Silhueta de pessoa indiferenciada
Centro de Ciências do Mar
Unidade ID
Centro de Ciências do Mar
Leonor Cancela (LC) is Full Professor (retired since sept 2025) at the Faculty of Medicine and Biomedical Sciences of the University of Algarve/UALG, Emeritus Full Professor (awarded in February 2026), member of the Algarve Biomedical Centre and founding member of the Centre for Marine Sciences-CCMAR where she remains active. She developed her undergraduate/graduate studies at University Paris VI- Pierre et Marie Curie and her PhD work at INSERM/ Hospital Lariboisière, in Paris. She was hired as a postdoctoral researcher by the Univ. of California between Jan 1986-Jan 1988 at UC Riverside and between Feb1988- Nov1992 at UC San Diego. She obtained a position at UALG in Dec1992 and became full professor in 2006. LC is member since 1993 of the Portuguese Biochemical Society and was elected its President between 2005-2008 (2x 2yr mandate). She is member of the board of the Portuguese Society of Genetics since 2010, elected as President in January 2020 to February 2026. She served as Director of the PhD program (2008-2025/08) and the Bachelor (2006-2024/08) in Biomedical Science at UAlg, Director of the UAlg Doctoral College (2019-2025/08) and President of the Scientific Council of the Department, now Faculty, of Medicine and Biomedical Sciences (2019-2025/08). She implemented the BIOSKEL research laboratory that she leads since 1994 (https://ccmar.ualg.pt/group/comparative-adaptive-and-functional-skeletal-biology) and has coordinated over 150 undergraduate, PhDs and postdoctoral fellows, published over 200 articles in international refereed journals, 15 book chapters, and 7 patents. She is co-founder of Technozeb, a Business Unit of Technophage SA involved in the discovery of molecules with therapeutic interest using zebrafish. She created the Lab-it (Itinerant Laboratory of Molecular Genetics) in 2008 at the UALG and remains its coordinator to present (https://www.ualg.pt/en/lab-it-itinerant-laboratory). LC is regularly invited to give seminars and integrate juris and evaluation panels in national/international institutions and agencies, including chair of ERC committees and sessions at national and international congresses. Research interests focus in molecular, environmental and epigenetic determinants of skeletogenesis in health and disease and the use of zebrafish as model for human pathologies.

Atividades

Atividades
2020/03/01 - Presente. Orientação. IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS.Biomedical Sciences (Doutoramento). Coorientador.
2019/03/01 - Presente. Orientação. Epigenetic regulation of ZNF687 in bone cells: elucidation of its role in the progression of Paget’s disease towards giant cell tumor of bone.Biomedical Sciences (Doutoramento). Coorientador.
2019/01 - Presente. Orientação. Effect of marine derived extract on osteogenesis and mineralogenesis.Biomedical Sciences (Doutoramento). Coorientador.
2019/01 - Presente. Orientação. Effects of anti- and pro-oxidants in bone mineralization and remodelling.Biomedical Sciences (Doutoramento). Coorientador.
2017/10 - Presente. Orientação. How microplastics and adsorbed pollutants affect zebrafish development?.PhD Program in Marine, Earth and Environmental Sciences, (Doutoramento). Coorientador.
2017 - Presente. Orientação. Molecular basis for the epigenetic regulation of MGP in cancer.Ciencias Biomédicas (Doutoramento). Coorientador.
Membro de associação. European Calcified Tissue Society. member.
Membro de associação. Sociedade Portuguesa de Bioquimica-Member(ongoing). Presidente elect 2005-2008. President of the General Assembly2009-2010. Member.
Membro de associação. President of the Portuguese Society of Genetics, elected in January 2020 for 2 year period. Re-elected for a second 2yr term until January 2024. President.
2021 - 2025. Membro de comissão. Presidente do Conselho Cientifico . Presidente / Vice-presidente. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2020/02 - 2025/01. Membro de comissão. Presidente da Socidade Portuguesa de Genética / President of the Portuguese Society of Genetics . Presidente / Vice-presidente. Sociedade Portuguesa de Genética.
2019 - 2025. Membro de comissão. Director of the Doctoral College, University of Algarve, by appointment of the rector. Diretor. Universidade do Algarve.
2006 - 2025. Membro de comissão. Director of the Bachelor degree (Licenciatura) in Biomedical Sciences. Diretor. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2022/01/24. Júri de grau académico. PhD em Ciências Biomédicas, especialidade de Neurociências, Faculdade Medicina da Universidade de Lisboa, . Arguente principal. Catarina Miranda Lourenço, (Doutoramento). Universidade de Lisboa Faculdade de Medicina.
2022/01/14. Júri de grau académico. Provas de Agregação em ECOLOGIA HUMANA E ADAPTAÇÃO. Arguente principal. Cristina Maria Proença Padez (Agregação). Universidade de Coimbra Faculdade de Ciencias e Tecnologia.
2019/01 - 2022/12. Comissão de avaliação. Convite para integrar painel de avaliação dos relatorios finais de projectos da FCT 2019-2022, area da Biologia Experimental e Bioquimica. Fundação para a Ciência e a Tecnologia. Fundação para a Ciência e a Tecnologia.
2022/01 - 2022/07. Comissão de avaliação. A3ES: convite para avaliar novos cursos, área da biotecnologia.
2021/12 - 2022/05. Membro de comissão. procedimento concursal internacional para professor catedrático na Faculdade de Ciências e Tecnologia referência: P053-21-11331, area das ciencias da vida. Edital_1480_2021. Membro. Universidade de Coimbra.
2021/12 - 2022/01/04. Comissão de avaliação. Evaluation of postdoctoral fellowships- PARIS REGION FELLOWSHIP PROGRAMME. Paris Region FP. European Commission Marie Sklodowska-Curie Actions.
2021/06 - 2022/05. Arbitragem científica em conferência. Meeting of the European Calcified Tissue Society. Helsinquia 2022. ECTS.
2021/01/14. Júri de grau académico. Provas de Agregação em Ciencias Biomédicas- Celulas Estaminais. Vogal. José Eduardo Marques Bragança (Agregação). Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/11/05 - 2022/02/28. Comissão de avaliação. Invitation to participate in evaluation of the proposal(s) submitted in response to the following
call(s) for proposal(s):
- HORIZON-MSCA-2021-PF-01. European Commission. European Commission.
2021/11/01 - 2022/02/28. Membro de comissão. Membro da Comissão de avaliação das candidaturas ao curso de medicina da Universidade do Algarve- Avaliação e creditação de formação anterior de + de 100 candidaturas. Membro. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/02/12 - 2022/02/10. Membro de comissão. concurso documental internacional, para recrutamento na modalidade de contrato de trabalho em funções públicas por tempo indeterminado, para 1 posto de trabalho e provimento da respetiva vaga na categoria de professor catedrático na área disciplinar de Biomedicina, do mapa de pessoal docente da Universidade da Beira Interior, Edital n.º 192/2021 de 12 de Fev de 2021. Membro. Universidade da Beira Interior.
2021/12 - 2022/02/07. Comissão de avaliação.
21-FWO-PDOC-0556 - Harnessing transcriptome and proteome wide analyses and engineered reporter assays to unravel the immunopathogenesis of 'multisystem inflammatory syndrome in children' (MIS-C).. European Science Foundation. Research Foundation Flanders’ (FWO) .
2022/02. Júri de grau académico. PhD: Stress granules in Polyglutamine diseases: new targets for therapeutic intervention? . Presidente do júri. Adriana do Vale Marcelo (Doutoramento). Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2021/12 - 2022. Comissão de avaliação. A3ES_Convite para participar na avaliação de novos ciclos de estudo na area da Biologia / Biomedicina. A3ES.
2021/12 - 2022/01. Comissão de avaliação. Avaliação do relatório de atividades da Prof Associada do departamento de Biologia Animal da FCUL. Universidade de Lisboa, Faculdade de Ciências.
2021/12/01 - 2021/12/31. Comissão de avaliação. European Calcified Tissue Society- evaluation of applications for ECTS Academy. European Calcified Tissue Society. European Calcified Tissue Society.
2015/09 - 2021/12/13. Comissão de avaliação. Invitation to be part of the evaluation committee for annual applications for Medalhas l'Oreal. Fundação para a Ciência e a Tecnologia. Fundação L'Oreal.
2021/04 - 2021/10/31. Organização de evento. Organização do Encontro anual de doutorandos da Universidade do Algarve https://www.ualg.pt/en/doctoral-college (2021). Universidade do Algarve.
2021/09/21. Apresentação oral de trabalho. Holt Oram syndrome and Thalidomide toxicity: same molecular targets??
. Webinar series_COST action Eurosoftcalcnet. Tamas Aranyi (online, Hungria).
2021/09. Júri de grau académico. PhD: Development of a high throughput screening strategy for drug discovery: from marine fungi to stem cell application. Arguente principal. Pietro Marchese (Doutoramento). National University of Ireland Galway School of Medicine.
2021/07 - 2021/09. Comissão de avaliação. Participate in peer review of scientific proposals submitted to ERC starting grant 2021 call. European Research Council. European Research Council.
2021/07/30. Júri de grau académico. Provas de Agregação em Biomedicina: Celulas estaminais e terapias celulares. Arguente principal. Liliana Inácio Bernardino (Agregação). Universidade da Beira Interior Faculdade de Ciências da Saúde.
2020/06 - 2021/06. Arbitragem científica em conferência. European Calcified Tissue Society Congress . ECTS.
2021/05/28. Júri de grau académico. Provas de Agregação em Biologia, especialidade de Biologia Celular e Saúde. Arguente principal. Sandra Cristina Almeida Paiva (Agregação). Universidade do Minho Escola de Ciências.
2021 - 2021/04/26. Membro de comissão. Concurso internacional para ocupação de um posto de trabalho da carreira docente universitária, na categoria de Professor Associado, área disciplinar de Ciências da Vida, especialidade de Biofísica, Bioeletrónica e Biosensores da Faculdade de Ciências e Tecnologia da Universidade de Coimbra, cujo edital Edital n.º 273/2021, publicado em Diário da República, 2.ª série, n.º 44, de 04/03.. Membro. Universidade de Coimbra Departamento de Ciências da Vida.
2021/02 - 2021/03. Comissão de avaliação. Invitation to integrate evaluation committee for FWO postdoctoral applications. Research Foundation Flanders’ (FWO) . Research Foundation Flanders’ (FWO) .
Membro de associação. American Society for Bone and Mineral Research. member.
2012 - 2017. Orientação. "CONTRIBUTION TO THE MOLECULAR CHARACTERIZATION OF OSTEOARTHRITIS AND OSTEOPOROSIS PHENOTYPES ASSOCIATED WITH HEREDITARY HEMOCHROMATOSIS".Ciências Biomédicas (Doutoramento). Orientador.
2013 - 2016/10. Orientação. Characterization of the histological and genetic profile of articular damage in a hemochromatosis mouse model". .Medicina (Doutoramento). Orientador.
2011 - 2016. Orientação. Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans.Ciências Biomédicas (Doutoramento). Orientador.
2015. Júri de grau académico. DRUG REPURPOSING IN THE TREATMENT OF MELANOMA BRAIN METASTASIS. Vogal. BILLY SAMUEL HILL (Mestrado). Universidade do Algarve Faculdade de Ciências e Tecnologia.
2012 - 2015. Orientação. Genetic and functional analysis of the PDB6 locus in Paget´s disease of bone.Ciências Biomédicas (Doutoramento). Orientador.
2010 - 2015. Orientação. Mef2c: Expression, Regulation and Interaction with Target Genes in Health and Diseases.Ciências Biomédicas (Doutoramento). Orientador.
2010 - 2015. Orientação. Molecular Characterization of Gla Rich Protein (GRP) Gene Expression and Function.Ciências Biomédicas (Doutoramento). Orientador.
2009 - 2015. Orientação. IDENTIFICATION OF NOVEL MOLECULAR DETERMINANTS OF TISSUE MINERALIZATION IN FISH.Ciências Biomédicas (Doutoramento). Orientador.
2008 - 2015. Orientação. EVOLUTION, GENE REGULATION AND FUNCTIONAL ANALYSISN OF BMP2 IN FISH.Ciências Biomédicas (Doutoramento). Orientador.
2007 - 2014. Orientação. MOLECULAR STRUCTURE AND FUNCTIONAL ANALYSIS OF RUNX3 IN ZEBRAFISH.Ciências Biomédicas (Doutoramento). Orientador.
2009 - 2012/12. Orientação. Insights into molecular and cellular events involved in human pathological fusion of vertebral joints through the use of zebrafish as model organism.Molecular and Cellular Biology (Doutoramento). Coorientador.
2008 - 2012/05. Orientação. Characterization of metabolic pathways in the protozoan parasite Perkinsus atlanticus/olseni: Identification of potential targets for therapeutic drugs.Bioquimica (Doutoramento). Orientador.
2004/09/01 - 2012/02. Orientação. Abundance, site fidelity and population structure of humpbacks whales (Megaptera novaeangliae) in S. Tomé e Príncipe”.Population Genetics (Doutoramento). Coorientador.
2008 - 2012. Orientação. Study of Perkinsus Olseni Infection Mechanisms: Identification and Regulation of Parasite Genes Differentially Expressed in Response to Host and Environmental Stress.Biologia (Doutoramento). Orientador.
2005/04/01 - 2011/05. Orientação. Role of the transcriptional regulator FHL2 in bone formation: Identification of fish bone-specific target genes and regulatory mechanisms".Bioquimica (Doutoramento). Coorientador.
2005/04 - 2010/07. Orientação. Identification and characterization of a new calcium binding protein from sturgeon, Gla rich protein or GRP. Contribution to unveil its function in vertebrates.BIoquimica (Doutoramento). Coorientador.
2004 - 2008. Membro de comissão. Presidente da Sociedade Portuguesa de Bioquimica / President of the Portuguese Society of Biochemistry. Presidente / Vice-presidente. Sociedade Portuguesa de Bioquimica.
2003/09/01 - 2008. Orientação. Effects of vanadate and insulin treatment on proliferation, differentiation and mineralization of two fish bone derived cell lines, Vsa13 e Vsa116.Bioquimica (Doutoramento). Coorientador.
2003 - 2008. Orientação. Identification of P. Atlanticus genes differentially expressed in response to parasite-host interaction and development of an in vivo infestation system.Biologia Molecular (Doutoramento). Coorientador.
1999 - 2006/11. Orientação. Population genetics of an endangered species, the Bonelli’s eagle(Hieraaetus fasciatus).Population genetics (Doutoramento). Coorientador.
2000 - 2005/07. Orientação. “Functional analysis of bone-related Gla proteins from bony fish during skeletal development”..Biologia Molecular (Doutoramento). Orientador.
1998 - 2003/01. Orientação. Matrix Gla protein (MGP) de peixe: abordagem bioquímica e estrutural para o esclarecimento da sua função biológica.Bioqumica (Doutoramento). Orientador.
1998 - 2002/12. Orientação. Controle da expressão genética da proteina da matriz extracelular “matrix Gla protein”: estudos comparativos em anfíbios e peixes.Molecular biology. Orientador.
1995 - 2001. Orientação. Clonagem do gene da proteína BGP (Bone Gla protein) do peixe ósseo Sparus aurata (dourada). Organização molecular, expressão ao longo do desenvolvimento e implicações evolutivas”. .Molecular biology (Doutoramento). Orientador.

Projetos

Projetos
2025/01/01 - 2027/12/01. INOVACEL – SUSTENTABILIDADE E INOVAÇÃO NA AQUACULTURA CELULAR: UMA ABORDAGEM CIRCULAR COM MICROALGAS, SIID – I&D Empresarial – Operações em Copromoção INOVACEL. Investigador. Universidade do Algarve Centro de Ciências do Mar.
2022/10/01 - 2026/09/30. INTEC-International Network on Ectopic Calcifications, INTEC-International Network on Ectopic Calcifications. Outra. Universiteit Gent.
2018/08/01 - 2024/01/31. Aquaculture meets Biomedicine: Innovation in skeletal health research /BIOMEDAQU, Marie Sklodowska-Curie Actions-Innovative Training Networks . Investigador responsável. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2025/02/01 - 2026/07/31. ZFRescue_Rescuing functional defects in a zebrafish model of CDKL5 deficiency, CDKL5 PROGRAM OF EXCELLENCE GRANT PROGRAM. Investigador responsável. Centro de Ciências do Mar.
2021/01/01 - 2025/12/31. Centre for Marine and Environmental Research, 6817 - DCRRNI ID. Centro de Ciências do Mar; Universidade do Porto Faculdade de Desporto.
2020/01/01 - 2023/01/31. ZEBRABLOOM_Desenvolvimento de produtos comerciais formulados com microalgas para o enriquecimento de presas vivas de peixe-zebra, Projeto de co.promoção. Investigador. Universidade do Algarve.
2023/03/10 - 2025/03/09. Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using Zebrafish models, Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022 - PEX. Investigador responsável. Universidade do Algarve Centro de Ciências do Mar.
2023/03/10 - 2025/03/08. ZF screen_Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using Zebrafish models, Concurso de Projetos de I&D em Todos os Domínios Científicos - 2022. Investigador responsável. Centro de Ciências do Mar.
2019 - 2024/06/30. European transdisciplinary networking platform for marine biotechnology, COST ACTION CA18238. Outra. National Institute of Biology, Slovenia.
2020/03/01 - 2024/04/30. IDENTIFICATION OF NOVEL CDKL5 MOLECULAR TARGETS/PATHWAYS ASSOCIATED WITH SKELETAL DEFECTS PRESENT IN CDKL5 ASSOCIATED DISORDERS, PhD fellowships. Orientador. Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve; Centro de Ciências do Mar.
2020/04/01 - 2024/03/31. PhysPath-KS (EJPRD/0004/2019) Understanding the pathophysiology of Keutel Syndrome: A path towards cure, EJPRD - European Joint Programme on Rare Diseases. Outra. Universidade do Algarve Centro de Ciências do Mar.
2020/04/01 - 2024/03/31. Understanding the pathophysiology of Keutel Syndrome: A path towards cure, EJP RD - Programa Europeu Conjunto para as Doenças Raras 2019. Universidade do Algarve Centro de Ciências do Mar.
2020/04/01 - 2024/03/31. Understanding the pathophysiology of Keutel Syndrome: A path towards cure, EJP RD - Programa Europeu Conjunto para as Doenças Raras 2019. Universidade do Algarve Centro de Ciências do Mar.
2009 - 2024. Lab-it_Laboratório Itinerante de Biologia Molecular, Lab-it_Laboratório Itinerante de Biologia Molecular. Investigador responsável. Ciência Viva.
2021/01/01 - 2023/06/30. MarEmPó, COMPETE2020, CRESC Algarve 2020, PT2020 e FEDER. Investigador. Universidade do Algarve - Campus de Gambelas.
2018/11/01 - 2022/04/30. KCITAR ALGARVE, PORegional Algarve. Investigador. Universidade do Algarve - Campus de Gambelas.
2019/02/01 - 2021/12/31. Zebrafish as model to analyse CDKL5 function, Orphan Disease Center. Investigador responsável. Centro de Ciências do Mar; Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve.
2018/01/01 - 2021/07/31. Novos compostos marinhos como fonte nutricional para uma melhoria de Qualidade e Bem estar de peixes em aquacultura. , MAR2020. Investigador responsável. Universidade do Algarve - Campus de Gambelas.
2018/01/01 - 2021/07/31. BLUE biotechnology as a road for innovation on human health aiming smart growth in Atlantic Area., Transnational Cooperation Programme Atlantic Area (Porto). Investigador responsável. Universidade do Algarve - Campus de Gambelas.
2017/11 - 2021/07. OSTEOMAR (16-02-01-FMP-0057) Novos compostos marinhos como fonte nutricional para uma melhoria da qualidade e bem-estar de peixes em aquacultura, MAR2020. Universidade do Algarve.
2017/04/01 - 2021/06/30. RED transfronteriza para el desarrollo de productos innovadores con microALGAs, European Commission (Brussels, Spain) INTERREG – POCTEP.. Investigador. Universidade do Algarve.
2017/04/01 - 2021/06/30. Desenvolvimento e implementação de alimentos suplementados em macroalgas ricas em vitamina K no cultivo do Linguado, Mar2020. Investigador. Universidade do Algarve - Campus de Gambelas.
2019/01/01 - 2019/12/31. Centre of Marine Sciences, 6817 - DCRRNI ID. Centro de Ciências do Mar.
2016/09/01 - 2019/12/31. Insights into Matrix Gla protein (MGP) regulation in colorectal cancer, Prize from Portuguese Society of Gastroenterology. Investigador responsável. Centro de Ciências do Mar.
2016/04/01 - 2019/03/31. Desenvolvimento de uma prémistura de micronutrientes para optimizar as dietas para larvas de peixes marinhos. , CRESC Algarve 2020. Investigador. Universidade do Algarve.
2013/10/01 - 2018/09/30. Clinical and molecular heterogeneity of Paget's disease of bone, Canadian Institutes of Health Research (CIHR) Operating grant program. Investigador. Centro de Ciências do Mar.
2014/11/01 - 2015/12/31. Estudo piloto para melhoramento do status nutricional em vitamina K: optimização da reprodução e demonstração da melhoria na qualidade larvar de linguado, PROMAR. Investigador. Programa Operacional Pesca 2007-2013 (PROMAR).
2012/01/01 - 2015/07/31. DEEPBONE - Bone biology of deep-sea teleost fish, Concurso de Projectos de Investigação Científica e Desenvolvimento Tecnológico em todos os Domínios Científicos - 2010. Investigador. Centro de Ciências do Mar.
2012 - 2015. iONE-FP7 project Implantable Organic Nano-Electronics, I-ONE. Investigador. Universidade do Algarve.
2012 - 2015. Desenvolvimento de rações optimizados para desenvolvimennto e crescimento do peixe zebra, um modelo com aplicações biomédicas, QREN I&DT – Co-promoção. Investigador. Universidade do Algarve.
2011/06/01 - 2014/05/31. Intelligent Cell Surfaces (ICS), EUROCORES. Investigador. Universidade do Algarve.
2012 - 2014. Development of innovating biomedical products from marine resources valorisation., MARMED. Investigador. Universidade do Algarve Departamento de Ciências Biomédicas e Medicina.
2010/01/01 - 2013/07/31. Studies for the establishement of GRP as a biomarker for vascular calcification, Concurso para Projectos de I&D em todos os Domínios Científicos - 2008. Investigador. Centro de Ciências do Mar; Hospital de Faro; University of Minnesota Twin Cities Department of Medicine; Instituto de Biotecnologia e Bioengenharia; Universidade do Algarve.
2010 - 2013. Effects of dietary vitamin K supplementation on growth and skeletal development of teleost fish , SpecialK . Investigador. Centro de Ciências do Mar.
2009 - 2013. Development and characterization of zebrafish stem cells: implications for transgenesis , FISHCell. Investigador. Centro de Ciências do Mar.
2011/01/01 - 2012/12/31. Strategic Project - LA 15 - 2011-2012, 6820 - DCRRNI ID. Centro de Investigação Marinha e Ambiental; Universidade do Porto Faculdade de Desporto; Centro de Ciências do Mar.
2008/08/01 - 2011/12/31. Dietary fatty acids as modulators of bone metabolism in gilthead sea bream (Sparus aurata) - FATTYBONE, Concurso para Projectos de I&D em todos os Domínios Científicos - 2006. Investigador. Centro de Ciências do Mar.
2007/08/01 - 2010/07/31. Characterization of isoprenoids biosynthesis and determination of potential therapeutic targets, Concurso para Projectos de I&D em todos os Domínios Científicos - 2006. Investigador responsável. Centro de Ciências do Mar.
2006/01/01 - 2008/12/31. Effects of xenobiotics in skeleton development and fin regeneration in fish, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Investigador. Centro de Ciências do Mar.
2005/09/01 - 2008/06/30. MGP functional role regarding local regulation of extracellular matrix mineralization-Identification of the structural motifs responsible for its function, POCI. Universidade do Algarve Centro de Ciências do Mar.
2005/06/01 - 2008/06/30. Spatial-temporal pattern of expression and regulation of Matrix Gla Protein (MGP) during early development in X. laevis, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Investigador. Centro de Ciências do Mar; Universidade do Algarve.
2005/06/01 - 2008/05/31. Characterisation of the folate and purine metabolism in the protozoan parasite Perkinsus atlanticus: identification of genes involved in these pathways and potential therapeuthic targets, Concurso para Projectos de I&D em todos os Domínios Científicos - 2004. Investigador responsável. Centro de Ciências do Mar.
1997 - 2001. The conservation of Bonelli's eagle Hieraaetus fasciatus in the mediterranean context. Ecology, demography and genetics of the Portuguese populations, Programa PRAXIS XXI.
1998/05/01 - 2000/12/31. NEPGENES - Estimation of population sizes in Norway Lobster, a new methodology, Study Projects (in support of the CFP). Universidade do Algarve; Universidade do Algarve Centro de Ciências do Mar.

Produções

2009. "Lab-it Laboratorio Itinerante em Genética Molecular". Registada.
2009. "Lab-it". Registada.
Varela, Tatiana; Varela, Débora; Santos, João; Hernández, Ana; Domingues, Max; Pinto, Vanessa; Conceição, Natércia; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. 2026. Rescuing functional defects in a zebrafish model of CDKL5 deficiency disorder: Contribution to the identification of new therapeutic compounds. https://doi.org/10.64898/2026.03.12.711124
2025. "EPIGENETIC REGULATION OF ZNF687 IN BONE CELLS: ELUCIDATION OF ITS ROLE IN THE PROGRESSION OF PAGET'S DISEASE OF BONE". Doutoramento.
Varela, Tatiana; Varela, Débora; Conceição, Natércia; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. 2025. "Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal Development". International Journal of Molecular Sciences, 26 (13). https://doi.org/10.3390/ijms26136069
Carletti, Alessio; Pes, Katia; Tarasco, Marco; Rosa, Joana T.; Poudel, Sunil; Pereira, Hugo Galvão; Louro, Bruno; et al. Autor correspondente: Gavaia, Paulo J.. 2025. "Immunomodulatory inhibition of osteoclastogenesis by a marine microalgal ethanol fraction targeting T-cells, antigen presentation, and macrophage fate". Frontiers in Immunology, 16. https://doi.org/10.3389/fimmu.2025.1655321
2025. "Caracterização molecular, funcional e morfológica de peixe-zebra mutantes associados à síndrome de Keutel". Mestrado.
2025. "Functional characterization of Matrix Gla protein (MGP) domains and its role on mineralization". Mestrado.
Carletti, Alessio; Gavaia, Paulo Jorge; Cancela, Maria Leonor; Laizé, Vincent. 2024. "Metabolic bone disorders and the promise of marine osteoactive compounds". Cellular and Molecular Life Sciences, 81 (1). https://doi.org/10.1007/s00018-023-05033-x
ML Cancela; Conceicao, Natercia; Caiado, H.. Autor correspondente: Conceicao, Natercia. 2024. "Transcriptional regulation of the human MGP promoter: identification of downstream repressors". Int. J. Mol. Sci. , 25.
Leonor Cancela; Gavaia, P. "Novos compostos marinhos como fonte nutricional para uma melhoria da qualidade e bem-estar de peixe em aquacultura.". Aspectos , março, 2024. https://www.calameo.com/read/0046011493645a593a81e
Kussaba Miguel, Larissa; Simão, Márcio; Conceição, Natércia; M Leonor Cancela. 2024. Histological characterization of zebrafish mgp mutant (MGP_¿18) . Em IX SPB Clinical Biochemistry Workshop.
D Varela; T Varela; Conceição, Natércia; ML Cancela. 2024. miR-142a-3p regulates ZNF687 during MC3T3-E1 osteoblast differentiation . Em IX Workshop de Bioquímica Clínica.
M Chaves; B Ferreira; J Galhardas; S Guerreiro; E Houghton-Larsen; T Nehring; E Ninou; et al. 2024. Bioinformatic analysis identifies Oryzias latipes as a valid new model for analysis of MGP gene function . Em IX Workshop de Bioquímica Clínica.
L Geraldo; L Miguel; Conceição, Natércia; J Santos; JK Venkatesan; M Cucchiarini; ML Cancela. 2024. rAAV-mediated overexpression of Gla-deficient mutant Matrix Gla Protein limits its potential to inhibit mineralization in SaOS2 cells . Em IX Workshop de Bioquímica Clínica.
Simão, Márcio; Geraldo, Linda; Rodrigues, Carolina ; Conceição, Natércia; Gavaia, Paulo J; Venkatesan, Jagadeesh K. ; Cucchiarini, Magali ; Leonor Cancela. 2024. rAAV-mediated transduction of ATDC5 and Saos-2 cells with mutant Matrix Gla Protein (MGP) transcripts showed the impact of Gla domain and Serine phosphorylation on the inhibition of mineralization . Em Ectopic calcification: Friend or foe? Anual INTEC meeting.
Simão, Márcio; Giovanni do Carmo; Kussaba Miguel, Larissa; Conceição, Natércia; Gavaia, Paulo J; Leonor Cancela. 2024. Analysis of the impact of mgp_¿10 mutation on zebrafish bone metabolism. Em V International Meeting of the Portuguese Society of Genetics.
Sares, Daniel; Simão, Márcio; Martins, Gil; Cucchiarini, Magali ; Venkatesan, Jagadeesh K. ; Leonor Cancela; Gavaia, Paulo J. 2024. Analysis of mineralization phenotypes in zebrafish larvae expressing a dominant negative mgp mutant. Em Ectopic calcification: Friend or foe? Anual INTEC meeting.
Poudel, Sunil. 2023. "Effect of Antioxidant and Pro-oxidant on Bone mineralization and Remodelling". Doutoramento. http://hdl.handle.net/10400.1/19664
Adrião, Andreia; Mariano, Sara; Mariano, José; Gavaia, Paulo J.; Cancela, M. Leonor; Vitorino, Marta; Conceição, Natércia. 2023. "mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour". Biomolecules, 13 (5). https://doi.org/10.3390/biom13050805
Santos, João M. A.; Laizé, Vincent; Gavaia, Paulo J.; Conceição, Natércia; Cancela, M. Leonor. 2023. "Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies". International Journal of Molecular Sciences, 24 (4). https://doi.org/10.3390/ijms24043366
Saavedra, Carlos; Milan, Massimo; Leite, Ricardo B.; Cordero, David; Patarnello, Tomaso; Cancela, M. Leonor; Bargelloni, Luca. 2023. "Transcriptional Profiling of Populations in the Clam Ruditapes decussatus Suggests Genetically Determined Differentiation in Gene Expression along Parallel Temperature Gradients and between Races of the Atlantic Ocean and West Mediterranean Sea". Fishes, 8 (4). https://doi.org/10.3390/fishes8040203
Carletti, Alessio. 2023. "Effect of marine-derived extracts on mineralogenesis". Doutoramento. http://hdl.handle.net/10400.1/20069
Varela, Débora; Varela, Tatiana; Conceição, Natércia; Cancela, M. Leonor. 2023. "Regulation of human ZNF687, a gene associated with Paget's disease of bone". The International Journal of Biochemistry & Cell Biology, 154. https://doi.org/10.1016/j.biocel.2022.106332
Carletti, Alessio; Rosa, Joana T.; Pes, Katia; Borges, Inês; Santos, Tamára; Barreira, Luísa; Varela, João; et al. 2023. "The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models". Cellular and Molecular Life Sciences, 80 (10). https://doi.org/10.1007/s00018-023-04953-y
D Varela; T Varela; Conceição, Natércia; ML Cancela. 2023. Effect of bone-related transcription factors and methylation on ZNF687 transcriptional regulation. Em 50th ECTS.
T Varela; D Varela; Conceição, Natércia; ML Cancela. 2023. Zebrafish mutant for CDKL5 display neuronal defects resembling CDKL5 deficiency disorder. Em FENS Regional Meeting 2023.
D Varela; T Varela; Conceição, Natércia; ML Cancela. 2023. Post-transcriptional regulation of znf687 during mc3t3-e1 osteoblast differentiation . Em IV International Meeting of the Portuguese Society of Genetics.
T Varela; D Varela; Conceição, Natércia; ML Cancela. 2023. Zebrafish mutant as a model for cdkl5 deficiency disorder: insights into neuron-skeletal defects . Em IV International Meeting of the Portuguese Society of Genetics.
T Varela; J Santos; A Rodriguez; V Pinto; D Varela; Conceição, Natércia; ML Cancela. 2023. Screening of drugs in zebrafish model to rescue cdkl5 deficiency disorder phenotype. Em IV International Meeting of the Portuguese Society of Genetics.
M Simão; L Miguel; Conceição, Natércia; J Santos; ML Cancela. 2023. Bioinformatic characterization of two MGP mutant proteins expressed in zebrafish (Danio rerio) . Em IV International Meeting of the Portuguese Society of Genetics.
T Varela; J Santos; A Hernández-Rodríguez; V Pinto; D Varela; Conceição, Natércia; ML Cancela. 2023. Zebrafish-based drug screening identifies candidate molecules for CDKL5 Deficiency Disorder therapeutic applications . Em CDKL5 Forum.
Adrião, Andreia; Santana, Isabel; Ribeiro, Carolina; Cancela, M. Leonor; Conceição, Natércia; Grazina, Manuela. 2022. "Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration". Neurological Sciences, 43 (1): 319-326. https://doi.org/10.1007/s10072-021-05269-0
Alfaia, Ana Sofia de Almeida. 2022. "ANALYSIS OF THE MUTATIONS ASSOCIATED WITH PAGET DISEASE OF BONE IN A SET OF PATIENTS FROM ALENTEJO AND ALGARVE". Mestrado. http://hdl.handle.net/10400.1/18645
2022. "Função da Elastina no desenvolvimento das calcificações ectópicas da cartilagem associadas a uma deficiência em MGP: contribuição para o estudo da sindrome de Keutel". Mestrado.
Poudel, Sunil; Izquierdo M; Leonor Cancela; Gavaia, P; Sunil Poudel; Marisol Izquierdo; Maria Leonor Cancela; Paulo J. Gavaia. 2022. "Reversal of Doxorubicin-induced bone loss and mineralization by supplementation of Resveratrol and MitoTEMPO in the early development of Sparus aurata. ". Nutrients, 14 (6): 1154-1154. https://doi.org/10.3390/nu14061154
Cardeira-da-Silva, João; Bensimon-Brito, Anabela; Tarasco, Marco; Brandão, Ana S.; Rosa, Joana T.; Borbinha, Jorge; Almeida, Paulo J.; et al. 2022. "Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish". Proceedings of the National Academy of Sciences, 119 (48). https://doi.org/10.1073/pnas.2209231119
Sunil Poudel; Gil Martins; M. Leonor Cancela; Paulo J. Gavaia. 2022. "Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish". Nutrients. https://doi.org/10.3390/nu14234959
Joana T. Rosa; Marco Tarasco; Paulo J. Gavaia; M. Leonor Cancela; Vincent Laizé. 2022. "Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy". Pharmaceuticals. https://doi.org/10.3390/ph15080983
Márcio Simão; Natércia Conceição; Susana Imaginário; João Amaro; Maria Leonor Cancela. 2022. "Lab-It Is Taking Molecular Genetics to School". BioChem. https://doi.org/10.3390/biochem2020011
Poudel, Sunil; Martins, Gil; Cancela, M. Leonor; Gavaia, Paulo J.. 2022. "Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation". International Journal of Molecular Sciences, 23 (23). https://doi.org/10.3390/ijms232315160
João Cardeira-da-Silva; Anabela Bensimon-Brito; Marco Tarasco; Ana S. Brandão; Joana Rosa; Paulo J. Almeida; António Jacinto; et al. 2022. Fin ray branching is defined by TRAP+ osteolytic tubules. https://doi.org/10.1101/2022.05.09.491182
Tarasco, Marco; Gavaia, Paulo J.; Bensimon-Brito, Anabela; Cordelières, Fabrice P.; Santos, Tamára; Martins, Gil; de Castro, Daniela T.; et al. 2022. "Effects of pristine or contaminated polyethylene microplastics on zebrafish development". Chemosphere, 303. https://doi.org/10.1016/j.chemosphere.2022.135198
Caiado, Helena Isabel Rosa Pinto. 2022. "Molecular basis for the epigenetic regulation of MGP in cancer". Doutoramento. http://hdl.handle.net/10400.1/19633
Antunes, Célia M.; Costa, Ana R.; Palma, Patrícia; Gastalho, Carlos; Marques, Mariana; Galveias, Ana; Cancela, Leonor; Aureliano, Manuel. 2022. XXI SPB CONGRESS BOOK. Universidade de Évora. http://hdl.handle.net/10174/31139
Tarasco, Marco. 2022. "How microplastics and adsorbed pollutants affect zebrafish development?". Doutoramento. http://hdl.handle.net/10400.1/18456
Varela, Tatiana; Varela, Débora; Martins, Gil; Conceição, Natércia; Cancela, M. Leonor. 2022. "Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder". Scientific Reports, 12 (1). https://doi.org/10.1038/s41598-022-13364-1
Silva, Iris A.L.; Varela, Débora; Cancela, M. Leonor; Conceição, Natércia. 2022. "Zebrafish optineurin: genomic organization and transcription regulation". Genome, 65 (10): 513-523. https://doi.org/10.1139/gen-2022-0019
Carletti, Alessio; Cardoso, Carlos; Lobo-Arteaga, Jorge; Sales, Sabrina; Juliao, Diana; Ferreira, Inês; Chainho, Paula; et al. 2022. "Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae". Frontiers in Nutrition, 9. https://doi.org/10.3389/fnut.2022.888360
Tatiana Varela; Débora Varela; Conceição, Natércia; M Leonor Cancela. 2022. Zebrafish: a promising animal model to study CDKL5 deficiency disorder. Em 11th European Conference on Rare Diseases & Orphan Products.
Tatiana Varela; Débora Varela; Conceição, Natércia; M Leonor Cancela. 2022. cdkl5 mutant zebrafish recapitulates key phenotypes of CDKL5 deficiency disorder. Em ABC Days – V Annual Meeting of the Algarve Biomedical Center.
Simão, Márcio; Conceição, Natércia; Leonor Cancela. 2022. Impact of Lab-it to consolidate molecular genetics concepts in high schools within the context of Biomedical sciences. Em III International Meeting of the Portuguese Society of Genetics.
M Vitorino; Conceição, Natércia; D Varela; G Tiscornia; ML Cancela. 2022. Is MGP involved in Acomys cahirinus ear regeneration? . Em III International Meeting of the Portuguese Society of Genetics.
M Vitorino; Conceição, Natércia; D Varela; Tiscornia, Gustavo; ML Cancela. 2022. The use of Acomys cahirinus to study the role of Matrix Gla Protein in regeneration. Em INTEC kick-off meeting.
T Varela; D Varela; Conceição, Natércia; ML Cancela. 2022. Zebrafish model for the screening of drugs to rescue cdkl5 deficiency disorder phenotypes . Em 2022 CDKL5 Forum.
T Varela; D Varela; Conceição, Natércia; ML Cancela. 2022. Zebrafish Mutant for Cdkl5 Mimics Phenotypes Associated with Human CDKL5 Deficiency Disorder. Em 26th Annual Meeting Sociedade Portuguesa de Genética Humana.
D Varela; T Varela; Conceição, Natércia; ML Cancela. 2022. Regulation of Znf687 during Osteoblast Differentiation. Em 26th Annual Meeting Sociedade Portuguesa de Genética Humana.
Tatiana Varela; Débora Varela; Conceição, Natércia; M Leonor Cancela. 2022. Involvement of cdkl5 gene during osteoblast proliferation and differentiation.. Em Ciência 2022 ¿ Encontro com a Ciência e Tecnologia em Portugal.
JMA Santos; RCR Abreu; C Rodrigues; I Borges; Conceição, Natércia; Gavaia, PJ; Laizé, Vincent; ML Cancela. 2022. Zebrafish model to study mechanisms of ectopic mineralization associated to elastinopathies. . Em III International Meeting of the Portuguese Society of Genetics.
Poudel, Sunil; Martins, Gil; M Leonor Cancela; Gavaia, P. 2022. The Sirt 1 activator resveratrol counteracts the doxorubicin-induced effects on osteoclastogenesis. Em VI Interdisciplinary Approaches in Fish Skeletal Biology.
Poudel, Sunil; Martins, Gil; M Leonor Cancela; Gavaia, P. 2022. Regular supplementation with antioxidants rescues doxorubicin-induced bone deformities and mineralization delay in zebrafish. Em VI Interdisciplinary Approaches in Fish Skeletal Biology.
Rotter, Ana; Barbier, Michéle; Bertoni, Francesco; Bones, Atle M.; Cancela, M. Leonor; Carlsson, Jens; Carvalho, Maria F.; et al. 2021. "The Essentials of Marine Biotechnology". Frontiers in Marine Science, 8. https://doi.org/10.3389/fmars.2021.629629
Kempf, Hervé; Murshed, Monzur; ML Cancela; Laizé, V; Conceiçao, Natercia. 2021. "Keutel Syndrome, a Review of 50 Years of Literature". Frontiers in Cell and Developmental Biology, 9 (642136): 275-283. https://doi.org/10.3389/fcell.2021.642136
Varela, Débora; Varela, Tatiana; Conceição, Natércia; Ferreira, Ângela; Marques, Nuno; Silva, Ana Paula; Azevedo, Pedro; et al. Autor correspondente: Cancela, M. Leonor. 2021. "Functional analysis of two novel TBX5 variants present in individuals with Holt Oram syndrome with different clinical manifestations". Molecular Genetics and Genomics, 296 (4): 809-821. https://doi.org/10.1007/s00438-021-01781-2
Varela, Tatiana; Conceição, Natércia; Laizé, Vincent; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. 2021. "Transcriptional regulation of human
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Varela, Débora; Conceição, Natércia; Cancela, M. Leonor. Autor correspondente: Cancela, M. Leonor. 2021. "Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors". Gene, 768. https://doi.org/10.1016/j.gene.2020.145322
Roberto, Vânia P.; Surget, Gwladys; Le Lann, Klervi; Mira, Sara; Tarasco, Marco; Guérard, Fabienne; Poupart, Nathalie; et al. Autor correspondente: Cancela, M. Leonor. 2021. "Antioxidant, Mineralogenic and Osteogenic Activities of Spartina alterniflora and Salicornia fragilis Extracts Rich in Polyphenols". Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.719438
Tarasco, Marco; Gavaia, Paulo J.; Bensimon-Brito, Anabela; Cardeira-da-Silva, João; Ramkumar, Srinath; Cordelières, Fabrice P.; Günther, Stefan; et al. 2021. "New insights into benzo[¿]pyrene osteotoxicity in zebrafish". Ecotoxicology and Environmental Safety, 226. https://doi.org/10.1016/j.ecoenv.2021.112838
Simão, Márcio; Cancela, M. Leonor. 2021. "Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms". Biochemical Society Transactions, 49 (2): 747-759. https://doi.org/10.1042/bst20200672
ML Cancela; Laizé, V; Rosa, Joana; Laizé, Vincent; Rosa, Joana T.; Tarasco, Marco; Cancela, M. Leonor. 2021. "Status, challenges, and perspectives of fish cell culture—Focus on cell lines capable of in vitro mineralization". Em Cellular and molecular approaches in fish biology , editado por Fernández, Ignacio; Fernandes, JMO; Ignacio, Fernandez, 381-404. Elsevier. https://doi.org/10.1016/b978-0-12-822273-7.00004-5
Rosa, Joana T.; Laizé, Vincent; Gavaia, Paulo J.; Cancela, M. Leonor. 2021. "Fish Models of Induced Osteoporosis". Frontiers in Cell and Developmental Biology, 9. https://doi.org/10.3389/fcell.2021.672424
Kumar, Navdeep; Carletti, Alessio; Gavaia, Paulo J.; Muller, Marc; Cancela, M. Leonor; Geurts, Pierre; Marée, Raphaël; et al. 2021. "Deep Learning Approaches for Head and Operculum Segmentation in Zebrafish Microscopy Images". Em Computer Analysis of Images and Patterns, 154-164. 1ª ed. Vol. 13052. Liege, Bélgica: Springer International Publishing. https://doi.org/10.1007/978-3-030-89128-2_15
Cancela, M Leonor; Conceiçao, Natercia; Varela, Tatiana; Laizé, V. 2021. "A expressão dos transcritos do gene DUSP4 como potencial biomarcador no cancro colorretal. ". UALGORITMO, 3: 25-28.
Borges, Inês Sá da Costa Pereira. 2021. "Caracterização de duas linhas de peixe-zebra mutantes para a elastina no estudo da síndrome de Keutel". Mestrado. http://hdl.handle.net/10400.1/18174
Silva, Joel Mourato da. 2021. "Characterization of 5´ and 3´ UTRs from Bone morphogenetic protein receptor type 1A (Bmpr1A) transcripts under the context of bone metabolism". Mestrado. http://hdl.handle.net/10400.1/18181
Rosa, Joana; Carletti, Alessio; Varela, Tatiana; Gavaia, Paulo J.; Cancela, M. Leonor; Laizé, Vincent. 2021. "Identification of bone anabolic compounds of marine origin using a zebrafish pipeline". Bone Reports, 14. https://doi.org/10.1016/j.bonr.2021.100985
Poudel, Sunil; Izquierdo, Marisol; Cancela, M. Leonor; Gavaia, Paulo J.. 2021. "Reversal of Doxorubicin-induced bone loss by antioxidant supplement". Bone Reports, 14. https://doi.org/10.1016/j.bonr.2021.100984
D Varela; T Varela; J Rosa; A Nunes; Conceição, Natércia; ML Cancela. 2021. "Zebrafish as a model to assess the effects of thalidomide in limb development. ". Trabalho apresentado em Bone Reports , 14.
Célia M. Antunes; Ana Rodrigues Costa; Palma, Patrícia; Carlos Gastalho; Mariana Marques; Galveias, Ana; Leonor Cancela; Manuel Aureliano. 2021. XXI SPB CONGRESS BOOK - http://hdl.handle.net/10174/31139. Portugal. http://hdl.handle.net/10174/31139
Tatiana Varela; Gil Martins; Débora Varela; Conceição, Natércia; M Leonor Cancela. Autor correspondente: Tatiana Varela. 2021. Characterization of zebrafish cdkl5 knockdown using a morpholino approach. Em XXI National Congress of Biochemistry.
Antunes, Célia; Ana Rodrigues Costa; Palma, Patrícia; Gastalho, C. M.; Mariana Marques; Galveias, Ana; M Leonor Cancela; Manuel Aureliano. 2021. Biochemistry Congress Book. Évora, Portugal: http://hdl.handle.net/10174/31139. http://hdl.handle.net/10174/31139
Joana Rosa; Alessio Carletti; Tatiana Varela; Gavaia, Paulo; M Leonor Cancela; Vincent Laizé. Autor correspondente: Joana Rosa. 2021. Identification and evaluation of marine osteogenic extracts using a zebrafish screening pipeline. Em XII European Conference on Marine Natural Products.
Tarasco, Marco; Martins, Gil; Gavaia, Paulo J.; Bebianno, Maria J.; Cancela, M. Leonor; Laizé, Vincent. 2020. "ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts". Zebrafish, 17 (1): 18-26. https://doi.org/10.1089/zeb.2019.1801
Simão, Márcio; Leite, Ricardo B.; Cancela, M. Leonor. 2020. "Expression of four new ferritins from grooved carpet shell clam Ruditapes decussatus challenged with Perkinsus olseni and metals (Cd, Cu and Zn)". Aquatic Toxicology, 229. https://doi.org/10.1016/j.aquatox.2020.105675
Rotter, Ana; Bacu, Ariola; Barbier, Michèle; Bertoni, Francesco; Bones, Atle M.; Cancela, M. Leonor; Carlsson, Jens; et al. 2020. "A New Network for the Advancement of Marine Biotechnology in Europe and Beyond". Frontiers in Marine Science, 7 (278). https://doi.org/10.3389/fmars.2020.00278
Varela, Tatiana; Laizé, Vincent; Conceição, Natércia; Caldeira, Paulo; Marreiros, Ana; Guerreiro, Horácio; Cancela, M Leonor. 2020. "Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer". Biomarkers in Medicine, 14 (8): 639-650. https://doi.org/10.2217/bmm-2019-0369
Vijayakumar, Parameswaran; Cardeira, João; Laizé, Vincent; Gavaia, Paulo J.; Cancela, M. Leonor. 2020. "Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages". Marine Biotechnology, 22 (3): 333-347. https://doi.org/10.1007/s10126-019-09937-3
Caiado, Helena; Conceição, Natércia; Tiago, Daniel; Marreiros, Ana; Vicente, Susana; Enriquez, Jose Luis; Vaz, Ana Margarida; et al. 2020. "Data on the evaluation of FGF2 gene expression in Colorectal Cancer". Data in Brief, 31. https://doi.org/10.1016/j.dib.2020.105765
Shea, M. Kyla; Booth, Sarah L.; Harshman, Stephanie G.; Smith, Donald; Carlson, Cathy S.; Harper, Lindsey; Armstrong, Alexandra R.; et al. 2020. "The effect of vitamin K insufficiency on histological and structural properties of knee joints in aging mice". Osteoarthritis and Cartilage Open, 2 (3). https://doi.org/10.1016/j.ocarto.2020.100078
Tarasco, Marco; Cordelières, Fabrice P.; Cancela, M. Leonor; Laizé, Vincent. 2020. "ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures". Bone, 138. https://doi.org/10.1016/j.bone.2020.115480
Carletti, Alessio; Cardoso, Carlos; Juliao, Diana; Arteaga, Jorge; Sales, Sabrina; Gaudêncio, Maria; Ferreira, Inês; et al. 2020. "Biopotential of sea cucumbers (Echinodermata) and tunicates (Chordata) from the western coast of Portugal for the prevention and treatment of chronic illnesses". Em Proceedings of The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease. Reino Unido: MDPI. https://doi.org/10.3390/iecn2020-06994
ML Cancela. 2020. "Isolation, Culture, and Differentiation of Blastema Cells from the Regenerating Caudal Fin of Zebrafish". Fishes. https://doi.org/10.3390/fishes5010006
ML Cancela. 2020. "Evaluation of MGP gene expression in colorectal cancer". Gene. https://doi.org/10.1016/j.gene.2019.144120
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Varela, Tatiana; Varela, Débora; Vitorino, Marta; Conceição, Natércia; Cancela, M. Leonor; Martins, Gil. 2020. "Zebrafish: an interesting model to study CDKL5 deficiency disorder". https://doi.org/10.1097/MD.0000000000019291
D Varela; N Conceição; ML Cancela. 2020. "Regulation of ZNF687 by the bone-related transcription factors DLX5 and HOXD13 through binding sites overlapping CpG sites". Trabalho apresentado em Medicine - Abstract of 24rd Annual Meeting of the Portuguese-Society-of-Human-Genetics. , Portugal, 100 (4).
Débora Varela; J Zortéa; J Rosa; A Nunes; Conceição, Natércia; ML Cancela. 2020. Functionality of binding sites for bone-related transcription factors overlapping CpG sites on ZNF687, a gene associated with Paget’s disease of bone. Em International Meeting of the Portuguese Society of Genetics.
Tatiana Varela; G Martins; Débora Varela; M Vitorino; Conceição, Natércia; ML Cancela. 2020. Contribution to validate zebrafish as model for CDKL5 deficiency disorder using a morpholino-mediated approach. Em International Meeting of the Portuguese Society of Genetics.
Tatiana Varela; IS Morais; A Nechaeva; ML Cancela; L Faísca; A Reis; Conceição, Natércia. 2020. Study of the candidate gene KIAA0319 for dyslexia in the Portuguese population. Em International Meeting of the Portuguese Society of Genetics.
AS Alfaia; Conceição, Natércia; G Sequeira; P Carvalho; V Teixeira; C Ribeiro; ML Cancela. 2020. Genetic analysis of Optineurin and APEX variants in two families from south-center of Portugal with Paget Disease of Bone history. Em International Meeting of the Portuguese Society of Genetics.
H Caiado; Conceição, Natércia; ML Cancela. 2020. Regulation of Matrix Gla Protein gene through epigenetic mechanisms in Bladder Cancer. Em International Meeting of the Portuguese Society of Genetics.
H Caiado; Conceição, Natércia; D Tiago; A Marreiros; AM Vaz; A Antunes; H Guerreiro; P Caldeira; ML Cancela. 2020. MGP, FGF2 and RUNX2 as important predictor factors to differentiate colorectal adenocarcinoma prognosis amongst patients. Em International Meeting of the Portuguese Society of Genetics.
AIM Marques; I Meirinho; J Mustacová; AI Favinha; EG Dimou; ALC Figueiredo; D Shkabura; et al. 2020. Danio rerio as a model to study ERCC1 function in bone formation. Em International Meeting of the Portuguese Society of Genetics.
Débora Varela; Tatiana Varela; P Azevedo; A Ferreira; A.Silva; Nuno Marques; A Camacho; et al. 2020. Two novel TBX5 mutations in Holt-Oram syndrome patients with different clinical manifestations. Em International Meeting of the Portuguese Society of Genetics.
Débora Varela; Tatiana Varela; J Rosa; A Nunes; Conceição, Natércia; ML Cancela. 2020. The effect of thalidomide on phenotype and gene expression in zebrafish. Em International Meeting of the Portuguese Society of Genetics.
Felício, Daniela; António Camacho; ML Cancela; Simão, Márcio. 2020. Identification and characterization of polymorphisms in HLA-B*27 allele in ankylosing spondylitis patients. Em 1st International Meeting of the Portuguese Society of Genetics.
Carletti, Alessio; Katkam N. Gangadhar; Nathana L. Cristofoli; Barreira, Luísa; Hugo Galvão Caiano Pereira; Varela, João; M Leonor Cancela; Laizé, Vincent; Gavaia, Paulo. 2020. "The potential of Tetraselmis sp. CTP4 as a source for bone anabolic compounds in zebrafish". Trabalho apresentado em 11th EUROPEAN ZEBRAFISH MEETING 2020, Prague, República Checa.
Tatiana Varela; Martins, Gil; Débora Varela; Vitorino, Marta; Conceição, Natércia; M Leonor Cancela. 2020. Contribution to validate zebrafish as a model for CDKL5 deficiency disorder using a morpholino-mediated approach. Em International Meeting of the Portuguese Society of Genetics.
Gil Martins; Laura Ribeiro; Ana Candeias-Mendes; Patrícia Diogo; Margarida Gamboa; Marisa Barata; Maria Leonor Cancela; Pedro Pousão-Ferreira; Paulo Jorge Gavaia. 2019. "Reduction of skeletal anomalies in meagre ( Argyrosomus regius , Asso, 1801) through early introduction of inert diet". Aquaculture Research, 50 (10): 2782-2792. https://doi.org/10.1111/are.14230
Fernandez, Ignacio; Fernandes, Jorge M. O.; Roberto, Vania P.; Kopp, Martina; Oliveira, Catarina; Riesco, Marta F.; Dias, Jorge; et al. 2019. "Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish". Biochimica Et Biophysica Acta-General Subjects, 1863 (1): 39-51. https://doi.org/10.1016/j.bbagen.2018.09.017
Bäck, Magnus; Aranyi, Tamas; Cancela, M. Leonor; Carracedo, Miguel; Conceição, Natércia; Leftheriotis, Georges; Macrae, Vicky; et al. 2019. "Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet". Frontiers in Cardiovascular Medicine, 5. https://doi.org/10.3389/fcvm.2018.00196
Santos, João; Mendes-Silva, Leonardo; Afonso, Vanessa; Martins, Gil; Machado, Rui; Lopes, Joao; Cancela, M. Leonor; et al. 2019. "Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants". Cell Death & Disease, 10 (8). https://doi.org/10.1038/s41419-019-1816-6
Granadeiro, Luis; Dirks, Ron P.; Ortiz-Delgado, Juan B.; Gavaia, Paulo J.; Sarasquete, Carmen; Laizé, Vincent; Cancela, M. Leonor; Fernández, Ignacio. 2019. "Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns". Ecotoxicology and Environmental Safety, 181: 559-571. https://doi.org/10.1016/j.ecoenv.2019.06.042
ML Cancela. 2019. "Intracellular iron uptake is favored in
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ML Cancela. 2019. "Anti-Osteogenic Activity of Cadmium in Zebrafish". Fishes. https://doi.org/10.3390/fishes4010011
2019. "Molecular and Functional Analysis of Mutations in the Transcription Factor ZNF687 Associated to Paget Disease of Bone". Mestrado. http://hdl.handle.net/10400.1/13585
T Gago; H Caiado; Conceição, Natércia; D Tiago; AM Vaz; S Vicente; JL Enriquez; et al. 2019. Expressão do gene MGP no Carcinoma Colorretal: Haverá relação com o CA 19.9?. Em XXXIV Reunião Anual NGHD Núcleo de Gastroenterologia dos Hospitais Distritais.
H Caiado; Conceição, Natércia; ML Cancela. 2019. Epigenetic regulation of Matrix Gla Protein gene through miR-155 in Breast Cancer. Em 3rd jornadas do Algarve Biomedical Center.
Tatiana Varela; M Vitorino; Conceição, Natércia; ML Cancela. 2019. Zebrafish as a model to study CDKL5 deficiency disorder. Em 3rd jornadas do Algarve Biomedical Center.
Conceição, Natércia; Débora Varela; Tatiana Varela; P Azevedo; S. Pereira; A Camacho; I Jesus; ML Cancela. 2019. Functional analysis of a novel TBX5 c.905delA mutation present in a Holt-Oram syndrome patient. Em 3rd Jornadas do Algarve Biomedical Center.
Conceição, Natércia; Tatiana Varela; V Laizé; ML Cancela. 2019. DUSP4 expression in colorectal cancer and insight into its transcriptional regulation. Em VIII National RNA Meeting ptRNA2019.
H Caiado; Conceição, Natércia; ML Cancela. 2019. Correlation between Matrix Gla Protein gene and microRNA 155 expression in cancer. Em VIII National RNA Meeting ptRNA2019.
Felício, Daniela; Camacho, António; ML Cancela; Simão, Márcio. 2019. Bioinformatic analysis and characterization of pathogenic mutations on HLA-B27 alleles and its putative implications on protein structure. Em 3rd Annual Meeting of the Algarve Biomedical Center (ABC).
Roberto, Vânia Palma; Martins, Gil; Dias, Jorge; Mata, Leonardo; Miguel, G.; M Leonor Cancela; Laizé, Vincent; Gavaia, P. 2019. Vitamin K role on the osteocalcin: GPRC6A axis: insights from non-mammalian models. Em European Calcified Tissue Society 2019.
Fernández, I.; Gavaia, P.J.; Laizé, V.; Cancela, M.L.. 2018. "Fish as a model to assess chemical toxicity in bone". Aquatic Toxicology, 194: 208-226. https://doi.org/10.1016/j.aquatox.2017.11.015
Roberto, Vânia Palma; Gavaia, Paulo; Nunes, Maria João; Rodrigues, Elsa; Cancela, Maria Leonor; Tiago, Daniel Martins. 2018. "Evidences for a New Role of miR-214 in Chondrogenesis". Scientific Reports, 8 (1). https://doi.org/10.1038/s41598-018-21735-w
Vitorino, Marta; Cunha, Nidia; Conceicao, Natercia; Leonor Cancela, M.. 2018. "Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome". Molecular Biology Reports, 45 (4): 445-451. https://doi.org/10.1007/s11033-018-4180-1
Fazenda, C.; Martins, G.; Gavaia, P. J.; Cancela, M. L.; Conceicao, N.. 2018. "Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein". Journal of Applied Ichthyology, 34 (2): 472-480. https://doi.org/10.1111/jai.13662
Cardeira, J.; Laize, V.; Martins, G.; Cancela, M. L.; Gavaia, P. J.. 2018. "An overview on the teleost bone mechanophysiology". Journal of Applied Ichthyology, 34 (2): 440-448. https://doi.org/10.1111/jai.13661
Carson, Matthew A.; Nelson, John; Cancela, M. Leonor; Laize, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; et al. 2018. "Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum". Plos One, 13 (11). https://doi.org/10.1371/journal.pone.0207303
Eckhard Witten, P.; Leonor Cancela, M.. 2018. "What aquaculture does for taxonomy, evo-devo, palaeontology, biomechanics and biomedical research". Journal of Applied Ichthyology, 34 (2): 429-430. https://doi.org/10.1111/jai.13670
Vitorino, M.; Conceicao, N.; Cancela, M. L.; Conceição, N.. 2018. "Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome". Journal of Applied Ichthyology, 34 (2): 489-500. https://doi.org/10.1111/jai.13667
Silva, Iris A. L.; Conceiceao, Natercia; Gagnon, Edith; Brown, Jacques P.; Cancela, M. Leonor; Michou, Laetitia. 2018. "Molecular effect of an OPTN common variant associated to Paget's disease of bone". Plos One, 13 (5). https://doi.org/10.1371/journal.pone.0197543
Ferreira-Rodriguez, Noe; Fernandez, Ignacio; Leonor Cancela, M.; Pardo, Isabel. 2018. "Multibiomarker response shows how native and non-native freshwater bivalves differentially cope with heat-wave events". Aquatic Conservation-Marine and Freshwater Ecosystems, 28 (4): 934-943. https://doi.org/10.1002/aqc.2884
Laize, Vincent; Gavaia, Paulo J.; Tarasco, Marco; Viegas, Michael N.; Caria, Joana; Luis, Nuno; Leonor Cancela, M.. 2018. "Osteotoxicity of 3-methylcholanthrene in fish". Ecotoxicology and Environmental Safety, 161: 721-728. https://doi.org/10.1016/j.ecoenv.2018.06.035
Carson, Matthew A.; Nelson, John; Cancela, M. Leonor; Laize, Vincent; Gavaia, Paulo J.; Rae, Margaret; Heesch, Svenja; et al. 2018. "Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae". Scientific Reports, 8. https://doi.org/10.1038/s41598-018-26024-0
Rosa, Joana; Cox, Cymon J.; Leonor Cancela, M.; Laize, Vincent. 2018. "Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism". Gene, 645: 137-145. https://doi.org/10.1016/j.gene.2017.12.021
Roberto, V. P.; Martins, G.; Pereira, A.; Rodrigues, S.; Grenha, A.; Pinto, W.; Cancela, M. L.; Dias, J.; Gavaia, P. J.. 2018. "Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers". Journal of Applied Ichthyology, 34 (2): 512-523. https://doi.org/10.1111/jai.13664
Simao, Marcio; Camacho, Antonio; Cohen-Solal, Martine; Jorge Pinto, I.; Porto, Graca; Korng, Ea Hang; Leonor Cancela, M.. 2018. "Iron enriched diet in association with Hfe loss of function promote iron toxicity mechanism and accelerate bone loss phenotype". Free Radical Biology and Medicine, 120: S148-S148. https://doi.org/10.1016/j.freeradbiomed.2018.04.489
Simao, Marcio; Camacho, Antonio; Ostertag, Agnes; Cohen-Solal, Martine; Jorge Pinto, I.; Porto, Graca; Korng, Ea Hang; Leonor Cancela, M.. 2018. "Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis". Plos One, 13 (11). https://doi.org/10.1371/journal.pone.0207441
Silva, Iris A. L.; Conceição, Natércia; Gagnon, Edith; Caiado, Helena; Brown, Jacques P.; Gianfrancesco, Fernando; Michou, Laëtitia; et al. 2018. "Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone". Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (1): 143-151. https://doi.org/10.1016/j.bbadis.2017.10.008
Franco, Hannah Sabrina. 2018. "CRISPR: applications in human pathologies and future prospects". Mestrado. http://hdl.handle.net/10400.1/12618
Carvalho, Filipe R.; Calado, Sofia M.; Silva, Gabriela A.; Diogo, Gabriela S.; Moreira da Silva, Joana; Reis, Rui L.; Cancela, M. Leonor; Gavaia, Paulo J.. 2018. "Altered bone microarchitecture in a type 1 diabetes mouse model
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Akita". Journal of Cellular Physiology, 234 (6): 9338-9350. https://doi.org/10.1002/jcp.27617
G Sequeira; P Carvalho; C Ribeiro; AS Alfaia; Conceição, Natércia; ML Cancela. 2018. Characterization of Paget´s Disease of Bone Patients from the South of Portugal (Algarve and Alentejo) – Clinical and Genetic Aspects . Em ACR/ARHP Annual Meeting.
FAZENDA, CINDY; Martins, Gil; Gavaia, Paulo; Leonor Cancela; Conceição, Natércia. 2018. "Generation and characterization of zebrafish transgenic lines overexpressing a heat-shock mediated Gla-rich protein". Journal of Applied Ichthyology. https://doi.org/10.1111/JAI.13662
H Caiado; R Reis; T Authier; ML Cancela; Conceição, Natércia. 2018. Analysis of ZNF687 gene expression in different tumors using the cancer genome atlas database. Em Annual Meeting 2018 Portuguese Society of Genetics.
Conceição, Natércia; H Caiado; A Marreiros; ML Cancela. 2018. Regulation of the Matrix Gla Protein through epigenetic mechanisms. Em Annual Meeting 2018 Portuguese Society of Genetics.
S Serrano; T Authier; ML Cancela; Conceição, Natércia. 2018. Análise das regiões promotoras dos genes znf687a e znf687b do peixe-zebra (Danio rerio). Em Aniversário do curso de bioquímica.
R arroja; T Authier; Conceição, Natércia; ML Cancela. 2018. Estudo da análise do promotor do gene ZNF687 humano e identificação de fatores de transcrição. Em Aniversário do curso de bioquímica.
T Authier; S Serrano; AR Pinho; ML Cancela; Conceição, Natércia. 2018. Study of transcriptional regulation of zebrafish orthologues of human ZNF687 gene. Em Interdisciplinary Approaches in Fish Skeletal Biology, 5th Conference.
W Zhang; HG Silva; C Viana; PJS Duarte; E Veiga; B Bica; I de Matos; et al. 2018. Zebrafish as a model to study PHYH related pathologies. Em Interdisciplinary Approaches in Fish Skeletal Biology, 5th Conference.
Tatiana Varela; Conceição, Natércia; V Laizé; P Caldeira; A Marreiros; H Guerreiro; ML Cancela. 2018. DUSP4 transcripts expression as a potential biomarker for colorectal cancer. Em 2nd jornadas do Algarve Biomedical Center.
Conceição, Natércia; Débora Varela; A Ferreira; N. Marques; AP Silva; ML Cancela. 2018. Functional analysis of a novel TBX5 c.246_249delGATG mutation present in a Holt-Oram syndrome patient. Em , 2nd jornadas do Algarve Biomedical Center.
Conceição, Natércia; H Caiado; D Tiago; A Marreiros; AM Vaz; S Vicente; H Guerreiro; P Caldeira; ML Cancela. 2018. MGP overexpression is associated with a worse prognosis and survival outcome in colorectal adenocarcinomas. Em 2nd jornadas do Algarve Biomedical Center.
I Bodião; ML Cancela; Conceição, Natércia. 2018. On using Feature Descriptors asScreening for detection of SNPs within the PDB6 locus associated with Paget disease of bone. Em 4th MEEting of MIM. https://doi.org/10.1049/ic.2016.0080
Marques, C.; Roberto, V.P.; Granadeiro, L.; Trindade, M.; Gavaia, P.J.; Laizé, V.; Cancela, M.L.; Fernández, I.. 2017. "The xenobiotic sensor PXR in a marine flatfish species (Solea senegalensis): Gene expression patterns and its regulation under different physiological conditions". Marine Environmental Research, 130: 187-199. https://doi.org/10.1016/j.marenvres.2017.07.021
Saavedra, Carlos; Milan, Massimo; Leite, Ricardo B.; Cordero, David; Patarnello, Tomaso; Cancela, M. Leonor; Bargelloni, Luca. 2017. "A Microarray Study of Carpet-Shell Clam (Ruditapes decussatus) Shows Common and Organ-Specific Growth-Related Gene Expression Differences in Gills and Digestive Gland". Frontiers in Physiology, 8. https://doi.org/10.3389/fphys.2017.00943
Surget, G.; Roberto, V.P.; Le Lann, K.; Mira, S.; Guérard, F.; Laizé, V.; Poupart, N.; Cancela, M.L.; Stiger-Pouvreau, V.. 2017. "Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities". Journal of Applied Phycology, 29 (1): 575-584. https://doi.org/10.1007/s10811-016-0968-3
Carvalho, Filipe R.; Fernandes, Ana R.; Cancela, M. Leonor; Gavaia, Paulo J.. 2017. "Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with paricalcitol and cinacalcet". Wound Repair and Regeneration, 25 (3): 432-442. https://doi.org/10.1111/wrr.12536
Ferreira-Rodríguez, N.; Fernández, I.; Varandas, S.; Cortes, R.; Cancela, M.L.; Pardo, I.. 2017. "The role of calcium concentration in the invasive capacity of Corbicula fluminea in crystalline basins". Science of the Total Environment, 580: 1363-1370. https://doi.org/10.1016/j.scitotenv.2016.12.100
Tarasco, M.; Laizé, V.; Cardeira, J.; Cancela, M.L.; Gavaia, P.J.. 2017. "The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance". Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 197: 45-52. https://doi.org/10.1016/j.cbpc.2017.04.006
Varela, Débora Cristina Domingos. 2017. "Genetic and functional analysis of specific TBX5 mutations associated with Holt-Oram Syndrome". Mestrado. http://hdl.handle.net/10400.1/10470
Simão, Márcio Alexandre Filipe. 2017. "Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with hereditary hemochromatosis". Doutoramento. http://hdl.handle.net/10400.1/10812
Saavedra, C.; Milan, M.; Cordero, D.; Leite, R.; Pena, J. B.; Delgado, M.; Liu, B.; et al. 2017. "Population genetics and transcriptomics of Manila Clam (Ruditapes philippinarum) and carpet-shell clam (R. decussatus): implications for aquaculture".
T Authier; Conceição, Natércia; ML Cancela. 2017. Comparative analysis of the zinc finger protein ZNF687 throughout evolution. Em X Encontro Nacional de Biologia Evolutiva.
ML Cancela; Débora Varela; Conceição, Natércia. 2017. Initial validation of zebrafish as model for Holt-Oram syndrome. Em FishBone 2017 ECTS 2017 Pre-congress.
Tiago, D.M.; Conceição, N.; Caiado, H.; Laizé, V.; Cancela, M.L.. 2016. "Matrix Gla protein repression by MIR-155 promotes oncogenic signals in breast cancer MCF-7 cells". FEBS Letters, 590 (8): 1234-1241. https://doi.org/10.1002/1873-3468.12155
Rosa, J.; Tiago, D.M.; Marques, C.L.; Vijayakumar, P.; Fonseca, L.; Cancela, M.L.; Laizé, V.; et al. 2016. "Central role of betaine-homocysteine S-methyltransferase 3 in chondral ossification and evidence for sub-functionalization in neoteleost fish". Biochimica et Biophysica Acta - General Subjects, 1860 (7): 1373-1387. https://doi.org/10.1016/j.bbagen.2016.03.034
Marques, C.L.; Fernández, I.; Viegas, M.N.; Cox, C.J.; Martel, P.; Rosa, J.; Cancela, M.L.; Laizé, V.. 2016. "Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: Molecular and evolutionary perspectives". Cellular and Molecular Life Sciences, 73 (4): 841-857. https://doi.org/10.1007/s00018-015-2024-x
Roberto, V.P.; Tiago, D.M.; Gautvik, K.; Cancela, M.L.. 2016. "Corrigendum to "Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function" [Gene 566/1 (2015) 54-62], doi: 10.1016/j.gene.2015.04.022". Gene, 576 (1). https://doi.org/10.1016/j.gene.2015.10.001
Correia, E.; Conceição, N.; Cancela, M.L.; Belo, J.A.. 2016. "Matrix Gla protein expression pattern in the early avian embryo". International Journal of Developmental Biology, 60 (1-3): 71-76. https://doi.org/10.1387/ijdb.150365jb
Adrião, A.; Conceição, N.; Cancela, M.L.; Adrião, Andreia Lúcia Gonçalves; Conceição, Natércia; Cancela, Leonor. 2016. "MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation". Archives of Biochemistry and Biophysics, 591: 43-56. https://doi.org/10.1016/j.abb.2015.12.004
Bensimon-Brito, A.; Cardeira, J.; Dionísio, G.; Huysseune, A.; Cancela, M.L.; Witten, P.E.. 2016. "Revisiting in vivo staining with alizarin red S - A valuable approach to analyse zebrafish skeletal mineralization during development and regeneration". BMC Developmental Biology, 16 (1). https://doi.org/10.1186/s12861-016-0102-4
Medeiros, M.C.R.; Mestre, A.; Inácio, P.; Asgarif, S.; Araújo, I.M.; Hubbard, P.C.; Velez, Z.; et al. 2016. "An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes". Sensing and Bio-Sensing Research, 10: 1-8. https://doi.org/10.1016/j.sbsr.2016.06.002
Marques, C.L.; Cancela, M.L.; Laizé, V.. 2016. "Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors". Gene, 576 (1): 229-236. https://doi.org/10.1016/j.gene.2015.10.005
Cardeira, J.; Gavaia, P.J.; Fernández, I.; Cengiz, I.F.; Moreira-Silva, J.; Oliveira, J.M.; Reis, R.L.; Cancela, M.L.; Laizé, V.. 2016. "Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin". Scientific Reports, 6. https://doi.org/10.1038/srep39191
Cancela, Maria Leonor; Branco, Jaime da Cunha; Camacho, António Manuel Mendonça Romão de Brito. 2016. "Characterization of the clinical, histological and genetic profile of articular damage in hereditary hemochromatosis". Doutoramento. http://hdl.handle.net/10362/19226
Silva, Inês Martins. 2016. "Contribuição para a identificação do papel da MGP no desenvolvimento tumoral no cancro colorretal". Mestrado. http://hdl.handle.net/10400.1/9899
Carvalho, Filipe Ricardo Pires de. 2016. "Characterization of bone pathologies in the ins2+/akita mouse, a new model for diabetes insulindependent: contribution for a better understanding of the disease in humans". Doutoramento. http://hdl.handle.net/10400.1/8680
Tarasco, Marco. 2016. "Screening natural resources for mineralogenic and osteogenic bioactivities using in vitro and in vivo fish systems". Mestrado. http://hdl.handle.net/10400.1/8653
Danielsen, Steffen ; Lars Kobberoee Skov; Leite, Ricardo B; Laizé, V; Leonor Cancela. 2016. "Dfpase enzymes from aplysia californica". Concedida/Emitida.
Silva, I. A. L.; Michou, L.; Cancela, M. Leonor; Conceição, Natércia; Cancela, M. L.; Conceicao, N.. 2016. "Functional study of OPTN promoter: new OPTN regulators and effect of genetic variants". European Journal of Clinical Investigation, 46: 124-124. http://hdl.handle.net/10400.1/9534
Vitorino, M.; Conceicao, N.; Adrião, Andreia Lúcia Gonçalves; Cancela, M. Leonor; Adriao, A.; Cancela, M. L.. 2016. "Zebrafish as a disease model for studying human Rett Syndrome". http://hdl.handle.net/10400.1/9535
Shapouri, M.; Cancela, Leonor; Iepure, S.; Stigter, T.; Ribeiro, L.; Silva, A.. 2016. "The variation of stygofauna along a gradient of salinization in a coastal aquifer". https://doi.org/10.2166/nh.2015.153
Diogo, Patricia; Eufrásio, Ana; Martins, Gil; Cardeira, João; Cancela, M. Leonor; Cabrita, Elsa; Gavaia, Paulo. 2016. "Analysis of sperm quality in a type I diabetes zebrafish model". http://hdl.handle.net/10400.1/9252
Camacho, A.; F. Simao, Marcio; Ea, H. -K.; Cohen-Solal, M.; Richette, P.; Branco, J.; Cancela, Leonor; et al. 2016. "Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress". Osteoarthritis and Cartilage, 24 (3): 494-502. https://doi.org/10.1016/j.joca.2015.09.007
Divisato, Giuseppina; Formicola, Daniela; Esposito, Teresa; Merlotti, Daniela; Pazzaglia, Laura; Del Fattore, Andrea; Siris, Ethel; et al. 2016. "ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor". American Journal of Human Genetics, 98 (2): 275-286. https://doi.org/10.1016/j.ajhg.2015.12.016
M Leonor Cancela; Laizé, V.; Danielsen, Steffen ; Skov LK; Leite, Ricardo B. 2016. "DFPase enzymes from Aplysia Californica". Dinamarca. Concedida/Emitida.
AS Sofia; S Mariano; Tatiana Varela; JJ Matos; D Varela; T Authier; ML Cancela; Conceição, Natércia. 2016. Bioinformatic Analysis of CCDC3 gene: A Potential Contributor for Paget Disease of Bone?. Em XL Jornadas Portuguesas de Genética.
M Vitorino; Conceição, Natércia; ML Cancela. 2016. Zebrafish as model for bone diseases associated with Rett syndrome. Em XL Jornadas Portuguesas de Genética.
C Fazenda; M Vitorino; A Cachucho; L Shu-Wha; PJ Gavaia; Conceição, Natércia; ML Cancela. 2016. Gla-rich protein deficient mice born from homozygous mutant progenitors show cartilage and bone defects. Em XL Jornadas Portuguesas de Genética.
VP Roberto; Conceição, Natércia; MJ Nunes; E. Rodrigues; ML Cancela; DM Tiago. 2016. miR-214: A Novel Regulator of Chondrogenesis?. Em ECST2016.
IAL Silva; Conceição, Natércia; L Michou; ML Cancela. 2016. Comparative analysis of human and zebrafish OPTN: molecular and evolutionary perspectives. Em ECST2016.
IAL Silva; Conceição, Natércia; ML Cancela. 2016. OPTN and CCDC3 share a bidirectional promoter region that is regulated by NF-kB. Em ECSC2016.
Diogo, Patricia; Eufrásio, Ana; Martins, Gil; Cardeira-da-Silva, João; M Leonor Cancela; Cabrita, Elsa; Gavaia, P. 2016. Diabetic zebrafish (Danio rerio) sperm quality and cryopreservation. Em 20th Annual European Society for Domestic Animal Reproduction - ESDAR Conference.
Camacho, A.; Funck-Brentano, T.; Simão, M.; Cancela, L.; Ottaviani, S.; Cohen-Solal, M.; Richette, P.. 2015. "Effect of C282Y genotype on self-reported musculoskeletal complications in hereditary hemochromatosis". PLoS ONE, 10 (3). https://doi.org/10.1371/journal.pone.0122817
Simões, B.; Conceição, N.; Matias, A.C.; Bragança, J.; Kelsh, R.N.; Cancela, M.L.. 2015. "Molecular characterization of cbfß gene and identification of new transcription variants: Implications for function". Archives of Biochemistry and Biophysics, 567: 1-12. https://doi.org/10.1016/j.abb.2014.12.023
Diogo, P.; Martins, G.; Gavaia, P.; Pinto, W.; Dias, J.; Cancela, L.; Martínez-Páramo, S.. 2015. "Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822)". Journal of Applied Ichthyology, 31 (S1): 3-9. https://doi.org/10.1111/jai.12733
Rodrigues, E.T.; Pardal, M.Â.; Laizé, V.; Cancela, M.L.; Oliveira, P.J.; Serafim, T.L.. 2015. "Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin". Environmental Pollution, 206: 619-626. https://doi.org/10.1016/j.envpol.2015.08.026
Cardeira, J.; Mendes, A.C.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2015. "Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis". Journal of Fish Biology, 86 (6): 1796-1810. https://doi.org/10.1111/jfb.12686
Roberto, V.P.; Tiago, D.M.; Gautvik, K.; Cancela, M.L.. 2015. "Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function". Gene, 566 (1): 54-62. https://doi.org/10.1016/j.gene.2015.04.022
Fernández, I.; Vijayakumar, P.; Marques, C.; Cancela, M.L.; Gavaia, P.J.; Laizé, V.. 2015. "Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure". Fish Physiology and Biochemistry, 41 (3): 745-759. https://doi.org/10.1007/s10695-015-0043-z
Fazenda, C.; Conceição, N.; Cancela, M.L.. 2015. "Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene". Gene, 572 (1): 57-62. https://doi.org/10.1016/j.gene.2015.06.079
Hill, Billy Samuel. 2015. "Drug repurposing in the treatment of Melanoma Brain Metastasis". Mestrado. http://hdl.handle.net/10400.1/8219
Silva, Iris Alexandra Lopes da. 2015. "Genetic and functional analysis of the PDB6 locus in Paget's disease of bone". Doutoramento. http://hdl.handle.net/10400.1/7669
Rosa, Joana Alexandra Teixeira. 2015. "Identification of novel molecular determinants of tissue mineralization in fish". Doutoramento. http://hdl.handle.net/10400.1/8756
Adrião, Andreia Lúcia Gonçalves. 2015. "MEF2C: expression, regulation and interaction with target genes in health and diseases". Doutoramento. http://hdl.handle.net/10400.1/8751
Anastácio, Fábio Miguel Vicente. 2015. "Estudo do papel desempenhado pela proteína anexina A2 na regulação de vias de transdução de sinal ativadas por Ras". Mestrado. http://hdl.handle.net/10400.1/7870
Leonor Cancela; Conceição, Natércia; Tiago, Daniel. 2015. "Utilização da MGP como método de diagnóstico, prognostico e alvo terapêutico no cancro". Expirada.
D Marques; Conceição, Natércia; ML Cancela. 2015. Paget’s disease of bone: contribution to the study of human locus PDB6. Em 1st MEEting of MIM.
JC Nogueira; Conceição, Natércia; ML Cancela. 2015. MRD20 or Mental Retardation Autosomal Dominant: contribution to the study of a recently identified human mutation. Em 1st MEEting of MIM.
IAL Silva; Conceição, Natércia; L Michou; ML Cancela. 2015. Zebrafish as an animal model to study OPTN role in Paget´s disease of bone. Em Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference.
Conceição, Natércia; A Adrião; M Grazina; ML Cancela. 2015. Towards validation of zebrafish as a model to study MEF2C related pathologies. Em Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference. https://doi.org/10.1109/icstw.2016.7
M Vitorino; Conceição, Natércia; A Adrião; ML Cancela. 2015. Zebrafish as a model to study bone diseases associated with Rett syndrome. Em Interdisciplinary Approaches in Fish Skeletal Biology, 4th Conference.
Conceição, Natércia; Fazenda, Cindy; Martins, Gil; Gavaia, P; M Leonor Cancela. 2015. Study of transcriptional regulation and function of Gla rich protein gene in zebrafish. Em 9th European Zebrafish Meeting.
Gavaia, P; Pereira, Alexandra; Grenha, Ana; Martins, Gil; Conceição, Luis E. C.; Rodrigues, Vera; Pinto, Wilson; M Leonor Cancela; Dias, Jorge. 2015. Dietary supplementation with strontium citrate positively affects the osteological development of zebrafish (Danio rerio) larvae. Em 9th European Zebrafish Meeting.
Fazenda, Cindy; Martins, Gil; Gavaia, P; M Leonor Cancela; Conceição, Natércia. 2015. Establishment of transgenic zebrafish lines capable of conditionally inducing expression of Gla-rich protein. Em IV Interdisciplinary Approaches in Fish Skeletal Biology.
Gavaia, P; Martins, Gil; Livramento, Marcelo ; Laizé, Vincent; M Leonor Cancela; Dias, Jorge. 2015. Effects of dietary zinc supplementation on zebrafish larvae osteological development. Em IV Interdisciplinary Approaches in Fish Skeletal Biology.
Pereira, Alexandra; Martins, Gil; Pinto, Wilson; Conceição, Luis E. C.; Dias, Jorge; M Leonor Cancela; Gavaia, P. 2015. Effects of dietary supplementation with strontium nitrate on the osteological development of zebrafish (Danio rerio) larvae. Em IV Interdisciplinary Approaches in Fish Skeletal Biology.
Witten, P.E.; Cancela, M.L.. 2014. "Fish skeletal biology and beyond". Journal of Applied Ichthyology, 30 (4): 597-599. https://doi.org/10.1111/jai.12506
Simões, B.; Conceição, N.; Kelsh, R.N.; Cancela, M.L.. 2014. "Identification of cis-regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: Implications for function". Journal of Applied Ichthyology, 30 (4): 661-670. https://doi.org/10.1111/jai.12536
Cancela, M.L.; Laizé, V.; Conceição, N.. 2014. "Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization". Archives of Biochemistry and Biophysics, 561: 56-63. https://doi.org/10.1016/j.abb.2014.07.020
Tiago, D.M.; Marques, C.L.; Roberto, V.P.; Cancela, M.L.; Laizé, V.. 2014. "Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish". Archives of Biochemistry and Biophysics, 543: 23-30. https://doi.org/10.1016/j.abb.2013.12.009
Silva, I.A.L.; Conceição, N.; Michou, L.; Cancela, M.L.. 2014. "Can zebrafish be a valid model to study Paget's disease of bone?". Journal of Applied Ichthyology, 30 (4): 678-688. https://doi.org/10.1111/jai.12523
Rosa, J.T.; Cancela, M.L.; Laizé, V.. 2014. "Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream". Journal of Applied Ichthyology, 30 (4): 707-712. https://doi.org/10.1111/jai.12534
Silva, I.A.L.; Cox, C.J.; Leite, R.B.; Cancela, M.L.; Conceição, N.. 2014. "Evolutionary conservation of TFIIH subunits: Implications for the use of zebrafish as a model to study TFIIH function and regulation". Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology, 172-173 (1): 9-20. https://doi.org/10.1016/j.cbpb.2014.03.007
Roberto, V.P.; Tiago, D.M.; Silva, I.A.; Cancela, M.L.. 2014. "MiR-29a is an enhancer of mineral deposition in bone-derived systems". Archives of biochemistry and biophysics, 564: 173-183. https://doi.org/10.1016/j.abb.2014.09.006
Marques, C.L.; Fernández, I.; Rosa, J.; Viegas, M.N.; Cancela, M.L.; Laizé, V.. 2014. "Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole". Journal of Applied Ichthyology, 30 (4): 713-720. https://doi.org/10.1111/jai.12539
Fernández, I.; Santos, A.; Cancela, M.L.; Laizé, V.; Gavaia, P.J.. 2014. "Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and ¿-glutamyl carboxylation of vitamin K-dependent proteins". Environmental Pollution, 194: 86-95. https://doi.org/10.1016/j.envpol.2014.07.015
Richard, N.; Fernández, I.; Wulff, T.; Hamre, K.; Cancela, L.; Conceição, L.E.C.; Gavaia, P.J.. 2014. "Dietary Supplementation with Vitamin K Affects Transcriptome and Proteome of Senegalese Sole, Improving Larval Performance and Quality". Marine Biotechnology, 16 (5): 522-537. https://doi.org/10.1007/s10126-014-9571-2
Laizé, V.; Gavaia, P.J.; Cancela, M.L.. 2014. "Fish: A suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities". Drug Discovery Today: Disease Models, 13: 29-37. https://doi.org/10.1016/j.ddmod.2014.08.001
Cavaco, S.; Williamson, M.K.; Rosa, J.; Roberto, V.; Cordeiro, O.; Price, P.A.; Leonor Cancela, M.; et al. 2014. "Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase". Fish Physiology and Biochemistry, 40 (3): 731-738. https://doi.org/10.1007/s10695-013-9880-9
Fernández, I.; Tiago, D.M.; Laizé, V.; Leonor Cancela, M.; Gisbert, E.. 2014. "Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins". Journal of Steroid Biochemistry and Molecular Biology, 140: 34-43. https://doi.org/10.1016/j.jsbmb.2013.11.012
Rodrigues, Brigite Sandra Nunes Simões. 2014. "Molecular structure and functional analysis of runx3 in zebrafish". Doutoramento. http://hdl.handle.net/10400.1/6851
Roberto, V.. 2014. "Identification and molecular characterization of bone-related micrornas: functional implications". Doutoramento. http://hdl.handle.net/10400.1/7080
Fazenda, Cindy Vitória. 2014. "Molecular characterization of Gla-rich protein (GRP) gene expression and function". Doutoramento. http://hdl.handle.net/10400.1/6842
Gavaia, P; Bretes, Francisco; Martins, Gil; Conceição, Luis E. C.; Pinto, Wilson; M Leonor Cancela; Dias, Jorge. 2014. Osteological and developmental effects of dietary zinc supplementation in zebrafish larvae. Em Aquaculture Europe 2014.
IAL Silva; Conceição, Natércia; L Michou; ML Cancela. 2014. Functional study of Optineurin (OPTN) variants associated with Paget’s disease of bone. Em ASBMR.
IAL Silva; Conceição, Natércia; L Michou; ML Cancela. 2014. Functional analysis of a promoter polymorphism of Optineurin, a gene to associated to Paget’s Disease of Bone. Em ECTS2014.
FAZENDA, CINDY; Conceição, Natércia; Leonor Cancela. 2014. "Trancription factors from Sox family regulate zebrafish Gla-rich protein 2 gene". https://doi.org/10.1111/febs.12919
C Fazenda; Conceição, Natércia; ML Cancela. 2014. Transcription factors from Sox family regulate zebrafish Gla-rich protein 2 gene. Em YSF FEBS2014.
Vijayakumar, P.; Laizé, V.; Cardeira, J.; Trindade, M.; Cancela, M.L.. 2013. "Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization". Zebrafish, 10 (4): 500-509. https://doi.org/10.1089/zeb.2012.0833
Mira, S.; Arnaud-Haond, S.; Palma, L.; Cancela, M.L.; Beja, P.. 2013. "Large-scale population genetic structure in Bonelli's Eagle Aquila fasciata". Ibis, 155 (3): 485-498. https://doi.org/10.1111/ibi.12065
Leite, R.B.; Milan, M.; Coppe, A.; Bortoluzzi, S.; dos Anjos, A.; Reinhardt, R.; Saavedra, C.; et al. 2013. "MRNA-Seq and microarray development for the Grooved carpet shell clam, Ruditapes decussatus: A functional approach to unravel host -parasite interaction". BMC Genomics, 14 (1). https://doi.org/10.1186/1471-2164-14-741
Conceição, N.; Viegas, M.; Fidalgo, J.; Cancela, M.L.. 2013. "Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture". Molecular and Cellular Biochemistry, 373 (1-2): 41-51. https://doi.org/10.1007/s11010-012-1473-x
Viegas, C.S.B.; Simes, D.C.; Williamson, M.K.; Cavaco, S.; Laizé, V.; Price, P.A.; Cancela, M.L.. 2013. "Sturgeon osteocalcin shares structural features with matrix Gla protein: Evolutionary relationship and functional implications". Journal of Biological Chemistry, 288 (39): 27801-27811. https://doi.org/10.1074/jbc.M113.450213
Adriao, A.; Conceicao, N.; Gavaia, P. J.; Cancela, M. L.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. 2013. "Zebrafish as a model to study craniofacial phenotypes related to human MEF2Cmutations". European Journal of Clinical Investigation, 43: 102-102. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000294&KeyUID=WOS:000317141000294
Silva, I. A. L.; Conceicao, N.; Michou, L.; Cancela, M. L.. 2013. "Genetic variation in pdb6 locus and Paget's disease of bone". European Journal of Clinical Investigation, 43: 81-81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317141000235&KeyUID=WOS:000317141000235
Marques, Cátia Andreia Lourenço. 2013. "Evolution, gene regulation and functional analysis of BMP2 in fish". Doutoramento. http://hdl.handle.net/10400.1/6751
Schnorr, KM; Leonor Cancela; Leite, Ricardo B; Anderson L. 2013. "Polypeptides having cellulose activity and polynucleotides encoding same". Concedida/Emitida.
Araujo, Nuna C. P.; Afonso, Ricardo; Bringela, A.; Cancela, Leonor; Cristiano, Maria Lurdes Santos; Leite, Ricardo; Araujo, N.C.P.; et al. 2013. "Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves". Parasitology International, 62 (6): 575-582. https://doi.org/10.1016/j.parint.2013.06.010
Conceição, Natércia; B Simões; ML Cancela. 2013. "Functional analysis of the two Runx3 promoters in osseous and non-osseous cells: implications for tissue/differentiation speci¿c transcription of distinct isoforms.". Trabalho apresentado em Bone Abstracts .
IAL Silva; Conceição, Natércia; L Michou; ML Cancela. 2013. Single nucleotide polymorphisms identification and functional analysis in PDB6 locus – A target locus for Paget’s Disease of Bone. Em ECTS2013.
Conceição, Natércia; A Adrião; ML Cancela. 2013. Identification of two functional promoters for zebrafish mef2cb gene. Em 8th European Zebrafish Meeting.
Conceição, Natércia; B Simões; ML Cancela. 2013. Functional analysis of the two Runx3 promoters in osseous and non-osseous cells: implications for tissue/differentiation specific transcription of distinct isoforms. Em ECST2013.
C Fazenda; Conceição, Natércia; ML Cancela. 2013. Transcriptional regulation of the zebrafish Gla-rich protein 2 (grp2) gene. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.
A Adrião; PJ Gavaia; Conceição, Natércia; ML Cancela. 2013. Use of reporter lines to visualize bone and cartilage phenotypes in the zebrafish mef2cab1086 mutant line. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.
Marcio Simao; Paulo Gavaia; Jorge Pinto; Ea Korng; M Leonor Cancela; Simao, Marcio; Gavaia, Paulo; et al. 2013. "Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism". BA. https://doi.org/10.1530/boneabs.1.pp262
Conceição, N.; Fazenda, C.; Cancela, M.L.. 2012. "Comparative gene promoter analysis: An in silico strategy to identify candidate regulatory factors for Gla Rich Protein". Journal of Applied Ichthyology, 28 (3): 372-376. https://doi.org/10.1111/j.1439-0426.2012.02001.x
Cardeira, J.; Bensimon-Brito, A.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2012. "Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis)". Journal of Applied Ichthyology, 28 (3): 460-463. https://doi.org/10.1111/j.1439-0426.2012.01978.x
Fazenda, C.; Silva, I.A.L.; Cancela, M.L.; Conceição, N.. 2012. "Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish". Journal of Applied Ichthyology, 28 (3): 377-381. https://doi.org/10.1111/j.1439-0426.2012.02004.x
Silva, I.A.L.; Cancela, M.L.; Conceição, N.. 2012. "Molecular cloning and expression analysis of XPD from zebrafish (Danio rerio)". Molecular Biology Reports, 39 (5): 5339-5348. https://doi.org/10.1007/s11033-011-1333-x
Cardeira, J.; Vallés, R.; Dionísio, G.; Estévez, A.; Gisbert, E.; Pousão-Ferreira, P.; Cancela, M.L.; Gavaia, P.J.. 2012. "Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities". Journal of Applied Ichthyology, 28 (3): 464-470. https://doi.org/10.1111/j.1439-0426.2012.01979.x
Bensimon-Brito, A.; Cardeira, J.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2012. "Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation". BMC Developmental Biology, 12. https://doi.org/10.1186/1471-213X-12-28
Dionísio, G.; Campos, C.; Valente, L.M.P.; Conceição, L.E.C.; Cancela, M.L.; Gavaia, P.J.. 2012. "Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis". Journal of Applied Ichthyology, 28 (3): 471-476. https://doi.org/10.1111/j.1439-0426.2012.01996.x
Rafael, M.S.; Laizé, V.; Bensimon-Brito, A.; Leite, R.B.; Schüle, R.; Cancela, M.L.. 2012. "Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata". Cellular and Molecular Life Sciences, 69 (3): 423-434. https://doi.org/10.1007/s00018-011-0754-y
Michou, L.; Conceição, N.; Morissette, J.; Gagnon, E.; Miltenberger-Miltenyi, G.; Siris, E.S.; Brown, J.P.; Cancela, M.L.. 2012. "Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone". Bone, 51 (4): 720-728. https://doi.org/10.1016/j.bone.2012.06.028
Rafael, M.S.; Laizé, V.; Florindo, C.; Ferraresso, S.; Bargelloni, L.; Cancela, M.L.. 2012. "Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts". Biochimie, 94 (5): 1128-1134. https://doi.org/10.1016/j.biochi.2012.01.013
Viegas, M.N.; Dias, J.; Cancela, M.L.; Laizé, V.. 2012. "Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line". Journal of Applied Ichthyology, 28 (3): 427-432. https://doi.org/10.1111/j.1439-0426.2012.01994.x
Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2012. "Vestiges, rudiments and fusion events: The zebrafish caudal fin endoskeleton in an evo-devo perspective". Evolution and Development, 14 (1): 116-127. https://doi.org/10.1111/j.1525-142X.2011.00526.x
Rosa, J. T.; Cancela, M. L.; Laize, V.. 2012. "Identification of novel molecular determinants of tissue mineralization in fish". Febs Journal, 279: 538-539. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000308128602753&KeyUID=WOS:000308128602753
Parameswaran, V.; Laizé, V.; Gavaia, P.J.; Leonor Cancela, M.. 2012. "ESSA1 embryonic stem like cells from gilthead seabream: A new tool to study mesenchymal cell lineage differentiation in fish". Differentiation, 84 (3): 240-251. https://doi.org/10.1016/j.diff.2012.07.004
Leonor Cancela, M.; Conceição, N.; Laizé, V.; Cancela, M. L.; Conceicao, N.; Laize, V.. 2012. "Gla-rich protein, a new player in tissue calcification?". Advances in Nutrition, 3 (2): 174-181. https://doi.org/10.3945/an.111.001685
Eckhard Witten, P.; Leonor Cancela, M.. 2012. "Interdisciplinary approaches in fish skeletal biology". Journal of Applied Ichthyology, 28 (3): 297-299. https://doi.org/10.1111/j.1439-0426.2012.02015.x
Fonseca, Maria Leonor Quintais Cancela da; Fonseca, Luís Daniel Salsinha. 2012. "Spatio-temporal gene expression and evolutionary relationship of seabream betainehomocysteine S-methyltransferases". Mestrado. http://hdl.handle.net/10400.1/10516
Dias, J.; Colen, Rita; Rodrigues, V.; Aragão, C.; Engrola, S.; Viegas, Michel; Laizé, Vincent; Gavaia, Paulo J.; Cancela, Leonor. 2012. "Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles". Em Effect of variable levels of dietary cholesterol and plant sterols on the growth performance and bone metabolism in gilthead seabream (Sparus aurata) juveniles. Noruega: National Institute of Nutrition and Seafood Research; Norwegian University of Life Sciences; Aquaculture Protein Centre; Norwegian School of Veterinary Science; Nofima.
Fernández, Ignacio; Cancela, Leonor; Gavaia, Paulo J.. 2012. "Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.". Em Temporal and spatial expression patterns of pregnane X receptor and vitamin K epoxide reductase genes, two core molecular players on fish vitamin K homeostasis and skeletal development.. prague, República Checa: European Aquaculture Society; World Aquaculture Society.
Brito, Anabela Ben-Simon. 2012. "Insights into molecular and cellular events involved in normal and pathological vertebral development and fusion using zebrafish as model organism". Doutoramento. http://hdl.handle.net/10400.1/5754
Lisboa, Rodrigo. 2012. "Cytogenetic and histological studies of the brook trout (Salvelinus fontinalis) x arctic charr (Salvelinus alpinus) hybrids". Mestrado. http://hdl.handle.net/10400.1/5733
Carvalho, Inês Costa de. 2012. "Population structure of humpback whales (Megaptera novaeangliae) in west coast of Africa". Mestrado. http://hdl.handle.net/10400.1/12188
Cancela, Leonor; Laizé, Vincent; Conceição, N.; Tiago, Daniel M.; Maia, A. T.; Bensimon-Brito, A.; Gavaia, Paulo J.. 2012. "Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs". Em Matrix Gla protein expression: a complex process involving the use of alternative promoters, multiple splicing events and microRNAs.: The Federation of European Biochemical Societies.
Leonor Cancela; Leite, Ricardo B; Schnorr, KM; Anderson L. 2012. "Polypeptides having cellulose activity and polynucleotides encoding same". Dinamarca. Concedida/Emitida.
D Tiago; Conceição, Natércia; V Laizé; ML Cancela. 2012. Evidences for post-transcriptional regulation of MGP: can microRNAs regulate tissue calcification?. Em FEBS International Workshop “New Developments in RNA Biology". https://doi.org/10.1158/1538-7445.fbcr13-ia5
B Simões; Conceição, Natércia; RN Kelsh; ML Cancela. 2012. Identification and in vitro/in vivo functional characterization of zebrafish runx3 alternative promoters. Em FEBS International Workshop “New Developments in RNA Biology".
AP Gandolfo; IAL Silva; ML Cancela; Conceição, Natércia. 2012. Zebrafish: a good model to study XPG pathologies?. Em XXXVII JPG Congress. https://doi.org/10.1158/1538-7445.am2017-804
IAL Silva; R Leite; ML Cancela; Conceição, Natércia. 2012. TFIIH is remarkably conserved between zebrafish and human. Em 5Th Clinical Biochemistry Workshop.
A Adrião; Conceição, Natércia; IAL Silva; M Grazina; ML Cancela. 2012. Validation of zebrafish as a model to study mef2c pathologies. Em 5Th Clinical Biochemistry Workshop.
Fonseca, V.G.; Rosa, J.; Laizé, V.; Gavaia, P.J.; Cancela, M.L.. 2011. "Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream". Gene Expression Patterns, 11 (7): 448-455. https://doi.org/10.1016/j.gep.2011.07.003
Tiago, D.M.; Cancela, M.L.; Laizé, V.. 2011. "Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells". Journal of Bone and Mineral Metabolism, 29 (3): 377-382. https://doi.org/10.1007/s00774-010-0243-7
Sousa, S.; Afonso, N.; Bensimon-Brito, A.; Fonseca, M.; Simões, M.; Leon, J.; Roehl, H.; Cancela, M.L.; Jacinto, A.. 2011. "Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration". Development, 138 (18): 3897-3905. https://doi.org/10.1242/dev.064717
Cancela, Maria Leonor; Leite, Ricardo B.. 2011. "Exploring an uncommon host-parasite interaction to unveil the uniqueness of Perkinsus sp as a model organism". Doutoramento. http://hdl.handle.net/10400.1/5704
Dionísio, G.; Cancela, Leonor; Gavaia, Paulo J.. 2011. Effect of dietary vitamin K supplementation on skeletal development of Danio rerio. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Dionísio, G.; Conceição, L. E. C.; Hamre, K.; Cancela, Leonor. 2011. Effects of phylloquinone on Solea senegalensis skeletogenesis. Em World Aquaculture 2011- Aquaculture for a changing world. June 6-10 2011, Natal convention center, Natal, Brazil..
Cardeira, J.; Mendes, A. C.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2011. "Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis)". Em Development of chondroid tissues in lordotic-kyphotic Senegalese sole (Solea senegalensis). Faro, Portugal: Centro de Ciências do Mar.
Dionísio, G.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. 2011. Effect of warfarin in zebrafish (Danio rerio) bone formation during caudal fin regeneration. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Nicolau, L.; Cancela, Leonor; Pousão-Ferreira, P.. 2011. Early osteological development and deformities of Diplodus sargus (Linnaeus, 1758) and Diplodus vulgaris (Saint-Hillaire, 1817). Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Valles, E.; Cardeira, J.; Dionísio, G.; Estévez, A.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2011. Early axial and appendicular skeletal development of the meagre (Argyrosomus regius). A comparison of two rearing systems. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Simão, Márcio Alexandre Filipe. 2011. "Identificação e caracterização de duas isoformas da Ferritina da amêijoa R. decussatus e avaliação de algumas das suas propriedades biológicas". Mestrado. http://hdl.handle.net/10400.1/2655
Gavaia, Paulo J.; Dionísio, G.; Campos, C.; Carvalho, A. P.; Conceição, L. E. C.; Cancela, Leonor. 2011. Temperature affects skeletogenesis during Senegalese sole (Solea senegalensis, Kaup) larval development. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Silva, Iris Alexandra Lopes da. 2011. "Molecular cloning and analysis of Xeroderma pigmentosum group-D (xpd) in zebrafish". Mestrado. http://hdl.handle.net/10400.1/2233
Milan, Massimo; Coppe, Alessandro; Reinhardt, Richard; Cancela, Leonor; Leite, Ricardo B.; Saavedra, Carlos; Ciofi, Claudio; et al. 2011. "Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring". BMC Genomics, 12 (1). https://doi.org/10.1186/1471-2164-12-234
Rafael, M. S.. 2011. "Role of the transcriptional regulator FHL2: identification of fish target genes and regulatory mechanisms". Doutoramento. http://hdl.handle.net/10400.1/3734
Dias, J.; Rodrigues, V.; Colen, Rita; Rosa, Joana; Viegas, M. N.; Cardeira, J.; Cancela, Leonor; Gavaia, Paulo J.; Laizé, Vincent. 2011. Dietary lipid quality regulates bone composition and metabolism in gilthead seabream (Sparus aurata) juveniles. Em Interdisciplinary Approaches in Fish Skeletal Biology, April 26-28, Tavira, Portugal..
Gavaia, Paulo J.; Dionísio, G.; Cardeira, J.; Cunha, M. E.; Pousão-Ferreira, P.; Conceição, L. E. C.; Cancela, Leonor. 2011. Skeletal quality in Senegalese sole: characterization of fish resulting from environmental and nutritional trials. Em Workshop Cultivation of soles.
Tiago, Daniel; Laizé, Vincent; Bargelloni, Luca; Ferraresso, Serena; Romualdi, Chiara; Cancela, Leonor; Tiago, D.M.; et al. 2011. "Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate". BMC Genomics, 12. https://doi.org/10.1186/1471-2164-12-310
A Adrião; Conceição, Natércia; M Grazina; ML Cancela. 2011. Expression, regulation and interaction with target genes in health and disease. Em DCBM Ph.D. student seminars.
C Fazenda; ML Cancela; Conceição, Natércia. 2011. Molecular characterization and expression of a novel Gla-containing protein, Gla-rich protein (Grp), in zebrafish. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.
IAL Silva; ML Cancela; Conceição, Natércia. 2011. xpd mutations in zebrafish: is there a bone phenotype?. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.
Fazenda, C.; Simões, B.; Kelsh, R.N.; Cancela, M.L.; Conceição, N.. 2010. "Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis". Gene, 450 (1-2): 94-102. https://doi.org/10.1016/j.gene.2009.10.007
Viegas, C.S.B.; Conceiçao, N.; Fazenda, C.; Simes, D.C.; Cancela, M.L.. 2010. "Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon (Acipenser naccarii)". Journal of Applied Ichthyology, 26 (2): 214-218. https://doi.org/10.1111/j.1439-0426.2010.01408.x
Rafael, M.S.; Marques, C.L.; Parameswaran, V.; Cancela, M.L.; Laizé, V.. 2010. "Fish bone-derived cell lines: An alternative in vitro cell system to study bone biology". Journal of Applied Ichthyology, 26 (2): 230-234. https://doi.org/10.1111/j.1439-0426.2010.01411.x
Louro, B.; Passos, A.L.S.; Souche, E.L.; Tsigenopoulos, C.; Beck, A.; Lagnel, J.; Bonhomme, F.; et al. 2010. "Gilthead sea bream (Sparus auratus) and European sea bass (Dicentrarchus labrax) expressed sequence tags: Characterization, tissue-specific expression and gene markers". Marine Genomics, 3 (3-4): 179-191. https://doi.org/10.1016/j.margen.2010.09.005
Cancela, M.L.; Witten, P.E.. 2010. "Advances in skeletal biology by understanding the fish skeleton: A multidisciplinary challenge". Journal of Applied Ichthyology, 26 (2). https://doi.org/10.1111/j.1439-0426.2010.01393.x
Simão, M.F.; Leite, R.B.; Rocha, C.; Cancela, M.L.. 2010. "Changes in bioturbation of iron biogeochemistry and in molecular response of the clam ruditapes decussates upon perkinsus olseni infection". Archives of Environmental Contamination and Toxicology, 59 (3): 433-443. https://doi.org/10.1007/s00244-010-9490-9
Conceição, N.; Cox, C.J.; Simões, B.; Viegas, M.; Cancela, M.L.. 2010. "Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes". Journal of Applied Ichthyology, 26 (2): 245-250. https://doi.org/10.1111/j.1439-0426.2010.01415.x
Rosa, J.; Tiago, D.M.; Dias, J.; Cancela, M.L.; Laizé, V.. 2010. "Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells". Journal of Applied Ichthyology, 26 (2): 251-256. https://doi.org/10.1111/j.1439-0426.2010.01414.x
Bensimon-Brito, A.; Cancela, M.L.; Huysseune, A.; Witten, P.E.. 2010. "The zebrafish (Danio rerio) caudal complex - a model to study vertebral body fusion". Journal of Applied Ichthyology, 26 (2): 235-238. https://doi.org/10.1111/j.1439-0426.2010.01412.x
Rafael, S. M.; Laize, V.; Schule, R.; Cancela, M. L.. 2010. "Fish as a suitable model to unveil the function of the four and half LIM domains protein 2". Febs Journal, 277: 183-183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100642&KeyUID=WOS:000278565100642
Leite, R. B.; Cancela, M. L.. 2010. "Changes at transcriptome level during host-parasite interaction using Perkinsus olseni as a model". Febs Journal, 277: 118-118. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000278565100422&KeyUID=WOS:000278565100422
Cardeira, J.; Nicolau, L.; Pousão-Ferreira, P.; Cancela, Leonor; Gavaia, Paulo J.. 2010. "Early skeletal development of meagre (Argyrosomus regius, Asso 1801)".
Gavaia, Paulo J.; Richard, Nadège; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2010. "Evaluation of the skeletal quality in Senegalese sole (Solea Senegalensis, Kaup) reared under intensive vs extensive conditions".
ML Cancela; Bensimon-Brito, Anabela; Gavaia, P; Laizé, V. 2010. "Integrated screening methods for identifying modulators of mineralization, and modulators identified therefrom". Concedida/Emitida.
M Leonor Cancela; Gavaia, P; Bensimon-Brito, Anabela; Laizé, V. 2010. " Identification of compound that affects osteogenesis, involves inducing fin regeneration of ray-finned fish by amputating fish fin, contacting fish with test compound, and determining re-mineralization index of fin regeneration". Estados Unidos. Concedida/Emitida.
Leonor Cancela; Laizé, V; Leite, Ricardo B; Danielsen S; Skov LK. 2010. "New isolated polypeptide having organophosphorous hydrolase activity selected from polypeptide containing amino acid sequence, polypeptide encoded by polynucleotide, variant containing deletion of amino acids, used in nucleic acid construct". Estados Unidos. Concedida/Emitida.
Leonor Cancela; Simes, Dina; S B Viegas, Carla. 2010. "A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof". Expirada.
Leonor Cancela; Danielsen, Steffen ; Skov LK; Leite, Ricardo B; Laizé, V.. 2010. "New isolated polypeptide having organophosphorous hydrolase activity selected from polypeptide containing amino acid sequence, polypeptide encoded by polynucleotide, variant containing deletion of amino acids, used in nucleic acid construct". Dinamarca. Concedida/Emitida.
Leonor Cancela; Laizé, V; Leite, Ricardo B; Danielsen, Steffen ; Skov LK. 2010. "New isolated polypeptide with organophosphorus hydrolase activity selected from e.g. polypeptide with amino acid sequence having specific identity to mature polypeptide and polypeptide encoded by polynucleotide, used in such as composition". Dinamarca. Concedida/Emitida.
Leonor Cancela; Simes, Dina; Viegas, Carla. 2010. " A gammacarboxyglutamate-rich protein, methods and assays for its detection, purification and quantification and uses thereof". Concedida/Emitida.
C Fazenda; Conceição, Natércia; ML Cancela. 2010. Identification of two isoforms of Gla Rich Protein (GRP) in zebrafish and its molecular characterization. Em XVII National Congress of Biochemistry. https://doi.org/10.1158/1538-7445.am2011-3895
B Simões; Conceição, Natércia; R Kelsh; ML Cancela. 2010. runx3 promoter analysis and expression patterns in tissues and during development of zebrafish. Em XVII National Congress of Biochemistry.
IAL Silva; C Fazenda; Conceição, Natércia; ML Cancela. 2010. Study of the Xeroderma pigmentosum D (XPD) expression in zebrafish. Em XVII National Congress of Biochemistry.
C Fazenda; Conceição, Natércia; ML Cancela. 2010. Molecular characterization of gla rich protein (GRP) gene expression and function using zebrafish as model system. Em Biomedical Sciences Ph.D. students seminars.
M Sousa; C Fazenda; Conceição, Natércia; ML Cancela. 2010. Matrix Gla Protein is a target gene for transcription factor MEF2C. Em Science Meeting 2010.
Conceição, Natércia; A Lelo; JP Pinto; ML Cancela. 2010. Regulation of hepcidin expression: in silico promoter analysis. Em SINAL 2010.
Conceição, Natércia; C Fazenda; C Viegas; R Leite; ML Cancela. 2010. Promoter analysis of cartilage-expressed genes. Em 4Th Clinical Biochemistry Workshop.
Ascenso, R.M.T.; Leite, R.B.; Afonso, R.; Cancela, M.L.. 2009. "Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis". Journal of Fish Diseases, 32 (7): 633-636. https://doi.org/10.1111/j.1365-2761.2009.01039.x
Viegas, C.S.B.; Cavaco, S.; Neves, P.L.; Ferreira, A.; João, A.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Simes, D.C.. 2009. "Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications". American Journal of Pathology, 175 (6): 2288-2298. https://doi.org/10.2353/ajpath.2009.090474
Gavaia, Paulo J.; Richard, N.; Dâmaso, L.; Dinis, Maria Teresa; Pousão-Ferreira, P.; Engrola, S.; Conceição, L. E. C.; Cancela, Leonor. 2009. "Skeletal evaluation and technical improvements to decrease the incidence of skeletal deformities in Solea senegalensis, Kaup".
Gavaia, Paulo Jorge; Domingues, Susana; Engrola, Sofia; Drake, Pilar; Sarasquete, Carmen; Dinis, M Teresa; Cancela, M Leonor; et al. 2009. "Comparing skeletal development of wild and hatchery-reared Senegalese sole (Solea senegalensis, Kaup 1858): evaluation in larval and postlarval stages". Aquaculture Research, 40 (14): 1585-1593. https://doi.org/10.1111/j.1365-2109.2009.02258.x
Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus maximus)".
Cardeira da Silva, J.; Dionísio, G.; Bensimon-Brito, A.; Cancela, Leonor; Gavaia, Paulo J.. 2009. "Skeletal development and performance of zebrafish Danio rerio (Hamilton, 1822) larvae and juvenile fish fed with different diets".
Santos, Rui Pedro Peres dos. 2009. "O efeito da Varfarina no desenvolvimento esquelético de larvas de peixe zebra (Danio rerio)". Mestrado. http://hdl.handle.net/10400.1/11039
Roberto, V.; Cavaco, S.; Viegas, C. S. B.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Gavaia, Paulo J.; et al. 2009. "Matrix gla protein in turbot (Scophthalmus maximus): gene expression analysis and identification of sites of protein accumulation". Aquaculture, 294 (3-4): 202-211. https://doi.org/10.1016/j.aquaculture.2009.06.020
Silva, João Pedro Gonçalves Cardeira da. 2009. "O efeito da dieta na sobrevivência e no desenvolvimento esquelético e digestivo de larvas e juvenis de peixe-zebra Danio rerio (Hamilton, 1822)". Mestrado. http://hdl.handle.net/10400.1/672
Marques, C. L.; Rafael, M. S.; Tiago, Daniel M.; Cancela, Leonor; Laizé, Vincent. 2009. "Desenvolvimento de sistemas celulares de peixe adequados ao estudo da mineralização in vitro". CanalBQ, 15-20. http://hdl.handle.net/10400.1/4289
Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor. 2009. "Warfarin effects in the skeletal development of zebrafish (Danio rerio)".
Laizé, Vincent; Tiago, Daniel; Aureliano, M.; Cancela, Leonor; Laizé, V.; Tiago, D.M.; Cancela, M.L.. 2009. "New insights into mineralogenic effects of vanadate". Cellular and Molecular Life Sciences, 66 (24): 3831-3836. https://doi.org/10.1007/s00018-009-0137-9
M Leonor Cancela; Gavaia, P; Laizé, V; Anabela Bensimon-Brito. 2009. "Identification of compound that affects osteogenesis, involves inducing fin regeneration of ray-finned fish by amputating fish fin, contacting fish with test compound, and determining re-mineralization index of fin regeneration". Expirada.
B Simões; Conceição, Natércia; ML Cancela; RN Kelsh. 2009. Investigation of runx3 expression pattern and function in zebrafish peripheral nervous system development. Em 6th European Zebrafish Genetics and Development Meeting.
C Fazenda; CSB Viegas; Conceição, Natércia; DC Simes; ML Cancela. 2009. Development of molecular and cellular tools to study the function of skeletal Gla-containing proteins in sturgeon. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.
Conceição, Natércia; C Cox; B Simões; M Viegas; ML Cancela. 2009. Comparative promoter analysis and its application in analysis of cartilage-expressed genes regulation. Em Workshop - Interdisciplinary Approaches in Fish Skeletal Biology.
Leite, R.B.; Brito, A.B.; Cancela, M.L.. 2008. "An Oxygen Molecular Sensor, the HIF Prolyl 4-Hydroxylase, in the Marine Protist Perkinsus olseni". Protist, 159 (3): 355-368. https://doi.org/10.1016/j.protis.2008.03.002
Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Cancela, M.L.. 2008. "Effect of the herbicide Roundup® on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus". Bulletin of Environmental Contamination and Toxicology, 80 (6): 512-515. https://doi.org/10.1007/s00128-008-9412-y
Viegas, C.S.B.; Simes, D.C.; Laizé, V.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; S B Viegas, Carla; et al. 2008. "Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates". Journal of Biological Chemistry, 283 (52): 36655-36664. https://doi.org/10.1074/jbc.M802761200
Tiago, D.M.; Laizé, V.; Cancela, M.L.; Aureliano, M.. 2008. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". Cell Biology and Toxicology, 24 (3): 253-263. https://doi.org/10.1007/s10565-007-9034-x
Tiago, D.M.; Laizé, V.; Cancela, M.L.. 2008. "Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development". General and Comparative Endocrinology, 157 (2): 107-115. https://doi.org/10.1016/j.ygcen.2008.04.006
Tanguy, A.; Bierne, N.; Saavedra, C.; Pina, B.; Bachère, E.; Kube, M.; Bazin, E.; et al. 2008. "Increasing genomic information in bivalves through new EST collections in four species: Development of new genetic markers for environmental studies and genome evolution". Gene, 408 (1-2): 27-36. https://doi.org/10.1016/j.gene.2007.10.021
Coesel, S.N.; Baumgartner, A.C.; Teles, L.M.; Ramos, A.A.; Henriques, N.M.; Cancela, L.; Varela, J.C.S.. 2008. "Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress". Marine Biotechnology, 10 (5): 602-611. https://doi.org/10.1007/s10126-008-9100-2
Conceição, N.; Laizé, V.; Simões, B.; Pombinho, A.R.; Cancela, M.L.. 2008. "Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata". Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1779 (1): 28-39. https://doi.org/10.1016/j.bbagrm.2007.11.003
Tiago, D.M.; Cancela, M.L.; Aureliano, M.; Laizé, V.. 2008. "Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". FEBS Letters, 582 (9): 1381-1385. https://doi.org/10.1016/j.febslet.2008.03.025
Fonseca, Maria Leonor Quintais Cancela da; Vasta, Gerardo; Ascenso, Rita Margarida Teixeira. 2008. "Study of Perkinsus olseni infection mechanisms: identification and regulation of parasite genes differentially expressed in response to host and environmental stress". Doutoramento. http://hdl.handle.net/10400.1/301
Fonseca, Maria Leonor Quintais Cancela da; Gama, Francisco Miguel Portela da; Afonso, Ricardo. 2008. "Estudos sobre aproveitamento biotecnológico da quitina produzida por organismos marinhos". Mestrado. http://hdl.handle.net/10400.1/710
Dionísio, G.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2008. "Diets affect skeletal development in zebrafish (Danio rerio)".
Cardeira da Silva, J.; Gavaia, Paulo J.; Brito, A. B.; Cancela, Leonor. 2008. "The use of enhanced green fluorescent protein to track matrix Gla protein expression during zebrafish (Danio rerio) development".
Peres dos Santos, R.; Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2008. "Developmental effects of warfin in the skeletogenesis of zebrafish (Danio rerio) larvae".
Gavaia, Paulo J.; Cancela, Leonor. 2008. "Fish as a model organism to study skeletal development and associated pathologies".
Rainha, Rita Vanessa Cardoso de Almeida. 2008. "Estudo da variabilidade genética de marcadores moleculares ligados ao gene da MGP e sua aplicação para paternidades em Sparus aurata". Mestrado. http://hdl.handle.net/10400.1/530
Madeira, Céline Rodrigues. 2008. "Contribuição parental do linguado do Senegal, Solea senegalensis (KAUP 1858), em aquacultura". Mestrado. http://hdl.handle.net/10400.1/245
Tiago, Daniel M.. 2008. "Role of insulin and insulin-like peptides in bone formation: identification of bone-specific target genes and regulatory mechanisms, and characterization of the insulin-mimetic effect of vanadium". Doutoramento. http://hdl.handle.net/10400.1/422
Tiago, Daniel; Cancela, Leonor; Aureliano, M.; Laizé, Vincent. 2008. "Vanadate proliferative and anti-mineralogic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line". http://hdl.handle.net/10400.1/1359
Tiago, Daniel; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2008. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". https://doi.org/10.1007/s10565-007-9034-x
Tiago, Daniel; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2008. "Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line". http://hdl.handle.net/10400.1/1361
Fonseca, P. J.; Serrão, Ester; Pina-Martins, F.; Silva, P.; Mira, Sara; Quartau, J. A.; Paulo, O. S.; et al. 2008. "The evolution of Cicada songs contrasted with the relationships inferred from mitochondrial DNA (Insecta, hemiptera)". Bioacoustics, 18 (1): 17-34. https://doi.org/10.1080/09524622.2008.9753588
Dina C. Simes; Carla B. Viegas; Matthew K. Williamson; Paul A. Price; Leonor Cancela. 2008. "Purification of matrix Gla protein and osteocalcin from the adriatic sturgeon (Acipencer naccarii), an Ancient bony fish with a cartilaginous endoskeleton". Bone, 42: S65-S65. https://doi.org/10.1016/j.bone.2007.12.116
B Simões; D Rodrigues; Conceição, Natércia; RN Kelsh; ML Cancela. 2008. Spatial-temporal expression of Runx3 during early zebrafish development and in silico and in vitro analysis of its promoter regions. Em XVIth National Congress of Biochemistry.
Conceição, Natércia; C Cox; B Simões; M Viegas; ML Cancela. 2008. Computational identification of regulatory motifs in cartilage-expressed genes using zebrafish as an in vivo model. Em XVIth National Congress of Biochemistry.
C Fazenda; Conceição, Natércia; ML Cancela. 2008. Possible regulation of the matrix gla protein gene by the transcription factor mef2c. Em XVIth National Congress of Biochemistry.
Conceição, Natércia; C Fazenda; B Simões; ML Cancela. 2008. Transcriptional regulation of the Xenopus laevis Matrix Gla Protein gene expression. Em 35th European Symposium on Calcified Tissues.
Conceição, Natércia; V Laizé; ML Cancela. 2008. Regulation of Matrix Gla Protein gene expression in teleost fish sparus aurata. Em MGE - Marine Genomics Europe Final Assembly.
Conceição, Natércia; B Simões; ML Cancela; RN Kelsh. 2008. runx3 structure and function in zebrafish neural crest: expression pattern and morpholino knockdown. Em Seminários de Mar e Ambiente 2008.
Kohli, V.; Robles, V.; Cancela, M.L.; Acker, J.P.; Waskiewicz, A.J.; Elezzabi, A.Y.. 2007. "An alternative method for delivering exogenous material into developing zebrafish embryos". Biotechnology and Bioengineering, 98 (6): 1230-1241. https://doi.org/10.1002/bit.21564
Fonseca, V.G.; Laizé, V.; Valente, M.S.; Cancela, M.L.. 2007. "Identification of an osteopontin-like protein in fish associated with mineral formation". FEBS Journal, 274 (17): 4428-4439. https://doi.org/10.1111/j.1742-4658.2007.05972.x
Robles, V.; Cancela, M.L.. 2007. "Lipid-based transfection as a method for gene delivery in zebrafish (Danio rerio) embryos". Aquaculture Research, 38 (12): 1317-1322. https://doi.org/10.1111/j.1365-2109.2007.01806.x
Rønnestad, I.; Gavaia, P.J.; Viegas, C.S.B.; Verri, T.; Romano, A.; Nilsen, T.O.; Jordal, A.-E.O.; Kamisaka, Y.; Cancela, M.L.. 2007. "Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): Cloning, tissue expression and comparative aspects". Journal of Experimental Biology, 210 (22): 3883-3896. https://doi.org/10.1242/jeb.007898
Robles, V.; Barbosa, V.; Herráez, M.P.; Martínez-Páramo, S.; Cancela, M.L.. 2007. "The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures". Theriogenology, 68 (2): 284-289. https://doi.org/10.1016/j.theriogenology.2007.05.003
Abreu, Maria Manuela Silva Nunes Reis; Santos, Maria Cristina Amaral Penas Nabais dos; Fonseca, Maria Leonor Quintais Cancela da; Santos, Erika Silva. 2007. "Potencial de utilização de Cistus ladanifer L. na vegetalização de áreas mineiras". Mestrado. http://hdl.handle.net/10400.1/1798
Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. 2007. "Gene expression during regeneration of zebrafish (danio rerio) fins: relative expression levels of mineralization – related gla proteins". Em Meeting of European COST B23 Action "Oral Development and Regeneration”oceedings of the . Barcelona, Espanha: Universitat de Barcelona.
Marques, C. L.; Rafael, M. S.; Cancela, Leonor; Laizé, Vincent; Marques, C.L.; Rafael, M.S.; Cancela, M.L.; Laizé, V.. 2007. "Establishment of primary cell cultures from fish calcified tissues". Cytotechnology, 55 (1): 9-13. https://doi.org/10.1007/s10616-007-9098-8
Tiago, Daniel M.; Laizé, Vincent; Cancela, Leonor; Aureliano, M.. 2007. "Vanadate and bone metabolism: effect on proliferation and mineralization of fish bone-derived cells".
Brito, A. B.; Cancela, Leonor; Gavaia, Paulo J.. 2007. "Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio". Em Conference Proceedings, 265-306.: Elsevier.
Tiago, Daniel M.; Laizé, Vincent; Aureliano, M.; Cancela, Leonor. 2007. "Vanadate effects on bone metabolism: fish cell lines as an alternative to mammalian in vitro systems". Em Vanadium Biochemistry , 1-12. Vol. chapter 14. Kerala, Índia: Research Signpost. http://hdl.handle.net/10400.1/1302
Pittman, K.; Rønnestad, I.; Gavaia, Paulo J.; Cancela, Leonor; Guerreiro, P. M.; Ribeiro, Laura; Aragão, C.; et al. 2007. "Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms". Trabalho apresentado em Aquaculture Europe,2007, 5-10.
Conceição, Natércia; J Belo; ML Cancela. 2007. "Alternate promoters and developmental modulation of expression of the Xenopus laevis MGP gene". Trabalho apresentado em Experimental Pathology and Health Sciences, 1 (1).
Conceição, Natércia; C Fazenda; B Simões; ML Cancela. 2007. Identification of a new Runx2 isoform in Xenopus laevis: molecular organization, tissue distribution and effect on MGP gene transcription. Em MICRO’07 BIOTEC’07-XXXIII JPG Congress.
M Viegas; Conceição, Natércia; J Fidalgo; ML Cancela. 2007. Characterization of a Xenopus laevis bone derived cell line, X1, capable of mineralizing in vitro. Em MICRO’07 BIOTEC’07-XXXIII JPG Congress.
Conceição, Natércia; C Fazenda; B Simões; ML Cancela. 2007. Identification of new Runx2 isoforms from Xenopus laevis capable of inducing MGP gene expression in vitro. Em IVth National RNA Meeting.
B Simões; Conceição, Natércia; J Belo; ML Cancela. 2007. Analysis of Xenopus laevis MGP knockdown phenotype: expression pattern of developmental marker genes. Em IVth National RNA Meeting.
B Simões; Conceição, Natércia; ML Cancela; RN Kelsh. 2007. Effects of Runx3 isoforms on distribution and migration of zebrafish neural crest cells. Em Workshop “Mechanisms of early development: cell fate determination, morphogenesis and patterning.
B Simões; A.Silva; M Vitorino; Conceição, Natércia; J Belo; ML Cancela. 2007. Spatio-temporal pattern of expression and regulation of matrix Gla protein (MGP) during early development in Xenopus laevis. Em 32rd FEBS Congress. https://doi.org/10.1109/icpr.2008.4761009
Conceição, Natércia; B Simões; C Fazenda; ML Cancela. 2007. Runx2-mediated regulation of the Matrix Gla Protein gene. Em 32rd FEBS Congress.
Ortiz-Delgado, J.B.; Simes, D.C.; Viegas, C.S.B.; Schaff, B.J.; Sarasquete, C.; Cancela, M.L.. 2006. "Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: Preferential protein accumulation in skeletal and vascular systems". Histochemistry and Cell Biology, 126 (1): 89-101. https://doi.org/10.1007/s00418-005-0125-6
Gavaia, P.J.; Simes, D.C.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Pinto, J.P.; Kelsh, R.N.; Sarasquete, M.C.; Cancela, M.L.. 2006. "Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): Comparative gene and protein expression during larval development through adulthood". Gene Expression Patterns, 6 (6): 637-652. https://doi.org/10.1016/j.modgep.2005.11.010
Braga, D.; Laizé, V.; Tiago, D.M.; Cancela, M.L.. 2006. "Enhanced DNA transfer into fish bone cells using polyethylenimine". Molecular Biotechnology, 34 (1): 51-54. https://doi.org/10.1385/MB:34:1:51
Simões, B.; Conceição, N.; Viegas, C.S.B.; Pinto, J.P.; Gavaia, P.J.; Hurst, L.D.; Kelsh, R.N.; Cancela, M.L.. 2006. "Identification of a promoter element within the Zebrafish colXa1 gene responsive to Runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2aA2". Calcified Tissue International, 79 (4): 230-244. https://doi.org/10.1007/s00223-006-0111-6
Laizé, V.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.. 2006. "Identification of an osteocalcin isoform in fish with a large acidic prodomain". Journal of Biological Chemistry, 281 (22): 15037-15043. https://doi.org/10.1074/jbc.M600373200
Rafael, M.S.; Laizé, V.; Cancela, M.L.. 2006. "Identification of Sparus aurata bone morphogenetic protein 2: Molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates". Bone, 39 (6): 1373-1381. https://doi.org/10.1016/j.bone.2006.06.021
Cancela, Maria Leonor; Dias, Pedro Beja; Dias, Paula; Mira, Sara. 2006. "Population genetics of an endangered species: the Bonelli's eagle (Hieraaetus fasciatus)". Doutoramento. http://hdl.handle.net/10400.1/10627
Cancela, Maria Leonor; Gavaia, Paulo; Roberto, Vânia Cristina Palma. 2006. "Gla protein localization and histological characterization of bone stuctures in relevant aquaculture fish". Mestrado. http://hdl.handle.net/10400.1/11026
Laizé, Vincent; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2006. "Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods". Em Whole-genome sequence analysis: Evidences for new osteocalcin isoforms in fish and tetrapods. Prague, República Checa: European Society for Developmental Evolutionary Biology.
Roberto, V.; Gavaia, Paulo J.; Cancela, Leonor. 2006. "Vertebral deformities and local accumulation of gla proteins in sparus aurata". Em Vertebral deformities and local accumulation of gla proteins in sparus aurata. Florence, Itália: Aqua 2006.
Brito, A. B.; Gavaia, Paulo J.; Cancela, Leonor. 2006. "Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization related Gla proteins". Em Regeneration in Zebrafish (Danio rerio) fins: pattern of expression of mineralization¿related Gla proteins, editado por Sociedade Portuguesa de Bioquimica. Aveiro, Portugal: Sociedade Portuguesa de Bioquímica.
Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Verri, T.; Cancela, Leonor. 2006. "PepT1 in a coldwater marine teleost larvae- Atlantic cod: cloning and preliminary studies of expression and phylogeny". Acta Bio Medica. , 77. http://hdl.handle.net/10400.1/4498
Silva, Maria da Conceição Monteiro Patrício. 2006. "Desenvolvimento de ferramentas interactivas para divulgação das aplicações da biotecnologia ambiental em biorremediação". Mestrado. http://hdl.handle.net/10400.1/14813
B Simões; A.Silva; Conceição, Natércia; M Vitorino; J. Belo; ML Cancela. 2006. Spatial-temporal pattern of expression and regulation of matrix Gla protein (MGP) during early development in Xenopus laevis. Em XV National Congress of Biochemistry.
Conceição, Natércia; J Fidalgo; B Simões; ML Cancela. 2006. Regulation of the Xenopus laevis MGP promoters by transcription factors: NF-AT and Runx2. Em Workshop Mineralised tissue formation, regeneration, and repair.
Conceição, Natércia; A.Silva; B Simões; J. Belo; ML Cancela. 2006. , Mapping of the cis-regulatory elements in the XlMGP promoters by cell culture experiments and microinjection of Xenopus laevis embryos using deletion mutant constructs. Em 4th Meeting of the Centre of Marine and Environmental Investigation.
AR Pombinho; V Laizé; Conceição, Natércia; ML Cancela. 2006. Regulators of MGP gene expression in Sparus aurata VSa13 bone-derived cell line. Em Seminários “Mar e Ambiente”.
Engrola, S.; Conceição, L.E.C.; Gavaia, P.J.; Cancela, M.L.; Dinis, M.T.. 2005. "Effects of pre-weaning feeding frequency on growth, survival, and deformation of Senegalese sole, Solea senegalensis (Kaup, 1858)". Israeli Journal of Aquaculture - Bamidgeh, 57 (1): 10-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344396118&partnerID=MN8TOARS
Laizé, V.; Pombinho, A.R.; Cancela, M.L.; Laizé, Vincent; Pombinho, A. R.; Cancela, Leonor. 2005. "Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: Evidence for more than one osteonectin in Salmonidae". Biochimie, 87 (5): 411-420. https://doi.org/10.1016/j.biochi.2005.01.008
Elandalloussi, L.M.; Leite, R.B.; Rodrigues, P.M.; Afonso, R.; Nunes, P.A.; Cancela, M.L.. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". Aquaculture, 243 (1-4): 9-17. https://doi.org/10.1016/j.aquaculture.2004.09.038
Fonseca, V.G.; Lago-Lestón, A.; Laizé, V.; Cancela, M.L.; Fonseca, V. G.; Laizé, Vincent; Cancela, Leonor. 2005. "Rapid identification of differentially expressed genes by in situ screening of bacteria". Molecular Biotechnology, 30 (2): 163-165. https://doi.org/10.1385/MB:30:2:163
Elandalloussi, L.M.; Rodrigues, P.M.; Afonso, R.; Leite, R.B.; Nunes, P.A.; Cancela, M.L.. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". Molecular and Biochemical Parasitology, 142 (1): 106-109. https://doi.org/10.1016/j.molbiopara.2005.03.014
Frazão, C.; Simes, D.C.; Coelho, R.; Alves, D.; Williamson, M.K.; Price, P.A.; Cancela, M.L.; Carrondo, M.A.. 2005. "Structural evidence of a fourth Gla residue in fish osteocalcin: Biological implications". Biochemistry, 44 (4): 1234-1242. https://doi.org/10.1021/bi048336z
Conceição, N.; Silva, A.C.; Fidalgo, J.; Belo, J.A.; Cancela, M.L.. 2005. "Identification of alternative promoter usage for the matrix Gla protein gene: Evidence for differential expression during early development in Xenopus laevis". FEBS Journal, 272 (6): 1501-1510. https://doi.org/10.1111/j.1742-4658.2005.04590.x
Mira, S.; Wolff, K.; Cancela, M.L.. 2005. "Isolation and characterization of microsatellite markers in Bonelli's eagle (Hieraaetus fasciatus)". Molecular Ecology Notes, 5 (3): 493-495. https://doi.org/10.1111/j.1471-8286.2005.00967.x
Ortiz-Delgado, J. B.; Simes, Dina; Gavaia, Paulo J.; Sarasquete, C.; Cancela, Leonor; Ortiz-Delgado, J.B.; Simes, D.C.; Gavaia, P.; Cancela, M.L.. 2005. "Osteocalcin and Matrix Gla Protein in developing teleost teeth. Identification of sites of mRNA and protein accumulation at single cell resolution". Histochemistry and Cell Biology, 124 (2): 123-130. https://doi.org/10.1007/s00418-005-0015-y
Mariani, Valentina; Viegas, C. A.; Gavaia, Paulo J.; Cancela, Leonor; Giuffra, Elisabetta. 2005. "Comparative analysis of gene expression profiles among distantly related fish species. Insight into skeletal and immunological systems".
Laizé, Vincent; Martel, Paulo; Viegas, Carla; Price, P. A.; Cancela, Leonor; Laizé, V.; Martel, P.; et al. 2005. "Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates". Journal of Biological Chemistry, 280 (29): 26659-26668. https://doi.org/10.1074/jbc.M500257200
Cancela, Leonor; Laizé, Vincent; Simes, Dina; Gavaia, Paulo J.; Conceição, N.; Viegas, C. S. B.; Pombinho, A. R.; et al. 2005. "Proteínas gla do osso e cartilagem: importância dos anfíbios e peixes como modelos biológicos para elucidação da sua função e evolução - gla proteins in bone and cartilage: the importance of fish and amphibian models to understand their function and evolution".
Engrola, S.; Conceição, L. E. C.; Gavaia, Paulo J.; Cancela, Leonor; Dinis, Maria Teresa. 2005. "Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858)". Despite much interest in the production of Senegalese sole (Solea senegalensis) in southern Europe, weaning of this species onto artificial diets is problematic and varying results are obtained. The aim of this study was to test two feeding frequencies during a 13-day pre-weaning period and assess their impact on the growth and survival of Senegalese sole. Postlarvae were fed Artemia metanauplii w. http://hdl.handle.net/10400.1/4483
Elandalloussi, L. M.; Rodrigues, Pedro; Afonso, R.; Leite, R. B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
Gavaia, Paulo J.. 2005. "Functional analysis of bone related Gla proteins from bony fish during skeletal development". Doutoramento. http://hdl.handle.net/10400.1/7614
Elandalloussi, Laurence M.; Leite, Ricardo B.; Rodrigues, Pedro; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Elandalloussi, Laurence M.; Rodrigues, Pedro; Afonso, Ricardo; Leite, Ricardo B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
Elandalloussi, L. M.; Leite, R. B.; Rodrigues, Pedro; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Fonseca, Vera Alexandra Garcia. 2005. "Up-regulated genes during in vitro mineralization of Sparus aurata osteoblast-like cells". Mestrado. http://hdl.handle.net/10400.1/11058
Elandalloussi, L. M.; Rodrigues, Pedro; Afonso, R.; Leite, R. B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
Pinto, Jorge; Conceição, Natércia; S B Viegas, Carla; Leite, Ricardo; Hurst, L. D.; Kelsh, R. N.; Leonor Cancela, M.; et al. 2005. "Identification of a new pebp2 alpha A2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro". Journal of Bone and Mineral Research, 20 (8): 1440-1453. https://doi.org/10.1359/JBMR.050318
Elandalloussi, Laurence M.; Leite, Ricardo B.; Rodrigues, Pedro; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Elworthy, S.; P Pinto, Jorge; Pettifer, A.; Leonor Cancela, M.; Kelsh, R. N.; Pinto, J.P.; Cancela, M.L.; Kelsh, R.N.. 2005. "Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent". Mechanisms of Development, 122 (5): 659-669. https://doi.org/10.1016/j.mod.2004.12.008
Elandalloussi, L. M.; Leite, R. B.; Rodrigues, Pedro; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Effect of antiprotozoal drugs on the proliferation of the bivalve parasite Perkinsus olseni". https://doi.org/10.1016/j.aquaculture.2004.09.038
Elandalloussi, Laurence M.; Rodrigues, Pedro; Afonso, Ricardo; Leite, Ricardo B.; Nunes, Patrícia A.; Cancela, Leonor. 2005. "Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni". https://doi.org/10.1016/j.molbiopara.2005.03.014
B Simões; Conceição, Natércia; CSB Viegas; JP Pinto; P Gavaia; RN Kelsh; ML Cancela. 2005. Gene structure, Runx2-dependent regulation and spatial-temporal expression of collagen X¿1 during early zebrafish development. Em Microscopy in Motion - XLth Meeting of the SPME-BC.
Gomes, H.L.; Leite, R.B.; Afonso, R.; Stallinga, P.; Cancela, M.L.; Gomes, Henrique L.; Leite, R. B.; Stallinga, Peter; Cancela, M. Leonor. 2004. "A microelectrode impedance method to measure interaction of cells". https://doi.org/10.1109/ICSENS.2004.1426344
Simes, D.C.; Williamson, M.K.; Schaff, B.J.; Gavaia, P.J.; Ingleton, P.M.; Price, P.A.; Cancela, M.L.; et al. 2004. "Characterization of Osteocalcin (BGP) and Matrix Gla Protein (MGP) Fish Specific Antibodies: Validation for Immunodetection Studies in Lower Vertebrates". Calcified Tissue International, 74 (2): 170-180. https://doi.org/10.1007/s00223-003-0079-4
Elandalloussi, L.M.; Leite, R.M.; Afonso, R.; Nunes, P.A.; Robledo, J.A.F.; Vasta, G.R.; Cancela, M.L.. 2004. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". Molecular and Cellular Probes, 18 (2): 89-96. https://doi.org/10.1016/j.mcp.2003.09.008
Streiff, R.; Mira, S.; Castro, M.; Cancela, M.L.. 2004. "Multiple paternity in Norway lobster (Nephrops norvegicus L.) assessed with microsatellite markers". Marine Biotechnology, 6 (1): 60-66. https://doi.org/10.1007/s10126-003-0015-7
Leite, R.B.; Afonso, R.; Cancela, M.L.. 2004. "Perkinsus sp. infestation in carpet-shell clams, Ruditapes decussatus (L), along the Portuguese coast. Results from a 2-year survey". Aquaculture, 240 (1-4): 39-53. https://doi.org/10.1016/j.aquaculture.2004.05.014
Viegas, C. S. B.; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. 2004. "Gla proteins as markers for studies of skeletal development and malformations in new aquaculture fish species (Pagrus auriga, Diplodus sargo and Scophtalmus maximus)".
Inácio, Ana Rita da Silva. 2004. "Selecção de áreas prioritárias para a conservação da biodiversidade no sul de Portugal". Mestrado. http://hdl.handle.net/10400.1/1641
Pombinho, António José Ribeiro. 2004. "Reguladores da expressão do gene da proteía Gla da matriz (MGP) numa linha celular derivada de peixe". Mestrado. http://hdl.handle.net/10400.1/8554
Brito, A. B.; Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2004. "Expression of the oligopeptide transporter PepT1 (Solute carrier family 15, member 1), in fed and starved larval Zebra fish (Danio rerio)".
Elandalloussi, L. M.; Leite, R. M.; Afonso, R.; Nunes, Patrícia A.; Robledo, J. A. F.; Vasta, G. R.; Cancela, Leonor. 2004. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". https://doi.org/10.1016/j.mcp.2003.09.008
Rønnestad, I.; Gavaia, Paulo J.; Viegas, C. S. B.; Cancela, Leonor. 2004. "Cloning and ontogenetic expression of the oligopeptide transporter PepT1 (Solute carrier family 15, member 1), in fed and starved larval Atlantic cod, Gadus morhua L".
Domingues, S.; Gavaia, Paulo J.; Cancela, Leonor. 2004. "Effect of Citral in zebrafish bone structure and circulatory system during the first stages of development".
Elandalloussi, L. M.; Leite, R. M.; Afonso, R.; Nunes, Patrícia A.; Robledo, J. A. F.; Vasta, G. R.; Cancela, Leonor. 2004. "Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs". https://doi.org/10.1016/j.mcp.2003.09.008
Pombinho, A. R.; Laizé, Vincent; Molha, D. M.; Marques, S.; Cancela, Leonor; Pombinho, A.R.; Laizé, V.; et al. 2004. "Development of two bone-derived cell lines from the marine teleost Sparus aurata; evidence for extracellular matrix mineralization and cell-type-specific expression of matrix Gla protein and osteocalcin". Cell and Tissue Research, 315 (3): 393-406. https://doi.org/10.1152/
JP Pinto; Conceição, Natércia; CSB Viegas; RB Leite; RN Kelsh; ML Cancela. 2004. Identification of a new pebp2¿A2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. Em XIV National Congress of Biochemistry.
J Fidalgo; Conceição, Natércia; J Pinto; ML Cancela. 2004. Hormonal regulation of Matrix Gla Protein expression in a Xenopus laevis bone-derived cell culture. Em XIV National Congress of Biochemistry.
AR Pombinho; V Laizé; Conceição, Natércia; ML Cancela. 2004. Regulation of matrix Gla protein gene expression in a fish bone-derived cell line. Em XIV National Congress of Biochemistry.
B Simões; Conceição, Natércia; CSB Viegas; JP Pinto; ML Cancela. 2004. Molecular cloning of the zebrafish (Danio rerio) Collagen Xalpha1 cDNA and gene. Identification of promoter regulatory elements. Em XIV National Congress of Biochemistry. https://doi.org/10.1063/1.5000196
Aurelle, D.; Guillemaud, T.; Afonso, P.; Morato, T.; Wirtz, P.; Serrão Santos, R.; Cancela, M.L.. 2003. "Genetic study of Coris julis (Osteichtyes, Perciformes, Labridae) evolutionary history and dispersal abilities". Comptes Rendus - Biologies, 326 (8): 771-785. https://doi.org/10.1016/j.crvi.2003.08.001
Pinto, J.P.; Conceição, N.; Gavaia, P.J.; Cancela, M.L.. 2003. "Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata". Bone, 32 (3): 201-210. https://doi.org/10.1016/S8756-3282(02)00981-X
Simes, D.C.; Williamson, M.K.; Ortiz-Delgado, J.B.; Viegas, C.S.B.; Price, P.A.; Cancela, M.L.; Simes, DC; et al. 2003. "Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: Calcified cartilage and not bone as the primary site of MGP accumulation in fish". Journal of Bone and Mineral Research, 18 (2): 244-259. https://doi.org/10.1359/jbmr.2003.18.2.244
Elandalloussi, L. M.; Afonso, R.; Nunes, Patrícia A.; Cancela, Leonor; Elandalloussi, L.M.; Nunes, P.A.; Cancela, M.L.. 2003. "Effect of desferrioxamine and 2,2 '-bipyridyl on the proliferation of Perkinsus atlanticus". Biomolecular Engineering, 20 (4-6): 349-354. https://doi.org/10.1016/S1389-0344(03)00047-9
Gavaia, Paulo J.; Simes, Dina; Ortiz-Delgado, J. B.; Sarasquete, C.; Cancela, Leonor. 2003. "Simultaneous detection of osteocalcin and matrix gla protein in developmental stages of zebra fish (Danio rerio)". https://doi.org/10.1007/s00223-003-5002-5
Pinto, J. P.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. 2003. "Matrix Gla protein gene expression and protein accumulation co-localize with cartilage distribution during development of the teleost fish Sparus aurata". https://doi.org/10.1016/S8756-3282(02)00981-X
Pais, Susana Isabel da Silva. 2003. "A legislação portuguesa de segurança biológica, um instrumento de gestão ambiental?". Mestrado. http://hdl.handle.net/10400.1/8520
Guerreiro, Miguel. 2003. "Monitorização da actividade bioelectroquímica da bomba de cálcio do retículo sarcoplasmático". Licenciatura. http://hdl.handle.net/10400.1/4828
Pinto, J. P.; Conceição, N.; Gavaia, Paulo J.; Cancela, Leonor. 2003. "Matrix Gla protein gene expression and protein accumulation co-localize with cartilage distribution during development of the teleost fish Sparus aurata". https://doi.org/10.1016/S8756-3282(02)00981-X
Leite, Ricardo B.; Rodrigues, Pedro; Elandalloussi, Laurence M.; Afonso, Ricardo; Nunes, Patrícia A.; Cancela, Leonor. 2003. "Perkinsus Atlanticus – desenvolvimento de um método de diagnóstico para detecção de infecção em moluscos bivalves". http://hdl.handle.net/10400.1/4335
Robledo, J.A.F.; Nunes, P.A.; Cancela, M.L.; Vasta, G.R.. 2002. "Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus". Journal of Eukaryotic Microbiology, 49 (5): 414-422. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036710887&partnerID=MN8TOARS
Viegas, C.S.B.; Pinto, J.P.; Conceição, N.; Simes, D.C.; Cancela, M.L.. 2002. "Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin". Gene, 289 (1-2): 97-107. https://doi.org/10.1016/S0378-1119(02)00480-8
Mira, S.; Billot, C.; Guillemaud, T.; Palma, L.; Cancela, M.L.. 2002. "Isolation and characterization of polymorphic microsatellite markers in Eurasian vulture Gyps fulvus". Molecular Ecology Notes, 2 (4): 557-558. https://doi.org/10.1046/j.1471-8286.2002.00314.x
Conceição, N.; Henriques, N.M.; Ohresser, M.C.P.; Hublitz, P.; Schüle, R.; Cancela, M.L.. 2002. "Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis: Functional analysis of the promoter identifies a calcium sensitive region required for basal activity". European Journal of Biochemistry, 269 (7): 1947-1956. https://doi.org/10.1046/j.1432-1327.2002.02846.x
Leite, Ricardo B.; Gavaia, Paulo J.; Cancela, Leonor. 2002. "Localization of sites of expression of the BAT-1 gene enconding a RNA Helicase".
Simes, Dina Cristina F. R. Costa. 2002. "Purification, biochemical characterization and localization at single cell resolution of Matrix Gla Protein (MGP) and Bone Gla Protein (BGP) in the teleost fish Argyrosomus regius". Doutoramento. http://hdl.handle.net/10400.1/8458
Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor; Gavaia, P.J.; Dinis, M.T.; Cancela, M.L.. 2002. "Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis)". Aquaculture, 211 (1-4): 305-323. https://doi.org/10.1016/S0044-8486(02)00167-9
Robledo, J. A. F.; Nunes, Patrícia A.; Cancela, Leonor; Vasta, G. R.. 2002. "Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus". https://doi.org/10.1111/j.1550-7408.2002.tb00221.x
Henriques, M.; Lourenco, R.; Almada, F.; Calado, G.; Goncalves, D.; Guillemaud, Thomas; Cancela, M. Leonor; et al. 2002. "A revision of the status of Lepadogaster lepadogaster (Teleostei : Gobiesocidae): sympatric subspecies or a long misunderstood blend of species?". Biological Journal of the Linnean Society, 76 (3): 327-338. https://doi.org/10.1111/j.1095-8312.2002.tb01700.x
JP Pinto; Conceição, Natércia; PJ Gavaia; ML Cancela. 2002. Co-localization of Matrix Gla protein gene expression and protein accumulation with cartilage distribution in the teleost fish Sparus aurata. Em XIII National Congress of Biochemistry.
J Fidalgo; Conceição, Natércia; JP Pinto; ML Cancela. 2002. Retinoic acid induction of matrix Gla protein expression in a Xenopus laevis bone derived cell line. Em XIII National Congress of Biochemistry.
Streiff, R.; Guillemaud, T.; Alberto, F.; Magalhães, J.; Castro, M.; Cancela, M.L.. 2001. "Isolation and characterization of microsatellite loci in the Norway lobster (Nephrops norvegicus)". Molecular Ecology Notes, 1 (1-2): 71-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346342219&partnerID=MN8TOARS
Cancela, M.L.; Ohresser, M.C.P.; Reia, J.P.; Viegas, C.S.B.; Williamson, M.K.; Price, P.A.. 2001. "Matrix Gla protein in Xenopus laevis: Molecular cloning, tissue distribution, and evolutionary considerations". Journal of Bone and Mineral Research, 16 (9): 1611-1621. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034868048&partnerID=MN8TOARS
Palma, L.; Mira, S.; Cardia, P.; Beja, P.; Guillemaud, T.; Ferrand, N.; Cancela, M.L.; Da Fonseca, L.C.. 2001. "Sexing bonelli's eagle nestlings: Morphometrics versus molecular techniques". Journal of Raptor Research, 35 (3): 187-193. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344361957&partnerID=MN8TOARS
Pinto, J.P.; Ohresser, M.C.P.; Cancela, M.L.. 2001. "Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man". Gene, 270 (1-2): 77-91. https://doi.org/10.1016/S0378-1119(01)00426-7
Simes, Dina; Gavaia, Paulo J.; Ortiz-Delgado, J. B.; Pinto, J. P.; Cancela, Leonor. 2001. "Characterization of specific antibodies for fish osteocalcin and its usefulness to investigate osteocalcin tissue distribution in lower vertebrates.". Calcified Tisue International, 74: 170-180. http://hdl.handle.net/10400.1/4426
Pinto, J. P.; Gavaia, Paulo J.; Simes, Dina; Kelsh, R. N.; Cancela, Leonor. 2001. "Localization of osteocalcin (BGP) during fish (Sparus aurata) development by in situ hybridization and immunohistochemistry: comparison between gene expression/protein distribution and skeletal mineralization".
Gavaia, Paulo J.; Viegas, C. A.; Pinto, J. P.; Sarasquete, C.; Cancela, Leonor. 2001. "Detection and localization of osteocalcin (BGP or Bone Gla Protein) in teleosts by in situ hybridization and immunohistochemistry". Bone, 28 (5). http://hdl.handle.net/10400.1/4468
Pearson, G. A.; Serrão, Ester; Cancela, Leonor; Pearson, G.; Serrão, E.A.; Cancela, M.L.. 2001. "Suppression subtractive hybridization for studying gene expression during aerial exposure and desiccation in fucoid algae". European Journal of Phycology, 36 (4): 359-366. https://doi.org/10.1080/09670260110001735508
Pinto, Idílio Jorge Matias Pereira. 2001. "Cloning of the Bone Gla Protein gene from the teleost fish Sparus aurata (gilthead seabream). Molecular organization, developmental appearance and evolutionary implications". Doutoramento. http://hdl.handle.net/10400.1/7187
Cancela, M. Leonor; Ohresser, M. C. P.; Reia, J. P.; S B Viegas, Carla; Williamson, M. K.; Price, P. A.. 2001. "Matrix gla protein in xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations". https://doi.org/10.1359/jbmr.2001.16.9.1611
Conceição, Natércia; R Schule; ML Cancela. 2001. Characterization of the 5´flanking region of the Xenopus laevis matrix Gla protein (MGP) gene. Em 27th FEBS/PABMB Meeting.
Gavaia, P.J.; Sarasquete, C.; Cancela, M.L.. 2000. "Detection of mineralized structures in early stages of development of marine Teleostei using a modified alcian blue-alizarin red double staining technique for bone and cartilage". Biotechnic and Histochemistry, 75 (2): 79-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033860776&partnerID=MN8TOARS
Guillemaud, T.; Cancela, M.L.; Afonso, P.; Morato, T.; Santos, R.S.; Wirtz, P.. 2000. "Molecular insights into the taxonomic status of Coris atlantica (Pisces: Labridae)". Journal of the Marine Biological Association of the United Kingdom, 80 (5): 929-933. https://doi.org/10.1017/S0025315400002915
Guillemaud, T.; Almada, F.; Santos, R.S.; Cancela, M.L.. 2000. "Interspecific utility of microsatellites in fish: A case study of (CT)(n) and (GT)(n) markers in the shanny Lipophrys pholis (Pisces: Blenniidae) and their use in other blennioidei". Marine Biotechnology, 2 (3): 248-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034190159&partnerID=MN8TOARS
Carvalho, M.C.; Streiff, R.; Guillemaud, T.; Afonso, P.; Santos, R.S.; Cancela, M.L.. 2000. "Isolation and characterization of polymorphic microsatellite markers in Abudefduf luridus (Pisces: Pomacentridae)". Molecular Ecology, 9 (7): 993-994. https://doi.org/10.1046/j.1365-294X.2000.00939.x
Guillemaud, T.; Streiff, R.; Santos, R.S.; Afonso, P.; Morato, T.; Cancela, M.L.. 2000. "Microsatellite characterization in the rainbow wrasse Coris julis (Pisces: Labridae)". Molecular Ecology, 9 (5): 631-632. https://doi.org/10.1046/j.1365-294X.2000.00882-1.x
Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor. 2000. "Skeletal development as an assessment criteria for larval Solea senegalensis (Kaup) quality". Em Skeletal development as an assessment criteria for larval Solea senegalensis (Kaup) quality.
ML Cancela; DC Simes; P Rodrigues; Conceição, Natércia; JP Reia; MK Williamson; PA Price. 2000. Expression of Matrix Gla Protein (MGP) in fish and amphibian: a model system to study the evolution of MGP function. Em ASBMR 22st Annual Meeting, Metro Toronto Convention Centre.
Conceição, Natércia; M Ohresser; N Henriques; Prof. Dr. Roland Schule; ML Cancela. 1999. Molecular cloning and regulation of the Xenopus laevis Matrix Gla protein gene. Em ASBMR 21st Annual Meeting.
Gavaia, Paulo J.; Dinis, Maria Teresa; Cancela, Leonor. 1998. "Detection of skeletal abnormalities in hatchery reared Solea senegalensis (Kaup, 1858) by a whole mount double staining technique". Em Detection of Skeletal abnormalities in hatchery reared Solea senegalensis (Kaup, 1858) by a whole mount double staining technique, editado por Sociedade Portuguesa de Biotecnologia;. Portugal: Sociedade Portuguesa de Biotecnologia; Universidade do Minho.
Conceição, Natércia; NM Henriques; M Ohresser; ML Cancela. 1998. Characterization of Matrix Gla protein (MGP) gene from Xenopus laevis (Daudin, 1802). Em XI National Congress of Biochemistry.
Cancela, M.L.; Hu, B.; Price, P.A.. 1997. "Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells". Journal of Cellular Physiology, 171 (2): 125-134. https://doi.org/10.1002/(SICI)1097-4652(199705)171:2<125::AID-JCP2>3.0.CO;2-Q
Kirfel, J.; Kelter, M.; Cancela, L.M.; Price, P.A.; Schüle, R.. 1997. "Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene". Proceedings of the National Academy of Sciences of the United States of America, 94 (6): 2227-2232. https://doi.org/10.1073/pnas.94.6.2227
Henriques, Nuno Miguel Carvalho de Sousa de Paula. 1997. "Clonagem do gene de matrix gla protein (MGP) da espécie xenopus leavis (Daudin, 1802)". Mestrado. http://hdl.handle.net/10400.1/10979
Navalho, João. 1997. "Biotecnologia de Dunaliella salina para produção de B caroteno". Mestrado. http://hdl.handle.net/10400.1/8469
Gavaia, Paulo J.; Faustino, M.; Cancela, Leonor. 1996. "Identification of bone gla protein during early development of Solea Senegalensis". Em Identification of bone gla protein during early development of Solea Senegalensis, editado por Sociedade Portuguesa de Bioquimica. Portugal: Sociedade Portuguesa de Bioquimica; Universidade do Minho.
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1995. "Amino-acid sequence of bone Gla protein from the African clawed toad Xenopus laevis and the fish Sparus aurata". International Journal of Peptide and Protein Research, 46 (5): 419-423. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028864789&partnerID=MN8TOARS
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1994. "The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants". Journal of Biological Chemistry, 269 (16): 12185-12189. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028233411&partnerID=MN8TOARS
Rannels, S.R.; Cancela, M.L.; Wolpert, E.B.; Price, P.A.. 1993. "Matrix Gla protein mRNA expression in cultured type II pneumocytes". American Journal of Physiology - Lung Cellular and Molecular Physiology, 265 (3 9-3). http://www.scopus.com/inward/record.url?eid=2-s2.0-0027453375&partnerID=MN8TOARS
Cancela, M.L.; Williamson, M.K.; Price, P.A.. 1993. "Retinoic acid increases matrix gla protein in rat plasma". Nutrition Research, 13 (1): 87-91. https://doi.org/10.1016/S0271-5317(05)80659-1
Cancela, M.L.; Price, P.A.. 1992. "Retinoic acid induces matrix gla protein gene expression in human cells". Endocrinology, 130 (1): 102-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026553049&partnerID=MN8TOARS
Cancela, L.; Ishida, H.; Bishop, J.E.; Norman, A.W.. 1992. "Local chromatin changes accompany the expression of the calbindin-D28K gene: Tissue specificity and effect of vitamin D activation". Molecular Endocrinology, 6 (3): 468-475. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026525323&partnerID=MN8TOARS
Cancela, L.; Hsieh, C.-L.; Francke, U.; Price, P.A.. 1990. "Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene". Journal of Biological Chemistry, 265 (25): 15040-15048. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025029949&partnerID=MN8TOARS
Cancela, L.; Theofan, G.; Norman, A.W.. 1988. Chapter 15 The pleiotropic vitamin D hormone. Editado por BA Cooke, RJB King, HJ Van der Molen. Vol. 18. New York, Estados Unidos: Elsevier Science Publishers B.V. https://doi.org/10.1016/S0167-7306(08)60650-X
PARISI, M; CANCELA, L; Parisi, M.; Cancela, L.. 1988. "TIME COURSE STUDIES ON PHOSPHATE TRANSFER IN FROG URINARY-BLADDER". Kidney International, 33 (1): 58-63. https://doi.org/10.1038/ki.1988.9
Cancela, L.; Nemere, I.; Norman, A.W.. 1988. "1a,25 (OH)2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms". Journal of Steroid Biochemistry, 30 (1-6): 33-39. https://doi.org/10.1016/0022-4731(88)90073-8
De Vernejoul, M.C.; Benamout, M.P.; Cancela, L.; Miravet, L.; Kuntz, D.; Gueris, J.; Gardin, J.P.. 1988. "Primary hyperparathyroidism seen in rheumatology. Clinical manifestations and relationship between bone history and biological parameters ". Revue du Rhumatisme et des Maladies Osteo-Articulaires, 55 (7): 489-494. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024005167&partnerID=MN8TOARS
Minghetti, P.P.; Cancela, L.; Fujisawa, Y.; Theofan, G.; Norman, A.W.. 1988. "Molecular structure of the chicken vitamin D-induced calbindin-D(28K) gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements". Molecular Endocrinology, 2 (4): 355-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023879973&partnerID=MN8TOARS
Rebut-Bonneton, C.; Ly, S.Y.; Cancela, L.. 1988. "Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement". Hormone and Metabolic Research, 20 (6): 339-343. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023941120&partnerID=MN8TOARS
Cancela, L.; Rebut-Bonneton, C.. 1987. "Regulation of 24-hydroxylase activity in mouse skin fibroblasts by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine". Journal of Steroid Biochemistry, 28 (5): 479-484. https://doi.org/10.1016/0022-4731(87)90505-X
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1987. "Lack of biological activity of vitamin D3-3ß sulfate during lactation in vitamin D-deficient rats". Reproduction Nutrition Developpement, 27 (6): 979-997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023502969&partnerID=MN8TOARS
Le Boulch, N.; Cancela, L.; Miravet, L.; Lange, C.. 1986. "Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry". Biomedical Mass Spectrometry, 13 (2): 53-56. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022572865&partnerID=MN8TOARS
Gruson, M.; Cancela, L.; Denne, M.A.; Miravet, L.. 1986. "Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants.". Endocrinologia experimentalis, 20 (2-3): 329-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022759472&partnerID=MN8TOARS
Cancela, L.; Le Boulch, N.; Miravet, L.. 1986. "Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants". Journal of Endocrinology, 110 (1): 43-50. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022445355&partnerID=MN8TOARS
Marie, P.J.; Cancela, L.; Le Boulch, N.; Miravet, L.. 1986. "Bone changes due to pregnancy and lactation: Influence of vitamin D status". American Journal of Physiology - Endocrinology and Metabolism, 251 (4). http://www.scopus.com/inward/record.url?eid=2-s2.0-0022966994&partnerID=MN8TOARS
Le Boulch, N.; Cancela, L.; Miravet, L.. 1986. "Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants". Endocrinologia Experimentalis, 20 (2-3): 325-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022981264&partnerID=MN8TOARS
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1985. "Vitamin D3 3ß sulfate has less biological activity than free vitamin D3 during pregnancy in rats". Biology of the Neonate, 48 (5): 274-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-0022271864&partnerID=MN8TOARS
Cancela, L.; Marie, P.J.; Le Boulch, N.; Miravet, L.. 1985. "Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups". Journal of Endocrinology, 105 (3): 303-309. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021848253&partnerID=MN8TOARS
Rebut-Bonneton, C.; Demignon, J.; Cancela, L.; Miravet, L.. 1985. "Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat". Reproduction Nutrition Developpement, 25 (3): 583-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021870967&partnerID=MN8TOARS
Cancela, L.; Le Boulch, N.; Miravet, L.. 1984. "Action of vitamin D3-3 beta-sulfate during lactation in the rat.". World review of nutrition and dietetics, 43: 153-157. http://www.scopus.com/inward/record.url?eid=2-s2.0-0021143980&partnerID=MN8TOARS
de Vernejoul, M.C.; Girot, R.; Gueris, J.; Cancela, L.; Bang, S.; Bielakoff, J.; Mautalen, C.; Goldberg, D.; Miravet, L.. 1982. "Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia". Journal of Clinical Endocrinology and Metabolism, 54 (2): 276-281. http://www.scopus.com/inward/record.url?eid=2-s2.0-0019960606&partnerID=MN8TOARS
Boulch, N.L.; Cancela, L.; Miravet, L.. 1982. "Cholecalciferol sulfate identification in human milk by HPLC". Steroids, 39 (4): 391-398. https://doi.org/10.1016/0039-128X(82)90063-0
 

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