuñán-López, C.. 2011. "Microspheres loaded with polysaccharide nanoparticles for pulmonary delivery: Preparation, structure and surface analysis". Carbohydrate Polymers, 86 (1): 25-34. https://doi.org/10.1016/j.carbpol.2011.03.022
Braz, L.; Dionísio, M.; Grenha, A.. 2011. "Chitosan-based nanocarriers: Effective vehicles for mucosal protein delivery". Em Chitosan-based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875852625&partnerID=MN8TOARS
Braz, L.; Rodrigues, S.; Fonte, P.; Grenha, A.; Sarmento, B.. 2011. "Mechanisms of chemical and enzymatic chitosan biodegradability and its application on drug delivery". Em Biodegradable Polymers: Processing, Degradation and Applications. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891990706&partnerID=MN8TOARS
Grenha, A.; Al-Qadi, S.; Seijo, B.; Remuñán-López, C.. 2010. "The potential of chitosan for pulmonary drug delivery". Journal of Drug Delivery Science and Technology, 20 (1): 33-43. https://doi.org/10.1016/S1773-2247(10)50004-2
Grenha, A.; Gomes, M.E.; Rodrigues, M.; Santo, V.E.; Mano, J.F.; Neves, N.M.; Reis, R.L.. 2010. "Development of new chitosan/carrageenan nanoparticles for drug delivery applications". Journal of Biomedical Materials Research - Part A, 92 (4): 1265-1272. https://doi.org/10.1002/jbm.a.32466
Carvalho, E.L.S.; Grenha, A.; Remuñán-López, C.; Alonso, M.J.; Seijo, B.. 2009. "Chapter 15 Mucosal Delivery of Liposome-Chitosan Nanoparticle Complexes". Methods in Enzymology, 465 (C): 289-312. https://doi.org/10.1016/S0076-6879(09)65015-1
Grenha, A.; Remuñán-López, C.; Carvalho, E.L.S.; Seijo, B.. 2008. "Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins". European Journal of Pharmaceutics and Biopharmaceutics, 69 (1): 83-93. https://doi.org/10.1016/j.ejpb.2007.10.017
Grenha A; Seijo B; Serra C; Remuñán-López C. 2008. "Surface characterization of lipid/chitosan nanoparticles assemblies, using X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry.". http://europepmc.org/abstract/med/18468083
Grenha, A.; Grainger, C.I.; Dailey, L.A.; Seijo, B.; Martin, G.P.; Remuñán-López, C.; Forbes, B.. 2007. "Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro". European Journal of Pharmaceutical Sciences, 31 (2): 73-84. https://doi.org/10.1016/j.ejps.2007.02.008
Grenha, A.; Seijo, B.; Serra, C.; Remuñán-López, C.. 2007. "Chitosan nanoparticle-loaded mannitol microspheres: Structure and surface characterization". Biomacromolecules, 8 (7): 2072-2079. https://doi.org/10.1021/bm061131g
Grenha, A.; Seijo, B.; Remuñán-López, C.. 2005. "Microencapsulated chitosan nanoparticles for lung protein delivery". European Journal of Pharmaceutical Sciences, 25 (4-5): 427-437. https://doi.org/10.1016/j.ejps.2005.04.009
 

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