Silhueta de pessoa indiferenciada

Alexandra Binnie

Professor associado convidado
Faculdade de Medicina e Ciências Biomédicas
Subsistema
Docentes Universitário
Regime
Tempo integral
Vínculo
CT em Funções Públicas a termo resolutivo certo

Projetos

Projetos
2022/01 - 2027/12. The Life-Threatening Illness National Group (LifTING) Research Training Platform: Spanning Boundaries Between Research and Care.
2022/10 - 2024/09. Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial.
2019/10 - 2024/09. EpiGen Marks for Human Sepsis.
2021/09 - 2024/08. Factors Influencing Canadian Community Intensive Care Unit (ICU) Participation in Clinical Research: A Qualitative Descriptive Study.
2022/02 - 2024/01. COVID-19 And Severe Community-Acquired Pneumonia Dynamic Evaluation Study (CASCADES - ARBS CORONA III).
2022/10 - 2023/09. Driving Pressure-Limited Ventilation in Hypoxemic Respiratory Failure: the DRIVE RCT.
2022/06 - 2023/05. Canadian Critical Care Trials Group COVID-19 Response: defining critical care capacity in Canada; testing treatments through large-scale adaptive clinical trials; & establishing the evidence base to inform clinical and health system management decisions.
2022/03 - 2023/02. Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial.
2021/12 - 2022/11. CANCOV2.0: 2-year follow up of the Canadian COVID-19 Prospective Cohort Study.
2021/10 - 2022/09. Lung and Diaphragm Protection in Acute Hypoxemic Respiratory Failure: the LANDMARK II Pilot and Feasibility Randomized Clinical Trial.
2020/10 - 2022/09. Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): A Randomized Controlled Clinical Trial.
2021/01 - 2022/06. The Canadian Network of COVID-19 Clinical Trials Networks.
2021/06 - 2022/05. The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-acquired Pneumonia (REMAP-CAP): Building an International Research Response to Variant COVID-19.
2020/07 - 2021/06. Canadian COVID-19 Prospective Cohort Study (CanCOV).
2015/05 - 2016/04. Epigenetic Profiling in Severe Sepsis (EPSIS).
2001/04 - 2002/03. PGSB.
1999/04 - 2000/03. PGSA/ESA.

Produções

Alexandra Binnie; Kyra Moura; Claire Moura; Frédérick D’Aragon; Jennifer L. Y. Tsang. 2021. "Psychosocial distress amongst Canadian intensive care unit healthcare workers during the acceleration phase of the COVID-19 pandemic". PLOS ONE. https://doi.org/10.1371/journal.pone.0254708
Alexandra Binnie; Emanuel Fernandes; Helder Almeida-Lousada; Ramon Andrade de Mello; Pedro Castelo-Branco. 2021. "CRISPR-based strategies in infectious disease diagnosis and therapy". Infection. https://doi.org/10.1007/s15010-020-01554-w
Angus, Derek C; Derde, Lennie; Al-Beidh, Farah; Annane, Djillali; Arabi, Yaseen; Beane, Abigail; Van Bentum-Puijk, Wilma; et al. 2020. "Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.". JAMA. https://doi.org/10.17863/cam.60052
WHO Solidarity Trial Consortium; Pan, Hongchao; Peto, Richard; Henao-Restrepo, Ana-Maria; Preziosi, Marie-Pierre; Sathiyamoorthy, Vasee; Abdool Karim, Quarraisha; et al. 2021. "Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.". New England Journal of Medicine, 384: 497-511. https://doi.org/10.1056/nejmoa2023184
Jennifer L. Y. Tsang; Alexandra Binnie; Robert A. Fowler. 2021. "Twenty articles that critical care clinicians should read about COVID-19". Intensive Care Medicine, 47 (3): 337-341. https://doi.org/10.1007/s00134-020-06329-3
Jennifer L Y Tsang; Alexandra Binnie; George Farjou; Dimitra Fleming; Maham Khalid; Erick Duan. 2020. "Participation of more community hospitals in randomized trials of treatments for COVID-19 is needed.". Canadian Medical Association Journal, 192: E555-E555. https://doi.org/10.1503/cmaj.75585
Binnie, Alexandra. 2019. "Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.". Critical care medicine. https://doi.org/10.1097/ccm.0000000000004097
Binnie, A.; Walsh, C.J.; Hu, P.; Dwivedi, D.J.; Fox-Robichaud, A.; Liaw, P.C.; Tsang, J.L.Y.; et al. 2020. "Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness". Critical care medicine, 48 (2): 142-150. https://doi.org/10.1097/CCM.0000000000004097
Binnie, Alexandra. 2019. "Fostering community hospital research.". CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. https://doi.org/10.1503/cmaj.190055
Binnie, Alexandra. 2019. "Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers.". BMC cancer. https://doi.org/10.1186/s12885-019-5403-0
Binnie, Alexandra. 2017. "Epigenetic therapy in urologic cancers: an update on clinical trials.". Oncotarget. https://doi.org/10.18632/oncotarget.14226
Binnie, Alexandra. 2014. "Biomarkers in acute respiratory distress syndrome.". Current opinion in critical care. https://doi.org/10.1097/mcc.0000000000000048
Binnie, A.; Tsang, J.L.Y.; Dos Santos, C.C.. 2014. "Biomarkers in acute respiratory distress syndrome". Current Opinion in Critical Care, 20 (1): 47-55. https://doi.org/10.1097/MCC.0000000000000048
Binnie, Alexandra. 2006. "Homologous gene sequences mediate transcription-domain formation.". Journal of cell science. https://doi.org/10.1242/jcs.03050
Binnie, Alexandra. 2002. "Promoter proximal splice sites enhance transcription.". Genes & development. https://doi.org/10.1101/gad.983602
Binnie, Alexandra. 1999. "Gamma-irradiation directly affects the formation of coding joints in SCID cell lines.". Journal of immunology (Baltimore, Md. : 1950). http://europepmc.org/abstract/med/10553067
Tsang JLY; Fowler R; Cook DJ; Ma H; Binnie A. 2021. "How can we increase participation in pandemic research in Canada?". Canadian journal of anaesthesia = Journal canadien d'anesthesie. https://doi.org/10.1007/s12630-021-02119-7
Sholzberg M; Tang GH; Rahhal H; AlHamzah M; Kreuziger LB; Áinle FN; Alomran F; et al. 2021. "Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial.". BMJ (Clinical research ed.). https://doi.org/10.1136/bmj.n2400
Writing Committee for the REMAP-CAP Investigators; Estcourt LJ; Turgeon AF; McQuilten ZK; McVerry BJ; Al-Beidh F; Annane D; et al. 2021. "Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2021.18178
Johnstone J; Meade M; Lauzier F; Marshall J; Duan E; Dionne J; Arabi YM; et al. 2021. "Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2021.13355
Taher J; Mighton C; Chowdhary S; Casalino S; Frangione E; Arnoldo S; Bearss E; et al. 2021. "Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort study.". BMJ open. https://doi.org/10.1136/bmjopen-2021-052842
ATTACC Investigators; ACTIV-4a Investigators; REMAP-CAP Investigators; Lawler PR; Goligher EC; Berger JS; Neal MD; et al. 2021. "Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2105911
REMAP-CAP Investigators; ACTIV-4a Investigators; ATTACC Investigators; Goligher EC; Bradbury CA; McVerry BJ; Lawler PR; et al. 2021. "Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2103417
Arabi YM; Gordon AC; Derde LPG; Nichol AD; Murthy S; Beidh FA; Annane D; et al. 2021. "Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.". Intensive care medicine. https://doi.org/10.1007/s00134-021-06448-5
Salluh JIF; Arabi YM; Binnie A. 2021. "COVID-19 research in critical care: the good, the bad, and the ugly.". Intensive care medicine. https://doi.org/10.1007/s00134-021-06367-5
REMAP-CAP Investigators; Gordon AC; Mouncey PR; Al-Beidh F; Rowan KM; Nichol AD; Arabi YM; et al. 2021. "Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2100433
Arabi YM; Azoulay E; Al-Dorzi HM; Phua J; Salluh J; Binnie A; Hodgson C; et al. 2021. "How the COVID-19 pandemic will change the future of critical care.". Intensive care medicine. https://doi.org/10.1007/s00134-021-06352-y
Lau VI; Cook DJ; Fowler R; Rochwerg B; Johnstone J; Lauzier F; Marshall JC; et al. 2020. "Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol.". BMJ open. https://doi.org/10.1136/bmjopen-2019-036047
Binnie A; Tsang JLY; Hu P; Carrasqueiro G; Castelo-Branco P; Dos Santos CC. 2020. "Epigenetics of Sepsis.". Critical care medicine. https://doi.org/10.1097/ccm.0000000000004247
Binnie A; Lage J; Dos Santos C. 2019. "How can biomarkers be used to differentiate between infection and non-infectious causes of inflammation?". Evidence-Based Practice of Critical Care. http://europepmc.org/abstract/PMC/PMC7152028
Binnie, A.; Olson, S.; Wu, G.E.; Lewis, S.M.. 1999. "Gamma-irradiation directly affects the formation of coding joints in SCID cell lines". Journal of Immunology, 163 (10): 5418-5426. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571736&partnerID=MN8TOARS
Nádia Silva; Ana Teresa Rajado; Filipa Esteves; David Brito; Joana Apolónio; Vânia Palma Roberto; Alexandra Binnie; et al. 2023. "Measuring healthy ageing: current and future tools". Biogerontology. https://doi.org/10.1007/s10522-023-10041-2
Casalino S; Frangione E; Chung M; MacDonald G; Chowdhary S; Mighton C; Faghfoury H; et al. 2022. "Genome screening, reporting, and genetic counseling for healthy populations.". Human genetics. https://doi.org/10.1007/s00439-022-02480-7
Tsang JLY; Binnie A; Duan EH; Johnstone J; Heels-Ansdell D; Reeve B; Trop S; et al. 2022. "Academic and Community ICUs Participating in a Critical Care Randomized Trial: A Comparison of Patient Characteristics and Trial Metrics.". Critical care explorations. https://doi.org/10.1097/cce.0000000000000794
Hays LMC; Black M; Prunty MP; Murthy S; van de Veerdonk FL; Annane D; Binnie A; et al. 2022. Could treatment with immunomodulatory agents targeting IL-1, IL-6, or JAK signalling improve outcomes in patients with severe influenza pneumonia? A systematic and narrative review. https://doi.org/10.12688/hrbopenres.13613.1
Burns KEA; Moss M; Lorens E; Jose EKA; Martin CM; Viglianti EM; Fox-Robichaud A; et al. 2022. "Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey.". Critical care medicine. https://doi.org/10.1097/ccm.0000000000005674
Lau VI; Binnie A; Basmaji J; Baig N; Opgenorth D; Cameron S; O'Hearn K; et al. 2021. "Needs Assessment Survey Identifying Research Processes Which may be Improved by Automation or Artificial Intelligence: ICU Community Modeling and Artificial Intelligence to Improve Efficiency (ICU-Comma).". Journal of intensive care medicine. https://doi.org/10.1177/08850666211064844
Writing Committee for the REMAP-CAP Investigators; Higgins AM; Berry LR; Lorenzi E; Murthy S; McQuilten Z; Mouncey PR; et al. 2023. "Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2022.23257
Conway Morris A; Kohler K; De Corte T; Ercole A; De Grooth HJ; Elbers PWG; Povoa P; et al. 2022. "Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set.". Critical care (London, England). https://doi.org/10.1186/s13054-022-04108-8
Greco M; De Corte T; Ercole A; Antonelli M; Azoulay E; Citerio G; Morris AC; et al. 2022. "Correction to: Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.". Intensive care medicine. https://doi.org/10.1007/s00134-022-06801-2
Greco M; De Corte T; Ercole A; Antonelli M; Azoulay E; Citerio G; Morris AC; et al. 2022. "Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study.". Intensive care medicine. https://doi.org/10.1007/s00134-022-06705-1
Mourão Carvalho N; Martins C; Cartaxo V; Marreiros A; Justo E; Raposo C; Binnie A. 2022. "Out-of-hospital cardiac arrest in the Algarve region of Portugal: a retrospective registry trial with outcome data.". European journal of emergency medicine : official journal of the European Society for Emergency Medicine. https://doi.org/10.1097/mej.0000000000000885
Ali K; Azher T; Baqi M; Binnie A; Borgia S; Carrier FM; Cavayas YA; et al. 2022. "Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial.". CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. https://doi.org/10.1503/cmaj.211698
Conway Morris A; Kohler K; De Corte T; Ercole A; De Grooth HJ; Elbers PWG; Povoa P; et al. 2022. "Correction: Co-infection and ICU-acquired infection in COVID-19 ICU patients: a secondary analysis of the UNITE-COVID data set.". Critical care (London, England). https://doi.org/10.1186/s13054-022-04124-8
Mestre A; Muster M; El Adib AR; Ösp Egilsdottir H; Byermoen KR; Padilha M; Aguilar T; et al. 2022. "The impact of small-group virtual patient simulator training on perceptions of individual learning process and curricular integration: a multicentre cohort study of nursing and medical students.". BMC medical education. https://doi.org/10.1186/s12909-022-03426-3
Tsang JLY; Fowler R; Cook DJ; Burns KEA; Hunter K; Forcina V; Hwang A; et al. 2022. "Motivating factors, barriers and facilitators of participation in COVID-19 clinical research: A cross-sectional survey of Canadian community intensive care units.". PloS one. https://doi.org/10.1371/journal.pone.0266770
REMAP-CAP Writing Committee for the REMAP-CAP Investigators; Bradbury CA; Lawler PR; Stanworth SJ; McVerry BJ; McQuilten Z; Higgins AM; Mouncey PR; Gordon AC. 2022. "Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2022.2910
Quigley N; Binnie A; Baig N; Opgenorth D; Senaratne J; Sligl WI; Zuege DJ; et al. 2023. "Modelling the potential increase in eligible participants in clinical trials with inclusion of community intensive care unit patients in Alberta, Canada: a decision tree analysis.". Canadian journal of anaesthesia = Journal canadien d'anesthesie. https://doi.org/10.1007/s12630-023-02669-y
Siegal DM; Belley-Côté EP; Lee SF; Hill S; D'Aragon F; Zarychanski R; Rochwerg B; et al. 2023. "Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2023.20820
Kloss P; Lindholz M; Milnik A; Azoulay E; Cecconi M; Citerio G; De Corte T; et al. 2023. "Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study.". Annals of intensive care. https://doi.org/10.1186/s13613-023-01201-1
LOVIT-COVID Investigators; on behalf of the Canadian Critical Care Trials Group; and the REMAP-CAP Investigators; Adhikari NKJ; Hashmi M; Lamontagne F. 2023. "Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.". JAMA. https://doi.org/10.1001/jama.2023.21407
Granton J; Novitzky-Basso IN; Binnie A; Mattsson J; DSC Study Group. 2023. "Decidual stromal cells for the treatment of severe COVID-19 ARDS.". Intensive care medicine. https://doi.org/10.1007/s00134-023-07262-x
REMAP-CAP Investigators; Hills TE; Lorenzi E; Berry LR; Shyamsundar M; Al-Beidh F; Annane D; et al. 2023. "Simvastatin in Critically Ill Patients with Covid-19.". The New England journal of medicine. https://doi.org/10.1056/nejmoa2309995
Writing Committee for the REMAP-CAP Investigators; Lawler PR; Derde LPG; van de Veerdonk FL; McVerry BJ; Huang DT; Berry LR; Lorenzi E; Webb SA. 2023. "Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2023.4480
WHO Solidarity Trial Consortium. 2022. "Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.". Lancet (London, England). https://doi.org/10.1016/s0140-6736(22)00519-0
Teo K; Fowler RA; Adhikari NKJ; Rishu A; Tsang JLY; Binnie A; Murthy S; Canadian Critical Care Trials Group. 2023. "Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study.". CMAJ open. https://doi.org/10.9778/cmajo.20220129
Rajado AT; Silva N; Esteves F; Brito D; Binnie A; Araújo IM; Nóbrega C; et al. 2023. "How can we modulate aging through nutrition and physical exercise? An epigenetic approach.". Aging. https://doi.org/10.18632/aging.204668
Morgan G; Casalino S; Chowdhary S; Frangione E; Fung CYJ; Haller S; Lapadula E; et al. 2023. "Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study.". Viruses. https://doi.org/10.3390/v15081764
Morgan G; Briollais L; Clausen M; Casalino S; Mighton C; Chowdhary S; Frangione E; et al. 2023. "Public knowledge of SARS-CoV-2 serological and viral lineage laboratory testing and result interpretation: A GENCOV study cross-sectional survey.". Clinical biochemistry. https://doi.org/10.1016/j.clinbiochem.2023.110607
Sharma-Oates A; Sullivan J; Pestana D; Dos Santos CC; Binnie A; Lord JM. 2024. "Association of Epigenetic Age and Outcome in Critically Ill Patients.". Critical care explorations. https://doi.org/10.1097/cce.0000000000001044
2020. "Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.". JAMA. https://doi.org/10.1001/jama.2020.17022
COVID-19 Host Genetics Initiative. 2023. "A second update on mapping the human genetic architecture of COVID-19.". Nature. https://doi.org/10.1038/s41586-023-06355-3
Dennis BB; Thabane L; Heels-Ansdell D; Dionne JC; Binnie A; Tsang J; Guyatt G; et al. 2023. "Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial.". Trials. https://doi.org/10.1186/s13063-023-07589-2
 

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