Luísa Barreira
Professor associado
Faculdade de Ciências e Tecnologia
Centro de Ciências do Mar
Subsistema
Docentes Universitário
Unidade ID
Centro de Ciências do Mar
Unidade ID externa
Centro de Ciências do Mar do Algarve (CCMAR)
Regime
Exclusividade
Vínculo
CT em Funções Públicas por tempo indeterminado
Luísa Barreira, PhD in Environmental Sciences and Technologies - Aquatic Environment, Assistant Professor of the Chemistry and Pharmacy Department of the Faculty of Sciences and Technology of the University of Algarve. She is a senior researcher of CCMAR, and a member of the GreenCoLAB, for I+D+I of Biotechnological Applications of Marine Organisms including microalgae as bioproducers (e.g. phospholipids, polyunsaturated fatty acids, pigments and bioactive natural products) as well as for wastewater treatment and other marine organisms (e.g. seaweeds and halophyte plants) as sources of ingredients for food and feed. She has participated in fifteen projects, nine involving microalgae and is currently the Principal Investigator of the project GreenTreat (An Integrated, Sustainable Process for the Tertiary Treatment of Urban Wastewater using Microalgae in the Algarve region; ALG-01-0145-FEDER-031567, 2018-2021) and the institutional (CCMAR) coordinator of the project ALGAE4IBD from Nature to Bedside - Algae Based Bio Compound for Prevention and Treatment of Inflammation, Pain and IBD. She has supervised 4 PhD students and is currently supervising 2 more. She has 93 papers published in peer-reviewed journals with over 3200 citations with a cumulative h-index of 33 (in Scopus).
Atividades
Atividades
2021/10 - 2022/02. Orientação. Skeletonema costatum como fonte de compostos bioactivos com capacidade antioxidante e de inibição da enzima conversora da angiotensina.Bioquímica (Licenciatura/Bacharelato). Orientador.
2019/08 - 2022/02. Orientação. Sustainable use of microalgae for the tertiary treatment of urban wastewater.Post-Doc Researcher (Outra). Orientador.
2021/01 - 2021/12. Orientação. Establishment of microalgae as functional food with antioxidant and anti-inflammatory properties.Mestrado em Tecnologia dos Alimentos (Mestrado). Orientador.
2020/10 - 2021/12. Orientação. Tratamento Terciário de Águas Residuais Urbanas por Microalgas: Efeito do Tempo de Retenção Hidráulico e Suplementação com CO2.Mestrado em Ciclo Urbano da Água (Mestrado). Orientador.
2021/12. Apresentação oral de trabalho. Urban wastewater treatment with microalgae in a pilot-scale plant: nutrients recovery and pharmaceuticals removal. ALGAEUROPE 2020.
2021/11. Apresentação oral de trabalho. Valorização dos subprodutos do tratamento de águas residuais urbanas com microalgas. Encontro Nacional de Entidades Gestoras de Água e Saneamento.
2020 - 2021/09. Orientação. Otimização do Tratamento Terciário de Água Residuais através da utilização de Microalgas.Mestrado em Ciclo Urbano da Água (Mestrado). Coorientador.
2017/05 - 2021/06. Orientação. Improvement of microalgal biomass using physiological and genetic approaches.Ciências do Mar, da Terra e do Ambiente (Doutoramento). Coorientador.
2021/03. Apresentação oral de trabalho. Otimização do Tratamento Terciário de Águas Residuais através da Utilização de Microalgas. 15.º Congresso da Água.
2019 - 2021/02. Orientação. Bioactive compounds and antioxidant activity from Alaria esculenta cultivated on long-lines in Bantry Bay: effect of cultivation and processing method.Mestrado em Aquacultura e Pescas (Mestrado). Coorientador.
2019 - 2020/12. Orientação. Urban wastewater treatment using microalgal consortia.Mestrado em Biologia Molecular e Microbiana. Orientador.
2020/03 - 2020/09. Orientação. Tratamento de águas residuais terciárias por Chlorella sp. GTM05 isolada de efluentes urbanos.Biologia Marinha e Pescas (Licenciatura/Bacharelato). Coorientador.
2020/03 - 2020/09. Orientação. Microalgas no tratamento de águas residuais de aquacultura.Biologia Marinha e Pescas (Licenciatura/Bacharelato). Orientador.
2020/03 - 2020/09. Orientação. NUTRIENT REMOVAL AND BIOMASS PRODUCTION OF A MICROALGAL CONSORTIUM FOR WASTEWATER TREATMENT.Biologia Marinha e Pescas (Licenciatura/Bacharelato). Orientador.
2019 - 2020/05. Orientação. Searching for neuroprotective compounds from marine microalgae with application in Alzheimer's therapeutics.Mestrado Erasmus Mundus de Qualidade num Laboratório de Análises (Mestrado). Orientador.
2019/04 - 2019/12. Orientação. Síntese de piridazinas, pirazoles e triazoles com aplicação terapêutica na Doença d'Alzheimer.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Coorientador.
2019/04 - 2019/11. Orientação. Síntese de piridazinas, pirazoles e triazoles com atividade quelante.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Coorientador.
2017 - 2019/11/04. Orientação. Unravelling the biotechnological potential of halophyte species from the Algarve coast.Ciências do Mar, da Terra e do Ambiente (Doutoramento). Coorientador.
2018/10 - 2019/09. Orientação. Searching for innovative anti-tumoural drugs in marine microalgae.Mestrado Erasmus Mundus de Qualidade num Laboratório de Análises (Mestrado). Orientador.
2018/10 - 2019/09. Orientação. Development of extracts with cosmeceutical applications from marine microalgae.Mestrado Erasmus Mundus de Qualidade num Laboratório de Análises (Mestrado). Orientador.
2019/03 - 2019/07. Orientação. Nutritional and Functional Evaluation of Halophyte Plants.Bioquímica (Licenciatura/Bacharelato). Orientador.
2016 - 2019/07/17. Orientação. Biotechnological applications of a promising marine chlorophyte (Tetraselmis sp. CTP4): a biorefinery approach.Ciências do Mar, da Terra e do Ambiente (Doutoramento). Coorientador.
2015 - 2019/05/23. Orientação. Chemical and biological characterization of halophyte plants with ethnopharmacological use in the Algarve coast.Ciências do Mar, da Terra e do Ambiente (Doutoramento). Orientador.
2018/01 - 2019/03. Orientação. Optimization of the production of fucoxanthin-rich fractions from the microalga Isochrysis galbana.Mestrado em Biologia Marinha (Mestrado). Orientador.
2018/01 - 2019/03. Orientação. Optimization of Emiliania huxleyi growth for CO2 mitigation and production of n-3 polyunsaturated fatty acids.Mestrado em Biologia Molecular e Microbiana. (Mestrado). Coorientador.
2018/01 - 2018/09. Orientação. Evaluación nutricional y funcional de plantas halófitas del Parque Natural Bahía de Cádiz y Parque Natural Ría Formosa (Portugal): comparación con plantas cultivadas.Máster en Agroalimentación (Mestrado). Orientador.
2018/08/27. Apresentação oral de trabalho. Cultivation of Halophytes – Effect of Salinity on Nutritional and Functional Properties. ICFND 2018: 20th International Conference on Food, Nutrition and Dietetics.
2017 - Presente. Orientação. Unlocking the potential of halophyte plants from extreme maritime environments as sources of innovative products for use in veterinary parasitology.Ciências Agrárias e Ambientais (associação) (Doutoramento). Coorientador.
2016/10 - 2017/09. Orientação. Exploitation of Bioactive Molecules in the Processing of Microalgal Biomass into Biodiesel.Mestrado em Biologia Molecular e Microbiana (Mestrado). Coorientador.
2016/09 - 2017/07. Orientação. Optimization of carotenoid production by a stress-tolerant microalga Tetraselmis sp. CTP4.Master’s in Marine Sciences. (Mestrado). Coorientador.
2016/10 - 2017/06. Orientação. Microalgal bioactive compounds for the treatment of type-2 diabetes.Mestrado em Biologia Molecular e Microbiana (Mestrado). Coorientador.
2015/10 - 2016/12. Orientação. Production of Biofuels from Microalgal Biomass.Mestrado Integrado em Engenharia do Ambiente (Mestrado). Orientador.
2015/10 - 2016/12. Orientação. Evaluation of Cytotoxic Activity of Synthetic Bis-Indolyl Methanes: Structure-Activity Relationship.Mestrado Integrado em Ciências Farmacêuticas (Mestrado). Orientador.
2015/10 - 2016/09. Orientação. Purification and Characterization of Microalgae Lipids: a value-addition to Biodiesel Production.Mestrado Erasmus Mundus em Regulamentação e Inovação em Química (Mestrado). Orientador.
2015/03 - 2015/09. Orientação. Preliminary evaluation of chemical and physical properties of microalgal biodiesel.Biologia Marinha e Pescas (Licenciatura/Bacharelato). Orientador.
2014/09 - 2015/07. Orientação. Incorporation of Selenium on microalgae as suplement to Artemia and zebrafish.Mestrado em Aquacultura e Pescas (Mestrado). Orientador.
2013/10 - 2014/10. Orientação. Salt marsh plants as source of bioactive compounds.Mestrado em Ciências Biomédicas (Mestrado). Coorientador.
2013/10 - 2014/07. Orientação. Physiology and biochemistry of the effect of abiotic stress on the autochthonous CTP4 strain, a candidate microalga for biofuel production in Algarve.Mestrado em Biologia Marinha (Mestrado). Coorientador.
2013/10 - 2014/06. Orientação. Estudo do efeito da salinidade e concentração de ferro no crescimento e conteúdo lipídico da estirpe de microalga CTP4.Mestrado em Biologia Marinha (Mestrado). Coorientador.
2012 - 2013. Orientação. Biochemical characterization of antitumoral compounds present in selected halophytes.Post-Doc Researcher (Outra). Coorientador.
Projetos
Projetos
2010/01 - 2013/04. SEABIOMED - Marine photosynthetic organisms of the Algarve coast with biomedical applications. Investigador. Fundação para a Ciência e a Tecnologia.
2005 - 2007. BIOTA - Biomarkers in bivalves from hotspots of contamination in the algarvian coast. Investigador. Fundação para a Ciência e a Tecnologia.
1996 - 1999. Integration between physic-chemistry of interfaces, biochemistry and biology in evaluation of toxicological parameters. Investigador. Fundação para a Ciência e a Tecnologia.
1995 - 1999. Non-natural environmental changes in coastal ecosystems: effects and constraints. Investigador. Fundação para a Ciência e a Tecnologia.
2019/11 - 2022/06. Projeto 5279 - BLUE CROWDFUNDING, Espaço Mediterâneo. Investigador. Universidade do Algarve.
2021/01/01 - 2023/06/30. PERFORMALGAE - Estabelecimento de culturas industriais de algas de alto desempenho para a produção de bioestimulantes e alimentos funcionais, Sistema de Incentivos à Investigação e Desenvolvimento Tecnológico. Investigador. Universidade do Algarve.
2021/06/01 - 2025/05/31. ALGAE4IBD –FROM NATURE TO BEDSIDE- ALGAE BASED BIO COMPOUND FOR PREVENTION AND TREATMENT OF INFLAMMATION, PAIN AND IBD, Horizon 2020 Framework Programme (H2020). Bolseiro de Integração na Investigação. Centro de Ciências do Mar.
2019/10/01 - 2023/09/30. PROFUTURE: MICROALGAE PROTEIN INGREDIENTS FOR THE FOOD AND FEED OF THE FUTURE, H2020-EU.3.2.1.1. - Increasing production efficiency and coping with climate change, while ensuring. Investigador. ASSOCIAÇÃO OCEANO VERDE - LABORATÓRIO COLABORATIVO PARA O DESENVOLVIMENTO DE TECNOLOGIAS E PRODUTOS VERDES DO OCEANO.
2020/01 - 2023/06. ALLARVAE- Novas formulações de microalgas para larvicultura marinha.
2021/04 - 2023/04. Nutrisafe - Explorando um novo e sustentável suplemento alimentar de origem marinha na promoção da longevidade e qualidade de vida em tempos de pandemia.
2020/06 - 2023/03. ALGAESOLUTIONS - Solutions for algae industries to improve growth, induction of high value metabolites and early detection of contaminants.
2018/09/28 - 2022/05/31. An Integrated, Sustainable Process for the Tertiary Treatment of Urban Wastewater using Microalgae in the Algarve region, 9471 - RIDTI. Centro de Ciências do Mar; Rede de Química e Tecnologia Laboratório Associado para a Química Verde; Universidade do Algarve.
2020/10 - 2022/01. GreenDune.
2020/10 - 2022/01. ALGACYCLE - Valorisation of greenhouse effluents with microalgae: Sustainable aquafeeds and biostimulants from drain water.
2020/01 - 2022/01. ZEBRABLOOM - Development of microalgae commercial products for zebrafish nutrition.
2019/03 - 2022/01. ACCESS2SEA.
2019/01/01 - 2021/12/31. ALGAVALOR - MicroALGAs: produção integrada e VALORização da biomassa e das suas diversas aplicações, FEDER. Investigador. Universidade do Algarve.
2016/10/01 - 2020/03/31. XtremeGourmet – Plantas EXtremófilas na Cozinha Gourmet, FEDER. Investigador responsável. Universidade do Algarve Faculdade de Ciências e Tecnologia.
2017/06 - 2019/12. ALGARED+ - RED transfronteriza para el desarrollo de productos innovadores con microALGAs.
2016 - 2019. Blue Energy for the Mediterranean Sea, Blue Energy for the Mediterranean Sea. Investigador. Universidade do Algarve.
2013/05/01 - 2015/12/31. Halophytes: a precious resource of nutritional elements and bioactive compounds, 3599-PPCDT. Centro de Ciências do Mar; Fundação da Faculdade de Ciências da Universidade de Lisboa.
2012 - 2014. SABA-1 - Screening for lipid hyper-producers species in Saudi Arabia coastal waters for Biofuel production from micro-Algae.
2011/09 - 2013/08. SEAWEED AD – Anaerobic Digestion of Seaweed for Biofuels.
2010/01/01 - 2013/06/30. Regulation of iron homeostasis in cyanobacteria, 3599-PPCDT. Instituto de Biotecnologia e Bioengenharia; Universidade do Algarve; Albert-Ludwigs-Universität Freiburg Institut für Biologie III; Centro de Ciências do Mar.
1995/07/01 - 1996/09/30. EFEITO DE XENOBIÓTICOS EM POPULAÇÕES DE AMEIJOA DA RIA FORMOSA: PRODUÇÃO DE RADICAIS LIVRES DE OXIGÉNIO E DE ENZIMAS ANTIOXIDANTES, POCTI. Universidade de Santiago de Compostela; Universitat de Barcelona; Plymouth Marine Laboratory.
Produções
Davide Liberti; Paola Imbimbo; Enrica Giustino; Luigi D’Elia; Mélanie Silva; Luísa Barreira; Daria Maria Monti. 2023. "Shedding Light on the Hidden Benefit of Porphyridium cruentum Culture". Antioxidants. https://doi.org/10.3390/antiox12020337
Gabriel Bombo; Nathana L. Cristofoli; Tamára F. Santos; Lisa Schüler; Inês B. Maia; Hugo Pereira; Luísa Barreira; João Varela. 2023. "Dunaliella viridis TAV01: A Halotolerant, Protein-Rich Microalga from the Algarve Coast". Applied Sciences. https://doi.org/10.3390/app13042146
Etiele Greque de Morais; José Carlos Amaro Marques; Paulo Ricardo Cerqueira; Cláudia Dimas; Vânia Serrão Sousa; Nuno Gomes; Margarida Ribau Teixeira; et al. 2022. "Tertiary urban wastewater treatment with microalgae natural consortia in novel pilot photobioreactors". Journal of Cleaner Production. https://doi.org/10.1016/j.jclepro.2022.134521
Alexandre R. Lima; Nathana L. Cristofoli; Kyriakos Filippidis; Luísa Barreira; Margarida C. Vieira. 2022. "Shelf-life study of a Salicornia ramosissima vegetable salt: An alternative to kitchen salt". Journal of Food Process Engineering. https://doi.org/10.1111/jfpe.14154
Raúl Barros; Raposo, S; Etiele G. Morais; Brígida Rodrigues; Valdemira Lourenço Afonso; Pedro Gonçalves; José Marques; et al. 2022. "Biogas Production from Microalgal Biomass Produced in the Tertiary Treatment of Urban Wastewater: Assessment of Seasonal Variations". Energies. https://doi.org/10.3390/en15155713
Mélanie Silva; Farah Kamberovic; Sisay Tesema Uota; Ismael-Mohammed Kovan; Carla S. B. Viegas; Dina C. Simes; Katkam N. Gangadhar; João Varela; Luísa Barreira. 2022. "Microalgae as Potential Sources of Bioactive Compounds for Functional Foods and Pharmaceuticals". Applied Sciences, 12 (12): 5877-5877. https://doi.org/10.3390/app12125877
Mariagrazia Molfetta; Etiele G. Morais; Luisa Barreira; Giovanni Luigi Bruno; Francesco Porcelli; Eric Dugat-Bony; Pascal Bonnarme; Fabio Minervini. 2022. "Protein Sources Alternative to Meat: State of the Art and Involvement of Fermentation". Foods, 11 (14): 2065-2065. https://doi.org/10.3390/foods11142065
Leal, Joana F.; Guerreiro, Bruno; Amado, Patrícia S. M.; Fernandes, André L.; Barreira, Luísa; Paixão, José A.; Cristiano, Maria L. S.. 2021. "On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[d]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate". Molecules, 26 (6). https://doi.org/10.3390/molecules26061501
Schüler, Lisa M.; Bombo, Gabriel; Duarte, Paulo; Santos, Tamára F.; Maia, Inês B.; Pinheiro, Filipa; Marques, José; et al. 2021. "Carotenoid biosynthetic gene expression, pigment and n-3 fatty acid contents in carotenoid-rich Tetraselmis striata CTP4 strains under heat stress combined with high light". Bioresource Technology, 337. https://doi.org/10.1016/j.biortech.2021.125385
2021. Cultured Microalgae for the Food Industry. Elsevier. https://doi.org/10.1016/c2019-0-01245-9
Alexandre Ribeiro Lima; Florinda Gama; Viana Castañeda-Loaiza; Camila Costa; Lisa Maylin Schüler; Tamára Santos; Miguel Salazar; et al. 2021. "Nutritional and Functional Evaluation of <i>Inula crithmoides</i> and <i>Mesembryanthemum nodiflorum</i> Grown in Different Salinities for Human Consumption". Molecules. https://doi.org/10.3390/molecules26154543
Castañeda-Loaiza, V.; Oliveira, M.; Santos, T.; Schüler, L.; Lima, A.R.; Gama, F.; Salazar, M.; et al. 2020. "Wild vs cultivated halophytes: Nutritional and functional differences". Food Chemistry, 333. https://doi.org/10.1016/j.foodchem.2020.127536
Pereira, H.; Sardinha, M.; Santos, T.; Gouveia, L.; Barreira, L.; Dias, J.; Varela, J.. 2020. "Incorporation of defatted microalgal biomass (Tetraselmis sp. CTP4) at the expense of soybean meal as a feed ingredient for juvenile gilthead seabream (Sparus aurata)". Algal Research, 47. https://doi.org/10.1016/j.algal.2020.101869
Lima, A.R.; Castañeda-Loaiza, V.; Salazar, M.; Nunes, C.; Quintas, C.; Gama, F.; Pestana, M.; et al. 2020. "Influence of cultivation salinity in the nutritional composition, antioxidant capacity and microbial quality of Salicornia ramosissima commercially produced in soilless systems". Food Chemistry, 333. https://doi.org/10.1016/j.foodchem.2020.127525
Gómez-villegas, P.; Vigara, J.; Vila, M.; Varela, J.; Barreira, L.; Léon, R.. 2020. "Antioxidant, antimicrobial, and bioactive potential of two new haloarchaeal strains isolated from odiel salterns (Southwest Spain)". Biology, 9 (9): 1-20. https://doi.org/10.3390/biology9090298
Katkam N. Gangadhar; Maria João Rodrigues; Hugo Pereira; Helena Gaspar; F. Xavier Malcata; Luísa Barreira; João Varela. 2020. "Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea". Marine Drugs. https://doi.org/10.3390/md18110567
Lisa M. Schüler; Katkam N. Gangadhar; Paulo Duarte; Chloé Placines; Ana María Molina-Márquez; Rosa Léon-Bañares; Vânia S. Sousa; João Varela; Luísa Barreira. 2020. "Improvement of carotenoid extraction from a recently isolated, robust microalga, Tetraselmis sp. CTP4 (chlorophyta)". Bioprocess and Biosystems Engineering, 43 (5): 785-796. https://doi.org/10.1007/s00449-019-02273-9
Schüler, L.M.; Santos, T.; Pereira, H.; Duarte, P.; Katkam, N.G.; Florindo, C.; Schulze, P.S.C.; Barreira, L.; Varela, J.C.S.. 2020. "Improved production of lutein and ß-carotene by thermal and light intensity upshifts in the marine microalga Tetraselmis sp. CTP4". Algal Research, 45. https://doi.org/10.1016/j.algal.2019.101732
Baessa, M.; Rodrigues, M.J.; Pereira, C.; Santos, T.; da Rosa Neng, N.; Nogueira, J.M.F.; Barreira, L.; et al. 2019. "A comparative study of the in vitro enzyme inhibitory and antioxidant activities of Butea monosperma (Lam.) Taub. and Sesbania grandiflora (L.) Poiret from Pakistan: New sources of natural products for public health problems". South African Journal of Botany, 120: 146-156. https://doi.org/10.1016/j.sajb.2018.04.006
Trovão, M.; Pereira, H.; Silva, J.; Páramo, J.; Quelhas, P.; Santos, T.; Silva, J.T.; et al. 2019. "Growth performance, biochemical composition and sedimentation velocity of Tetraselmis sp. CTP4 under different salinities using low-cost lab- and pilot-scale systems". Heliyon, 5 (5). https://doi.org/10.1016/j.heliyon.2019.e01553
Cardoso, C.; Pereira, H.; Franca, J.; Matos, J.; Monteiro, I.; Pousão-Ferreira, P.; Gomes, A.; et al. 2019. "Lipid composition and some bioactivities of 3 newly isolated microalgae (Tetraselmis sp. IMP3, Tetraselmis sp. CTP4, and Skeletonema sp.)". Aquaculture International. https://doi.org/10.1007/s10499-019-00489-w
Pereira, H.; Silva, J.; Santos, T.; Gangadhar, K.N.; Raposo, A.; Nunes, C.; Coimbra, M.A.; et al. 2019. "Nutritional potential and toxicological evaluation of Tetraselmis sp. CtP4 microalgal biomass produced in industrial photobioreactors". Molecules, 24 (17). https://doi.org/10.3390/molecules24173192
Catarina Guerreiro Pereira; Luísa Barreira; Sebastiaan Bijttebier; Luc Pieters; Cátia Marques; Tamára F. Santos; Maria João Rodrigues; João Varela; Luísa Custódio. 2018. "Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp. maritima: from traditional remedies to prospective products". Scientific Reports, 8 (1). https://doi.org/10.1038/s41598-018-23038-6
Hugo Pereira; Peter S.C. Schulze; Lisa Maylin Schüler; Tamára Santos; Luísa Barreira; João Varela. 2018. "Fluorescence activated cell-sorting principles and applications in microalgal biotechnology". Algal Research, 30: 113-120. https://doi.org/10.1016/j.algal.2017.12.013
Christina C Roggatz; Mercedes González-Wangüemert; Hugo Pereira; Catarina Vizetto-Duarte; Maria João Rodrigues; Luísa Barreira; Manuela Moreira da Silva; João Varela; Luísa Custódio. 2018. "A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain)". Natural Product Research, 32 (1): 116-120. https://doi.org/10.1080/14786419.2017.1331224
Pereira, Hugo; Páramo, Jaime; Silva, Joana; Marques, Ana; Barros, Ana; Maurício, Dinis; Santos, Tamára; et al. 2018. Scale-up and large-scale production of Tetraselmis sp CTP4 (Chlorophyta) for CO2 mitigation: from an agar plate to 100-m(3) industrial photobioreactors. ABSTRACT: Industrial production of novel microalgal isolates is key to improving the current portfolio of available strains that are able to grow in large-scale production systems for different biotechnological applications, including carbon mitigation. In this context, Tetraselmis sp. CTP4 was successfully scaled up from an agar plate to 35-and 100-m(3) industrial scale tubular photobioreactors (. https://doi.org/10.1038/s41598-018-23340-3
González-Wangüemert, M.; Roggatz, C.C.; Rodrigues, M.J.; Barreira, L.; da Silva, M.M.; Custódio, L.. 2018. "A new insight into the influence of habitat on the biochemical properties of three commercial sea cucumber species". International Aquatic Research, 10 (4): 361-373. https://doi.org/10.1007/s40071-018-0210-9
Rodrigues, M.J.; Vizetto-Duarte, C.; Gangadhar, K.N.; Zengin, G.; Mollica, A.; Varela, J.; Barreira, L.; Custódio, L.. 2018. "In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells". Pharmacological Reports, 70 (5): 896-899. https://doi.org/10.1016/j.pharep.2018.02.001
Bruno de Sousa, C.; Lago, J.H.G.; Macridachis, J.; Oliveira, M.; Brito, L.; Vizetto-Duarte, C.; Florindo, C.; et al. 2018. "Report of in vitro antileishmanial properties of Iberian macroalgae". Natural Product Research, 1-5. https://doi.org/10.1080/14786419.2018.1434637
Cabral, L.I.L.; Brás, E.M.; Henriques, M.S.C.; Marques, C.; Frija, L.M.T.; Barreira, L.; Paixão, J.A.; Fausto, R.; Cristiano, M.L.S.. 2018. "Synthesis, Structure, and Cytotoxicity of a New Sulphanyl-Bridged Thiadiazolyl-Saccharinate Conjugate: The Relevance of S···N Interaction". Chemistry - A European Journal, 24 (13): 3251-3262. https://doi.org/10.1002/chem.201705319
Rodrigues, M.J.; Slusarczyk, S.; Pecio, L.; Matkowski, A.; Salmas, R.E.; Durdagi, S.; Pereira, C.; et al. 2018. "In vitro and in silico approaches to appraise Polygonum maritimum L. as a source of innovative products with anti-ageing potential". Industrial Crops and Products, 111: 391-399. https://doi.org/10.1016/j.indcrop.2017.10.046
Tiago Braga; Maria João Rodrigues; Hugo Pereira; João Varela; Luísa Barreira; Mercedes González-Wangüemert; Luísa Custódio. 2017. "Bursatella leachii from Mar Menor as a Source of Bioactive Molecules: Preliminary Evaluation of the Nutritional Profile, In Vitro Biological Activities, and Fatty Acids Contents". Journal of Aquatic Food Product Technology, 1-14. https://doi.org/10.1080/10498850.2017.1392670
Schulze, P.S.C.; Carvalho, C.F.M.; Pereira, H.; Gangadhar, K.N.; Schüler, L.M.; Santos, T.F.; Varela, J.C.S.; Barreira, L.. 2017. "Urban wastewater treatment by Tetraselmis sp. CTP4 (Chlorophyta)". Bioresource Technology, 223: 175-183. https://doi.org/10.1016/j.biortech.2016.10.027
Barreira, L.; Resek, E.; Rodrigues, M.J.; Rocha, M.I.; Pereira, H.; Bandarra, N.; da Silva, M.M.; Varela, J.; Custódio, L.. 2017. "Halophytes: Gourmet food with nutritional health benefits?". Journal of Food Composition and Analysis, 59: 35-42. https://doi.org/10.1016/j.jfca.2017.02.003
Bruno de Sousa, C.; Gangadhar, K.N.; Morais, T.R.; Conserva, G.A.A.; Vizetto-Duarte, C.; Pereira, H.; Laurenti, M.D.; et al. 2017. "Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata". Experimental Parasitology, 174: 1-9. https://doi.org/10.1016/j.exppara.2017.01.002
Grosso, C.; Cardoso, A.L.; Rodrigues, M.J.; Marques, C.; Barreira, L.; Lemos, A.; Pinho e Melo, T.M.D.V.. 2017. "Hetero-Diels-Alder approach to Bis(indolyl)methanes". Bioorganic and Medicinal Chemistry, 25 (3): 1122-1131. https://doi.org/10.1016/j.bmc.2016.12.028
Rodrigues, M.J.; Custódio, L.; Lopes, A.; Oliveira, M.; Neng, N.R.; Nogueira, J.M.; Martins, A.; et al. 2017. "Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum". Pharmaceutical biology, 55 (1): 1348-1357. https://doi.org/10.1080/13880209.2017.1301493
Pereira, C.G.; Barreira, L.; da Rosa Neng, N.; Nogueira, J.M.F.; Marques, C.; Santos, T.F.; Varela, J.; Custódio, L.. 2017. "Searching for new sources of innovative products for the food industry within halophyte aromatic plants: In vitro antioxidant activity and phenolic and mineral contents of infusions and decoctions of Crithmum maritimum L". Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2017.04.018
Rodrigues, M.J.; Gangadhar, K.N.; Zengin, G.; Mollica, A.; Varela, J.; Barreira, L.; Custódio, L.. 2017. "Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies". Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2017.04.006
Rocha, M.I.; Rodrigues, M.J.; Pereira, C.; Pereira, H.; da Silva, M.M.; da Neng, N.R.; Nogueira, J.M.F.; et al. 2017. "Biochemical profile and in vitro neuroprotective properties of Carpobrotus edulis L., a medicinal and edible halophyte native to the coast of South Africa". South African Journal of Botany, 111: 222-231. https://doi.org/10.1016/j.sajb.2017.03.036
Lopes, S.M.M.; Sousa, E.P.; Barreira, L.; Marques, C.; Rodrigues, M.J.; Pinho e Melo, T.M.V.D.. 2017. "Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5-a]pyridine-fused steroids". Steroids, 122: 16-23. https://doi.org/10.1016/j.steroids.2017.03.006
Oliveira, M.; João Rodrigues, M.; Pereira, C.; Neto, R.L.D.M.; Junior, P.A.S.; Neng, N.D.R.; Nogueira, J.M.F.; et al. 2017. "First report of the in vitro antileishmanial properties of extremophile plants from the Algarve Coast". Natural Product Research, 1-5. https://doi.org/10.1080/14786419.2017.1326489
Pereira, C.G.; Barreira, L.; Bijttebier, S.; Pieters, L.; Neves, V.; Rodrigues, M.J.; Rivas, R.; Varela, J.; Custódio, L.. 2017. "Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea (Camellia sinensis) and rooibos tisane (Aspalathus linearis)". Journal of Pharmaceutical and Biomedical Analysis, 145: 593-603. https://doi.org/10.1016/j.jpba.2017.07.007
Pereira, C.G.; Custódio, L.; Rodrigues, M.J.; Neng, N.R.; Nogueira, J.M.F.; Carlier, J.; Costa, M.C.; Varela, J.; Barreira, L.. 2017. "Profiling of antioxidant potential and phytoconstituents of Plantago coronopus | Avaliação do potencial antioxidante e perfil fitoquímico do Plantago coronopus". Brazilian Journal of Biology, 77 (3): 632-641. https://doi.org/10.1590/1519-6984.02416
Schüler, L.M.; Schulze, P.S.C.; Pereira, H.; Barreira, L.; León, R.; Varela, J.. 2017. "Trends and strategies to enhance triacylglycerols and high-value compounds in microalgae". Algal Research, 25: 263-273. https://doi.org/10.1016/j.algal.2017.05.025
Rodrigues, M.J.; Oliveira, M.; Neves, V.; Ovelheiro, A.; Pereira, C.A.; Neng, N.R.; Nogueira, J.M.F.; et al. 2017. "Coupling sea lavender (Limonium algarvense Erben) and green tea (Camellia sinensis (L.) Kuntze) to produce an innovative herbal beverage with enhanced enzymatic inhibitory properties". South African Journal of Botany. https://doi.org/10.1016/j.sajb.2017.12.003
Custódio, L.; Silvestre, L.; Rocha, M.I.; Rodrigues, M.J.; Vizetto-Duarte, C.; Pereira, H.; Barreira, L.; et al. 2016. "Methanol extracts from Cystoseira tamariscifolia and Cystoseira nodicaulis are able to inhibit cholinesterases and protect a human dopaminergic cell line from hydrogen peroxide-induced cytotoxicity". Pharmaceutical Biology, 54 (9): 1687-1696. https://doi.org/10.3109/13880209.2015.1123278
Pereira, H.; Gangadhar, K.N.; Schulze, P.S.C.; Santos, T.; De Sousa, C.B.; Schueler, L.M.; Custódio, L.; et al. 2016. "Isolation of a euryhaline microalgal strain, Tetraselmis sp. CTP4, as a robust feedstock for biodiesel production". Scientific Reports, 6. https://doi.org/10.1038/srep35663
A. Ismael; M. S. C. Henriques; C. Marques; M. Rodrigues; L. Barreira; J. A. Paixão; R. Fausto; et al. 2016. "Exploring saccharinate-tetrazoles as selective Cu(ii) ligands: structure, magnetic properties and cytotoxicity of copper(ii) complexes based on 5-(3-aminosaccharyl)-tetrazoles". RSC Advances, 6 (75): 71628-71637. https://doi.org/10.1039/C6RA15051A
Vizetto-Duarte, C.; Custódio, L.; Acosta, G.; Lago, J.H.G.; Morais, T.R.; De Sousa, C.B.; Gangadhar, K.N.; et al. 2016. "Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds". PeerJ, 2016 (2). https://doi.org/10.7717/peerj.1704
Custódio, L.; Laukaityte, S.; Engelen, A.H.; Rodrigues, M.J.; Pereira, H.; Vizetto-Duarte, C.; Barreira, L.; et al. 2016. "A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal". Natural Product Research, 30 (6): 724-728. https://doi.org/10.1080/14786419.2015.1040791
Schulze, Peter S.C.; Pereira, Hugo; Schueler, Lisa; Guerra, Rui Manuel Farinha das Neves; Barreira, Luísa; Perales, Jose A.; Varela, João; et al. 2016. Effect of light quality supplied by light emitting diodes (LEDs) on growth and biochemical profiles of Nannochloropsis oculata and Tetraselmis chuii. Biochemical components obtained by microalgal biomass can be induced by specific wavelengths and processed to high value food/feed supplements or pharma- and nutraceuticals. Two biotechnologically relevant microalgae, Nannochloropsis oculata and Tetraselmis chuii, were exposed to non-tailored LEDs light sources emitting either mono- or multichromatic light with low red but significant blue (<450 n. https://doi.org/10.1016/j.algal.2016.03.034
Vizetto-Duarte, Catarina; Custódio, Luísa; Barreira, Luísa; da Silva, Manuela Moreira; Rauter, Amelia P.; Albericio, Fernando; Varela, J.; et al. 2016. Proximate biochemical composition and mineral content of edible species from the genus Cystoseira in Portugal. Macroalgae are valuable resources for human consumption in many countries. This work reports for the first time a comparative evaluation of the nutritional properties of five edible macroalgae from the genus Cystoseira, namely C. humilis, C. tamariscifolia, C. nodicaulis, C. compressa and C. baccata. For this purpose, their proximate composition was determined in terms of moisture, ash, and total . https://doi.org/10.1515/bot-2016-0014
Faculdade de Engenharia; Gangadhar, K.N.; Pereira, H.; Rodrigues, M.J.; Custódio, L.; Barreira, L.; Malcata, F.X.; Varela, J.. 2016. Microalgae-based unsaponifiable matter as source of natural antioxidants and metal chelators to enhance the value of wet Tetraselmis chuii biomass. The present work aimed to determine the antioxidant, metal chelating and neuroprotective potential of the unsaponifiable matter (UM) of Tetraselmis chuii to be applied to a biorefinery setting. The UM obtained via saponification from crude lipids extracted from microalgal wet biomass showed a radical scavenging activity (RSA) towards the DPPH radical of 90.7±1.3% and 57.1±1.2% at a concentration o. https://doi.org/10.1515/chem-2016-0029
Pereira, C. G.; Custódio, Luísa; Rodrigues, M. J.; Neng, N. R.; Nogueira, J. M. F.; Carlier, J.; Costa, Maria Clara; Varela, J.; Barreira, Luísa. 2016. Profiling of antioxidant potential and phytoconstituents of Plantago coronopus. The halophyte species Plantago coronopus has several described ethnomedicinal uses, but few reported biological activities. This work carried out for the first time a comparative analysis of P. coronopus organs in terms of phenolic composition and antioxidant activity of organic and water extracts from roots, leaves and flowers. The leaves contents in selected nutrients, namely amino acids and min. https://doi.org/10.1590/1519-6984.02416
Vizetto-Duarte, Catarina; Custódio, Luísa; Gangadhar, KatkamN.; Lago, João Henrique G.; Dias, Catarina; Matos, Ana Marta; Neng, Nuno; et al. 2016. Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage. Background: Brown macroalgae have attracted attention because they display a wide range of biological activities, including antitumoral properties. In this study we isolated isololiolide from Cystoseira tamariscifolia for the first time.Purpose: To examine the therapeutical potential of isololiolide against tumor cell lines.Methods/Study design: The structure of the compound was established and co. https://doi.org/10.1016/j.phymed.2016.02.008
Roggatz, C.C.; González-Wangüemert, M.; Pereira, H.; Rodrigues, M.J.; da Silva, M.M.; Barreira, L.; Varela, J.; Custódio, L.. 2016. "First report of the nutritional profile and antioxidant potential of Holothuria arguinensis, a new resource for aquaculture in Europe". Natural Product Research, 30 (18): 2034-2040. https://doi.org/10.1080/14786419.2015.1107555
Gangadhar, K.N.; Pereira, H.; Diogo, H.P.; Borges dos Santos, R.M.; Prabhavathi Devi, B.L.A.; Prasad, R.B.N.; Custódio, L.; et al. 2016. "Assessment and comparison of the properties of biodiesel synthesized from three different types of wet microalgal biomass". Journal of Applied Phycology, 28 (3): 1571-1578. https://doi.org/10.1007/s10811-015-0683-5
Lopes, A.; Rodrigues, M.J.; Pereira, C.; Oliveira, M.; Barreira, L.; Varela, J.; Trampetti, F.; Custódio, L.. 2016. "Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants". Industrial Crops and Products, 94: 299-307. https://doi.org/10.1016/j.indcrop.2016.08.040
Oliveira, M.; Barreira, L.; Gangadhar, K.N.; Rodrigues, M.J.; Santos, T.; Varela, J.; Custódio, L.. 2016. "Natural products from marine invertebrates against Leishmania parasites: a comprehensive review". Phytochemistry Reviews, 15 (4): 663-697. https://doi.org/10.1007/s11101-016-9455-3
Oliveira, M.; Sales Junior, P.A.; Rodrigues, M.J.; DellaGreca, M.; Barreira, L.; Murta, S.M.F.; Romanha, A.J.; Custódio, L.. 2016. "Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal". Asian Pacific Journal of Tropical Medicine, 9 (8): 735-741. https://doi.org/10.1016/j.apjtm.2016.06.015
Rodrigues, M.J.; Neves, V.; Martins, A.; Rauter, A.P.; Neng, N.R.; Nogueira, J.M.F.; Varela, J.; Barreira, L.; Custódio, L.. 2016. "In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis)". Food Chemistry, 200: 322-329. https://doi.org/10.1016/j.foodchem.2016.01.048
Grosso, C.; Cardoso, A.L.; Lemos, A.; Varela, J.; Rodrigues, M.J.; Custódio, L.; Barreira, L.; Pinho E Melo, T.M.V.D.. 2015. "Novel approach to bis(indolyl)methanes: De novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties". European Journal of Medicinal Chemistry, 93: 9-15. https://doi.org/10.1016/j.ejmech.2015.01.050
Rodrigues, M.J.; Soszynski, A.; Martins, A.; Rauter, A.P.; Neng, N.R.; Nogueira, J.M.F.; Varela, J.; Barreira, L.; Custódio, L.. 2015. "Unravelling the antioxidant potential and the phenolic composition of different anatomical organs of the marine halophyte Limonium algarvense". Industrial Crops and Products, 77: 315-322. https://doi.org/10.1016/j.indcrop.2015.08.061
Pereira, H.; Custódio, L.; Rodrigues, M.J.; De Sousa, C.B.; Oliveira, M.; Barreira, L.; Neng, N.D.R.; et al. 2015. "Biological activities and chemical composition of methanolic extracts of selected autochthonous microalgae strains from the Red Sea". Marine Drugs, 13 (6): 3531-3549. https://doi.org/10.3390/md13063531
Vizetto-Duarte, C.; Pereira, H.; De Sousa, C.B.; Rauter, A.P.; Albericio, F.; Custódio, L.; Barreira, L.; Varela, J.. 2015. "Fatty acid profile of different species of algae of the Cystoseira genus: A nutraceutical perspective". Natural Product Research, 29 (13): 1264-1270. https://doi.org/10.1080/14786419.2014.992343
Barreira, L.; Pereira, H.; Gangadhar, K.N.; Custódio, L.; Varela, J.. 2015. Medicinal Effects of Microalgae-Derived Fatty Acids. https://doi.org/10.1016/B978-0-12-800776-1.00013-3
Schulze, P.S.C.; Barreira, L.A.; Pereira, H.G.C.; Perales, J.A.; Varela, J.C.S.. 2014. "Light emitting diodes (LEDs) applied to microalgal production". Trends in Biotechnology, 32 (8): 422-430. https://doi.org/10.1016/j.tibtech.2014.06.001
Rodrigues, M.J.; Gangadhar, K.N.; Vizetto-Duarte, C.; Wubshet, S.G.; Nyberg, N.T.; Barreira, L.; Varela, J.; Custódio, L.. 2014. "Maritime halophyte species from southern Portugal as sources of bioactive molecules". Marine Drugs, 12 (4): 2228-2244. https://doi.org/10.3390/md12042228
Custódio, L.; Soares, F.; Pereira, H.; Barreira, L.; Vizetto-Duarte, C.; Rodrigues, M.J.; Rauter, A.P.; Alberício, F.; Varela, J.. 2014. "Fatty acid composition and biological activities of Isochrysis galbana T-ISO, Tetraselmis sp. and Scenedesmus sp.: Possible application in the pharmaceutical and functional food industries". Journal of Applied Phycology, 26 (1): 151-161. https://doi.org/10.1007/s10811-013-0098-0
Custódio, L.; Soares, F.; Pereira, H.; Rodrigues, M.J.; Barreira, L.; Rauter, A.P.; Alberício, F.; Varela, J.. 2014. "Botryococcus braunii and Nannochloropsis oculata extracts inhibit cholinesterases and protect human dopaminergic SH-SY5Y cells from H<inf>2</inf>O<inf>2</inf>-induced cytotoxicity". Journal of Applied Phycology. https://doi.org/10.1007/s10811-014-0369-4
Barreira, Luísa. 2013. "Assessment of oil contamination in the bay of Porto Grande (Cape Verde) using the mullet Chelon bispinosus". African Journal of Environmental Science and Technology. https://doi.org/10.5897/AJEST2013.
Cravo, A.; Lopes, B.; Serafim, A.; Company, R.; Barreira, L.; Gomes, T.; Bebianno, M.J.. 2013. "Spatial and seasonal biomarker responses in the clam Ruditapes decussatus". Biomarkers, 18 (1): 30-43. https://doi.org/10.3109/1354750X.2012.730549
Martins, D.A.; Custódio, L.; Barreira, L.; Pereira, H.; Ben-Hamadou, R.; Varela, J.; Abu-Salah, K.M.. 2013. "Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae". Marine Drugs, 11 (7): 2259-2281. https://doi.org/10.3390/md11072259
Maria, V.L.; Gomes, T.; Barreira, L.; Bebianno, M.J.. 2013. "Impact of benzo(a)pyrene, Cu and their mixture on the proteomic response of Mytilus galloprovincialis". Aquatic Toxicology, 144-145: 284-295. https://doi.org/10.1016/j.aquatox.2013.10.009
Pereira, H.; Barreira, L.; Custódio, L.; Alrokayan, S.; Mouffouk, F.; Varela, J.; Abu-Salah, K.M.; Ben-Hamadou, R.. 2013. "Isolation and fatty acid profile of selected microalgae strains from the red sea for biofuel production". Energies, 6 (6): 2773-2783. https://doi.org/10.3390/en6062773
Varela, J.; Vizetto-Duarte, C.; Custódio, L.; Barreira, L.; Albericio, F.. 2013. "Marine Peptides and Proteins with Cytotoxic and Antitumoral Properties". Em Energies. https://doi.org/10.1002/9781118375082.ch19
Pereira, H.; Amaro, H.M.; Katkam, N.G.; Barreira, L.; Catarina Guedes, A.; Varela, J.; Malcata, F.X.. 2013. "Microalgal Biodiesel". Em Energies. https://doi.org/10.1002/9781118523360.ch17
Custódio, L.; Ferreira, A.C.; Pereira, H.; Silvestre, L.; Vizetto-Duarte, C.; Barreira, L.; Rauter, A.P.; Alberício, F.; Varela, J.. 2012. "The marine halophytes Carpobrotus edulis L. and Arthrocnemum macrostachyum L. are potential sources of nutritionally important PUFAs and metabolites with antioxidant, metal chelating and anticholinesterase inhibitory activities". Botanica Marina, 55 (3): 281-288. https://doi.org/10.1515/bot-2012-0098
Hernández-Prieto, M.A.; Schön, V.; Georg, J.; Barreira, L.; Varela, J.; Hess, W.R.; Futschik, M.E.. 2012. "Iron deprivation in synechocystis: Inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling". G3: Genes, Genomes, Genetics, 2 (12): 1475-1495. https://doi.org/10.1534/g3.112.003863
Custódio, L.; Justo, T.; Silvestre, L.; Barradas, A.; Duarte, C.V.; Pereira, H.; Barreira, L.; et al. 2012. "Microalgae of different phyla display antioxidant, metal chelating and acetylcholinesterase inhibitory activities". Food Chemistry, 131 (1): 134-140. https://doi.org/10.1016/j.foodchem.2011.08.047
Pereira, H.; Barreira, L.; Figueiredo, F.; Custódio, L.; Vizetto-Duarte, C.; Polo, C.; Rešek, E.; et al. 2012. "Polyunsaturated fatty acids of marine macroalgae: Potential for nutritional and pharmaceutical applications". Marine Drugs, 10 (9): 1920-1935. https://doi.org/10.3390/md10091920
Pereira, Hugo; Barreira, Luísa Paula Viola Afonso; Mozes, Andre; Florindo, C.; Polo, Cristina; Duarte, Catarina V.; Custódio, Luísa Margarida Batista; et al. 2011. "Microalgal Systems for Wastewater Treatment: Technological Trends and Challenges towards Waste Recovery". Energies, 4. https://doi.org/10.1186/1754-6834-4-61
Cravo, A.; Lopes, B.; Serafim, A.; Company, R.; Barreira, L.; Gomes, T.; Bebianno, M.J.. 2009. "A multibiomarker approach in Mytilus galloprovincialis to assess environmental quality". Journal of Environmental Monitoring, 11 (9): 1673-1686. https://doi.org/10.1039/b909846a
Bebianno, M.J.; Barreira, L.A.. 2009. "Polycyclic aromatic hydrocarbons concentrations and biomarker responses in the clam Ruditapes decussatus transplanted in the Ria Formosa lagoon". Ecotoxicology and Environmental Safety, 72 (7): 1849-1860. https://doi.org/10.1016/j.ecoenv.2009.03.016
Barreira, L.A.; Mudge, S.M.; Bebianno, M.J.. 2007. "Oxidative stress in the clam Ruditapes decussatus (Linnaeus, 1758) in relation to polycyclic aromatic hydrocarbon body burden". Environmental Toxicology, 22 (2): 203-221. https://doi.org/10.1002/tox.20257
Barreira, L.A.; Mudge, S.M.; Bebianno, M.J.. 2007. "Polycyclic aromatic hydrocarbons in clams Ruditapes decussatus (Linnaeus, 1758)". Journal of Environmental Monitoring, 9 (2): 187-198. https://doi.org/10.1039/b614919g
Barreira, L.A.; Mudge, S.M.; Bebianno, M.J.. 2007. "Concentration and sources of polycyclic aromatic hydrocarbons in sediments from the Ria Formosa Lagoon". Environmental Forensics, 8 (3): 231-243. https://doi.org/10.1080/15275920701506359
Barreira, Luísa Paula Viola Afonso. 2007. "Polycyclic aromatic hydrocarbons and oxidative stress markers in the clam Ruditapes decussatus from the Ria Formosa (Portugal)". Doutoramento. http://hdl.handle.net/10400.1/692
Barreira, L.A.; Bebianno, M.J.; Mudge, S.M.; Ferreira, A.M.; Albino, C.I.; Veriato, L.M.. 2005. "Relationship between PCBs in suspended and settled sediments from a coastal lagoon | Relación entre PCBs en sedimentos suspendidos y depositados de una laguna costera". Ciencias Marinas, 31 (1 B): 179-195. https://doi.org/10.7773/cm.v31i12.97
Geret, F.; Serafim, A.; Barreira, L.; Bebianno, M.J.. 2002. "Effect of cadmium on antioxidant enzyme activities and lipid peroxidation in the gills of the clam Ruditapes decussatus". Biomarkers, 7 (3): 242-256. https://doi.org/10.1080/13547500210125040
Geret, F.; Serafim, A.; Barreira, L.; João Bebianno, M.. 2002. "Response of antioxidant systems to copper in the gills of the clam Ruditapes decussatus". Marine Environmental Research, 54 (3-5): 413-417. https://doi.org/10.1016/S0141-1136(02)00164-2
Mudge, S.M.; Bebianno, M.J.A.F.; East, J.A.; Barreira, L.A.. 1999. "Sterols in the Ria Formosa lagoon, Portugal". Water Research, 33 (4): 1038-1048. https://doi.org/10.1016/S0043-1354(98)00283-8
Mudge, S.M.; East, J.A.; Bebianno, M.J.; Barreira, L.A.. 1998. "Fatty acids in the Ria Formosa Lagoon, Portugal". Organic Geochemistry, 29 (4): 963-977. https://doi.org/10.1016/S0146-6380(98)00049-7
Mira, L.; Maia, L.; Barreira, L.; Manso, C.F.. 1995. "Evidence for Free Radical Generation Due to NADH Oxidation by Aldehyde Oxidase During Ethanol Metabolism". Archives of Biochemistry and Biophysics, 318 (1): 53-58. https://doi.org/10.1006/abbi.1995.1203
